Frequencies of regulatory subsets of CD4 & #43; TH cells in peripheral blood in Mycobacterium Tuberculosis-Infected individuals and healthy contacts in a high-burden setting from Assam, Northeast India

Conclusion: CD4+ TH cells change dynamically to regulatory subsets depending on the status of infection and a shift of response towards excessive regulatory T-cells, and PD-1/PD-L1 production may help in the development of active infection in latently infected individuals. These immunological parameters may be used, as potential biomarkers to see the changing dynamics of Mtb infection.

Source: Indian Journal of Medical Microbiology - January 28, 2020 Category: Microbiology Authors: Lahari Saikia Trinayan Deka Pranjal Deori Rasmi Roy Md Ezaz Hussain Reema Nath Source Type: research