Four possible cases of osteomalacia: The value of a multidisciplinary diagnostic approach
Publication date: Available online 11 April 2018Source: International Journal of PaleopathologyAuthor(s): A.E. van der Merwe, B. Veselka, H.A. van Veen, R.R. van Rijn, K.L. Colman, H.H. de BoerAbstractRickets and residual rickets are often encountered in Dutch archeological skeletal samples. However, no archeological Dutch paleopathological case of adult osteomalacia has been described in literature to date. This paper describes the first four archeological Dutch paleopathological cases of osteomalacia and assesses the value of the various modalities (macroscopic assessment, radiology and histology) that may be used for di...
Source: International Journal of Paleopathology - July 5, 2018 Category: Pathology Source Type: research

A probable prehistoric case of meningococcal disease from San Francisco Bay: Next generation sequencing of Neisseria meningitidis from dental calculus and osteological evidence
Publication date: Available online 25 May 2018Source: International Journal of PaleopathologyAuthor(s): Jelmer W. Eerkens, Ruth V. Nichols, Gemma G.R. Murray, Katherine Perez, Engel Murga, Phil Kaijankoski, Jeffrey S. Rosenthal, Laurel Engbring, Beth ShapiroAbstractNext Generation Sequencing (NGS) of ancient dental calculus samples from a prehistoric site in San Francisco Bay, CA-SCL-919, reveals a wide range of potentially pathogenic bacteria. One older adult woman, in particular, had high levels of Neisseria meningitidis and low levels of Haemophilus influenzae, species that were not observed in the calculus from three o...
Source: International Journal of Paleopathology - July 5, 2018 Category: Pathology Source Type: research

Unilateral absence of mandibular condyle in a Bronze Age male skeleton from Portugal
Publication date: Available online 29 May 2018Source: International Journal of PaleopathologyAuthor(s): A.M. Silva, T. Tomé, C. Cunha, J. d’Oliveira Coelho, A.C. Valera, V. Filipe, G.R. ScottAbstractIn 2009, a pit burial dated to the Bronze Age was excavated in Monte do Gato de Cima 3 (Portugal). The purpose of this paper is to describe the pathological absence of the left mandibular condyle noted in an adult male skeleton and to discuss possible diagnoses, including subcondylar fracture, cystic defect, congenital absence, condylar aplasia and mandibular condylysis. The most likely explanation for the pathological alter...
Source: International Journal of Paleopathology - July 5, 2018 Category: Pathology Source Type: research

Assessing cancer risk factors faced by an Ancestral Puebloan population in the North American Southwest
This study continues Whitley and Boyer's (2012) research testing whether concentrations of ionizing radiation were sufficiently high to induce cancer and related health issues. Access to a preserved and partly reconstructed subterranean pit structure inhabited between AD 1120 and 1170, allows us to test radon concentrations in a residential dwelling. This study found radon occurring in high levels, 19.4–20.3 pCi/L (717.8–751.1 Bq/m3) within the structure. Epidemiological reports are inconsistent when linking specific cancers and radon exposure. However, this study can control for many of the confounding factors plagu...
Source: International Journal of Paleopathology - July 5, 2018 Category: Pathology Source Type: research

Ancient cancers and infection-induced oncogenesis
Publication date: June 2018Source: International Journal of Paleopathology, Volume 21Author(s): Paul W. EwaldAbstractCancers have been reported in bone and soft tissue of ancient agricultural populations. Fossilized bones from prehistoric periods provide evidence of tumors but only one example of cancer. Difficulties in diagnosing the causes of lesions in mummified tissue and fossilized bone, and in interpreting the prevalence of cancers from remains, draw attention to the need for complementary approaches to assess the occurrence of cancer in ancient populations. This paper integrates current knowledge about pathogen indu...
Source: International Journal of Paleopathology - July 5, 2018 Category: Pathology Source Type: research