Seroprevalence of brucellosis in Western Rajasthan: A study from a tertiary care centre
Yashik Bansal, Alisha Aggarwal, Ravisekhar Gadepalli, Vijaya Lakshmi NagIndian Journal of Medical Microbiology 2019 37(3):426-432 Brucellosis is a significant bacterial zoonotic disease with a high seroprevalence in low-to-middle-income countries where there is a significant contact of humans with animals. This prospective study was conducted to observe the seroprevalence of brucellosis in 75 symptomatic patients with pyrexia of unknown origin (PUO) and 75 high-risk individuals (10 veterinarians, 15 milkmen and 50 healthy contacts of symptomatic patients) with possible exposure to brucellosis. Serum samples collected from...
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Yashik Bansal Alisha Aggarwal Ravisekhar Gadepalli Vijaya Lakshmi Nag Source Type: research

Insights to the diphtheria toxin encoding prophages amongst clinical isolates of Corynebacterium diphtheriae from India
Dhiviya Prabaa Muthuirulandi Sethuvel, Nithya Subramanian, Agila Kumari Pragasam, Francis Yesurajan Inbanathan, Prashant Gupta, Jaichand Johnson, Naresh Chand Sharma, Nanda Hemvani, Balaji Veeraraghavan, Shalini Anandan, Lucky SangalIndian Journal of Medical Microbiology 2019 37(3):423-425 Diphtheria is a dreadful disease caused by Corynebacterium diphtheriae. Lysogenised bacteriophages carrying toxin gene in C. diphtheriae can make the strain toxigenic. However, such phage disseminates the toxin genes to other strains when it undergoes lytic phase. As little is known about the phage diversity in C. diphtheriae in India, ...
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Dhiviya Prabaa Muthuirulandi Sethuvel Nithya Subramanian Agila Kumari Pragasam Francis Yesurajan Inbanathan Prashant Gupta Jaichand Johnson Naresh Chand Sharma Nanda Hemvani Balaji Veeraraghavan Shalini Anandan Lucky Sangal Source Type: research

Diverse aminoglycoside phosphotransferase types conferring aminoglycoside resistance in Enterobacteriaceae: A single-centre study from Northeast India
This study was able to identify diverse aph types in a single centre and their corresponding phenotypic trait. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Jayalaxmi Wangkheimayum Mohana Bhattacharjee Bhaskar Jyoti Das K Melson Singha Debadatta Dhar Chanda Debadatta Dhar Chanda Deepshikha Bhowmik Amitabha Bhattacharjee Source Type: research

Occurrence of viral gastroenteritis in children below 5 years: A hospital-based study from Assam, India
Shalini Goldar, Gitika Rajbongshi, Kailash Chamuah, Syed Tanwir Alam, Ajanta SharmaIndian Journal of Medical Microbiology 2019 37(3):415-417 Viral gastroenteritis is an important cause of mortality and morbidity in children under 5 years of age. Many a time, these cases go unnoticed causing immense scarcity of data on viral diarrhoea. The study aimed to determine the occurrence of viral gastroenteritis among children below 5 years and the aetiological viral agents. Stool samples were collected from patients suffering from acute gastroenteritis. Real-time polymerase chain reaction was done for detection of rotavirus, adeno...
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Shalini Goldar Gitika Rajbongshi Kailash Chamuah Syed Tanwir Alam Ajanta Sharma Source Type: research

VP1-binding protein glucose-regulated protein 78 as an important mediator for enterovirus 71 infecting human brain microvascular endothelial cells
Conclusion: These findings provided evidence that GRP78 plays an important role during the progression of EV71 infection as a mediator in HBMEC. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Wenying Luo Peng Liang Santhosh Puthiyakunnon Lawei Yang Cao Hong Source Type: research

Dynamics of the occurrence of influenza in relation to seasonal variation in Chennai, Tamil Nadu: A 7 -year cumulative study
Conclusion: In Chennai, Tamil Nadu, influenza positivity started with the onset of monsoon and peaks during the postmonsoon months throughout the study period. The assessment of meteorological factors compounding influenza activity can help in raising alerts to the public health officials of impending disaster which suggests that Influenza vaccination can be initiated before monsoon months in South India. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Ramesh Kiruba BV Suresh Babu AK Sheriff P Gunasekaran CP Anupama N Saran V Senthil Kumar P Padmapriya N Nivas Chakravarthy Krishnasamy Kaveri Source Type: research

Emergence of dengue virus 4 as the predominant serotype during the outbreak of 2017 in South India
Conclusions: Overall this study documents the emergence of DENV4 as the major serotype in circulation, replacing DENV1, 2 and 3 which had been previously reported from Tamil Nadu and Puducherry. This substantiates the need for continuous monitoring in endemic countries like India, where such data may impact the formulation of vaccine policy for dengue. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: P Ferdinamarie Sharmila K Vanathy Barathidasan Rajamani Venkatesh Kaliaperumal Rahul Dhodapkar Source Type: research

