The Comparison of Exosome and Exosomal Cytokines between Young and Old Individuals with or without Gastric Cancer
Conclusion Gastric cancer and aging affect serum exosome and exosomal cytokines levels. Future studies would require the analysis of more diverse cytokines in exosomes derived from multiple types of cancer. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Ceftriaxone-Induced Non-Convulsive Status Epilepticus in an Elderly Patient with Renal Insufficiency
We present a case of ceftriaxone–induced non-convulsive status epilepticus in treatment of complicated urinary tract infection and acute on chronic kidney disease (CKD) for a 71-year-old woman. The prognosis of NCSE is poor in elderly patients due to a delay in diagnosis and treatment may be associated with increased mortality or neuronal loss, as well as dysfunction of cognitive and behavioral abilities. Emergent and continuous electroencephalogram monitoring can assist physicians in both early recognition and accurate management of NCSE. Immediate withdrawal of cephalosporin is necessary. Antiepileptic drugs may be hel...
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Qianliening Capsule Promotes Mitochondrial Pathway Mediated the Apoptosis of Benign Prostatic Hyperplasia Epithelial-1 Cells by Regulating the miRNA-181a
Conclusion QC could induce BPH-1 cells apoptosis by regulating miRNA-181a mediated mitochondrial dependent apoptosis pathway, which may be one of the important mechanisms that QC treated benign prostatic hyperplasia. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Predicting Percutaneous Nephrolithotomy Outcomes and Complications in Elderly Patients Using Guy's Scoring System and Charlson Comorbidity Index
Conclusion This study supported the use of the Charlson comorbidity index in predicting post-operative complications and the Guy's score in predicting stone-free status in elderly patients with large renal stones undergoing percutaneous nephrolithotomy. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Estimating the Calibrating Coefficient of the Framingham Score to Predict Risk of Coronary Heart Disease in the Taiwanese Population
Conclusion We generated Framingham calibration coefficient for the Taiwanese population. We recommend that the mean of predictors and the baseline survivorship derived from TwSHHH should be used in the model. Nonetheless, it is crucial to develop a risk function specific for this population. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Ulcerative Colitis in Elderly People: An Emerging Issue
Publication date: Available online 30 May 2018 Source:International Journal of Gerontology Author(s): Wei-Chen Lin, Ming-Jen Chen, Cheng-Hsin Chu, Tsang-En Wang, Horng-Yuan Wang, Chen-Wang Chang Ulcerative colitis (UC) is a common cause of chronic gastrointestinal disease in the developed world, which has a bimodal age distribution, with 10–30% of the affected population older than 60 years. Elderly patients with UC will be seen more frequently with the aging of the population and increasing incidence of UC. The management of UC in the elderly population is more complex due to comorbidities and polypharmacy. This...
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

CME questions (12.2)
Publication date: June 2018 Source:International Journal of Gerontology, Volume 12, Issue 2 (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Old Age Lower Lip Cancer Defects Reconstruction by Abbe-Estlander Flap
Publication date: June 2018 Source:International Journal of Gerontology, Volume 12, Issue 2 Author(s): Chieh-Yuan Cheng, Hsu-Wei Fang Reconstruction of lower lip defect is a challenge for oral and maxillofacial surgeons. Microvascular free flap is the main choice for lip cancer reconstruction recently but still have several morbidities presented, especially for elderly, like long surgical time and difficulty in denture fabrication. The purpose of this report is to discuss the indication and select the appropriate reconstruction technique for old age lower lip cancer patients with defects. We present 2 cases of old age ...
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Healthcare Service Utilization and Associated Factors in Community-Dwelling Elderly in Northern Taiwan: One Medical Center's Experience
Conclusions To reduce the gap in healthcare utilization between different domicile people living in urban and non-urban areas, medical treatment should be modified by different health-seeking behaviors in these areas. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Serum 25-Hydroxyvitamin D Levels: Related to Ambulatory Arterial Stiffness Index in Hypertensive Seniors
Conclusions The relationship of AASI with BMI, 24 h average SBP, 24 h average PP, Nocturnal dipping, 25(OH)D are significant. 25(OH)D (P < 0.01) and 24 h average PP (P < 0.01) were independently related to AASI. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Vitamin D Deficiency and Cardiovascular Diseases: The Causality or Association?
Publication date: June 2018 Source:International Journal of Gerontology, Volume 12, Issue 2 Author(s): Kuang-Hua Cheng (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

The Effect of Plantar Hyperkeratosis Debridement on Self-Perception of Pain Levels in older People
Conclusions The results of this study suggest that there were significant differences in self-perception of pain levels between the group of older people treated for plantar hyperkeratoses with scalpel debridement and the control group as from 24 h after treatment. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Diagnostic Difficulties and Factors Affecting Diagnosis in Acutely Ill Elderly Japanese Patients Living at Home
Conclusion Primary care providers should note subtle symptoms and the number of medications taken, provide follow-up, and consider gastrointestinal diseases when making a diagnosis following acute changes in an elderly patient. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Sonographic Measurement of Visceral Fat and Prediction of Metabolic Syndrome in the Elderly
Conclusion Measuring LKS by sonography may be a practical method for evaluating visceral fat in the elderly and for predicting MS better than sonographic fatty liver changes. LKS was more associated with abdominal girth and BMI in the elderly from the study supporting the observation that LKS are well correlated with general adiposity. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research

Polypharmacy and Willingness to Deprescribe Among Elderly with Chronic Diseases
Conclusion Majority of the elderly would like to participate in deprescribing process. Major factors that will affect patients' willingness to deprescribe were physicians' time and support as well as possible future benefits of their regular medications. (Source: International Journal of Gerontology)
Source: International Journal of Gerontology - June 28, 2018 Category: Geriatrics Source Type: research