Hepatitis B virus X protein: The X factor in chronic hepatitis B virus disease progression
Conclusion: In HBx gene, aminoacid substitutions at positions 127, 130, 131 are associated with poor expression of HBeAg. We suggest screening for HBx aminoacid substitutions especially in patients with HBeAg negative chronic HBV infection to predict the clinical outcome and enable early treatment to prevent disease progression. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Monika Mani Shanthi Vijayaraghavan Gopalsamy Sarangan Ramya Barani Priya Abraham Padma Srikanth Source Type: research

Diagnostic performance of mini parasep & #174; solvent-free foecal parasite concentrator for the diagnosis of intestinal parasitic infections
Conclusion: Mini Parasep® SF technique is simple, rapid and less cumbersome than conventional diagnostics, making it suitable for routine use. In addition, it offers higher sensitivity and better background clearance than both direct stool examination and FEM. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Abhishek Mewara Sumeeta Khurana Swati Gupta Vimal S Munda Shreya Singh Rakesh Sehgal Source Type: research

Central line-associated bloodstream infections in cancer patients: An experience from a tertiary care cancer centre
Conclusion: Over the last 20 years, an epidemiologic shift has occurred among CLABSI in cancer patients. These findings should be considered with the development of interventions that will prevent Gram-negative CLABSI after CVC insertion. To our knowledge, this is the first study reporting data on the incidence of CLABSIs in cancer patients at tertiary care hospital from North Indian hospital. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Sonu Kumari Agrawal Hitender Gautam Abdul Hakim Choudhary Bimal Kumar Das Lalit Kumar Arti Kapil Source Type: research

Frequencies of regulatory subsets of CD4 & #43; TH cells in peripheral blood in Mycobacterium Tuberculosis-Infected individuals and healthy contacts in a high-burden setting from Assam, Northeast India
Conclusion: CD4+ TH cells change dynamically to regulatory subsets depending on the status of infection and a shift of response towards excessive regulatory T-cells, and PD-1/PD-L1 production may help in the development of active infection in latently infected individuals. These immunological parameters may be used, as potential biomarkers to see the changing dynamics of Mtb infection. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Lahari Saikia Trinayan Deka Pranjal Deori Rasmi Roy Md Ezaz Hussain Reema Nath Source Type: research

Cross-country transport and isolation and identification of Streptococcus pneumoniae by use of alternate sources of blood supplemented media among laboratories in India
Conclusions: The study clearly elucidates the ability of laboratories for isolation of S. pneumoniae on human blood agar in resource limited settings. The results highlight the difficulties inherent in correctly identifying pathogens in mixed cultures in needs improvement using standardized tests across the study centers. The study also reaffirms the ability to transport biological specimens over long geographical distances without loss. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Satish Kumar Amarnath Sangeeta Joshi Madhuwanti N Abhyankar Ranjeeta Adhikary HB Beena TD Chugh KD Gandhi Vivek Hittinahalli VA Indumathi Mukhopadhyay Rajavari S Muralidharan SS Rao I Roy N Saini Source Type: research

Clonal similarities and sequence-type diversity of invasive and carriage Streptococcus pneumoniae in India among children under 5 Years
Conclusion: The vaccine serotypes were the predominant ones found to be associated with IPD, PMEN clones, new STs and antimicrobial resistance. Accordingly, PCV13 is expected to provide invasive serotype coverage of 75% in Indian children less than 5 years. This study provides baseline serotype and sequence type data prior to the introduction of PCV in South India. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Rosemol Varghese Ayyanraj Neeravi Nithya Subramanian B Pavithra A Kavipriya Jones Lionel Kumar CP Girish Kumar Yuvraj Jeyraman G Karthik Valsan P Verghese Balaji Veeraraghavan Source Type: research

Seroprevalence of Toxoplasmosis at a Tertiary Care Centre in North India from 2004 to 2014
Conclusion: Toxoplasma infection is highly prevalent in the population of North India across various clinical categories of patients. Future studies focusing on continuous monitoring of seroprevalence trends and elucidation of the risk factors associated with seropositivity in more defined groups of patients are needed. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Abhishek Mewara Shreya Singh Sumeeta Khurana Parakriti Gupta Rakesh Sehgal Source Type: research

Detection and molecular typing of campylobacter isolates from human and animal faeces in coastal belt of Odisha, India
Conclusion: The present study showed the incidence of Campylobacter infections in human and different animal species in and around Bhubaneswar, Odisha. The analysis suggested that domestic animals can be the potential sources for human campylobacteriosis in the region. (Source: Indian Journal of Medical Microbiology)
Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Nirmal Kumar Mohakud Saumya Darshana Patra Subrat Kumar Priyadarshi Soumyaranjan Sahu Namrata Misra Arpit Kumar Shrivastava Source Type: research