Effects of GGsTop(R) on Collagen and Glutathione in the Oral Mucosa Using a Rat Model of 5-Fluorouracil-Induced Oral Mucositis
Conclusion: GGsTop affects collagen and glutathione in the treatment of oral mucositis. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: TAKEUCHI, I., KAWAMATA, R., MAKINO, K. Tags: Experimental Studies Source Type: research
Correlation Between Onco-suppressors PTEN and NM23 and Clinical Outcome in Patients With T1 Breast Cancer
Conclusion: Low or lack of PTEN and NM23 immunohistochemical expression in cancer tissue is a risk factor for lymph node involvement and recurrent disease. It may represent a valid prognostic factor in planning therapy in patients who had surgery for T1 breast cancer. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: IZZO, L., MESSINEO, D., DI CELLO, P., NICOLANTI, V., STERPETTI, A., IZZO, S., IZZO, P. Tags: Experimental Studies Source Type: research
NR6A1 Allelic Frequencies as an Index for both Miniaturizing and Increasing Pig Body Size
Conclusion: NR6A1 could be a useful index for both miniaturizing and increasing pig body size. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: IJIRI, M., LAI, Y.-C., KAWAGUCHI, H., FUJIMOTO, Y., MIURA, N., MATSUO, T., TANIMOTO, A. Tags: Experimental Studies Source Type: research
Protective Effects of Baicalin on Arsenic Trioxide-induced Oxidative Damage and Apoptosis in Human Umbilical Vein Endothelial Cells
Conclusion: Baicalin was found to have the potential capacity to protect endothelial cells from As2O3-induced cytotoxicity. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: TSAI, C.-L., TSAI, C.-W., CHANG, W.-S., LIN, J.-C., HSIA, T.-C., BAU, D.-T. Tags: Experimental Studies Source Type: research
PolyIC Induces Retinoic Acid-inducible Gene-I and Melanoma Differentiation-associated Gene 5 and Modulates Inflammation in Podocytes
Conclusion: RIG-I and MDA5 may play a role in the antiviral responses of podocytes. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: NAKATA, M., SHIMADA, M., NARITA-KINJO, I., NAGAWA, D., KITAYAMA, K., HAMADATE, M., MIURA, N., NOZAKA, M., KAWAMURA, Y., FUJITA, T., MURAKAMI, R., IMAIZUMI, T., NAKAMURA, N., TOMITA, H. Tags: Experimental Studies Source Type: research
Combining Nelfinavir With Chloroquine Inhibits In Vivo Growth of Human Lung Cancer Xenograft Tumors
Conclusion: Our findings suggest that the induction of proteotoxicity provides a promising new target for developing anticancer drugs. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: LOPICCOLO, J., KAWABATA, S., GILLS, J. J., DENNIS, P. A. Tags: Experimental Studies Source Type: research
Low DUSP4 Expression Is Associated With Aggressive Phenotypes and Poor Prognosis in Gastric Cancer
Conclusion: Low expression of DUSP4 is associated with aggressive phenotypes of gastric cancer and a poor prognosis. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: BANG, S., JEE, S., KIM, H., JANG, K., PARK, H., MYUNG, J. K., CHOI, D., SHIN, S.-J., PAIK, S. S. Tags: Experimental Studies Source Type: research
Inhibition of Colony-Stimulating Factor-1 Receptor Enhances the Efficacy of Radiotherapy and Reduces Immune Suppression in Glioblastoma
Conclusion: Inhibition of CSF-1R improved response to RT in the treatment of GBM and may represent a promising strategy to improve RT-induced antitumor immune responses. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: ALMAHARIQ, M. F., QUINN, T. J., KESARWANI, P., KANT, S., MILLER, C. R., CHINNAIYAN, P. Tags: Experimental Studies Source Type: research
In Vivo Evaluation of Combined CK2 Inhibition and Irradiation in Human WiDr Tumours
Conclusion: The absence of radiosensitization by CK2 inhibition should be investigated in different tumour models. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: ZWICKER, F., HAUSWALD, H., WEBER, K.-J., DEBUS, J., HUBER, P. E. Tags: Experimental Studies Source Type: research
A Novel Procedure for Orthotopic Tibia Implantation for Establishment of a More Clinical Osteosarcoma PDOX Mouse Model
Conclusion: The establishment ratio for this procedure is 80% making it a practical and clinically-relevant model for screening effective therapies for osteosarcoma patients. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: WU, N. F., YAMAMOTO, J., BOUVET, M., HOFFMAN, R. M. Tags: Experimental Studies Source Type: research
The Angiotensin-converting Enzyme Insertion/Deletion Polymorphism as a Common Risk Factor for Major Pregnancy Complications
Idiopathic pregnancy complications pose a major threat to both maternal and fetal health worldwide. Numerous studies have implicated the role of the renin-angiotensin system (RAS) in the development of obstetric syndromes, since it is crucial for the uteroplacental function. A major RAS component is the angiotensin-converting enzyme (ACE), which hydrolyses angiotensin I to angiotensin II, and not only regulates arterial pressure, but also fibrinolytic activity, indirectly, through the expression of plasminogen activator inhibitor-1. A key functional polymorphism of the ACE gene is the insertion/deletion (I/D) polymorphism,...
Source: In Vivo - January 5, 2021 Category: Research Authors: GINTONI, I., ADAMOPOULOU, M., YAPIJAKIS, C. Tags: Reviews Source Type: research
Inflammatory Fibroid Polyp of the Gastrointestinal Tract: A Systematic Review for a Benign Tumor
Conclusion: It is relatively safe to conclude that both the etiology and the timing of diagnosis might change the histopathology, immunohistological staining and tissue structure of IFP. Suggested theories should be taken into consideration with caution as the etiology and pathophysiological mechanisms of IFP are unknown. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: GARMPIS, N., DAMASKOS, C., GARMPI, A., GEORGAKOPOULOU, V. E., SAKELLARIOU, S., LIAKEA, A., SCHIZAS, D., DIAMANTIS, E., FARMAKI, P., VOUTYRITSA, E., SYLLAIOS, A., PATSOURAS, A., SYPSA, G., AGOROGIANNI, A., STELIANIDI, A., ANTONIOU, E. A., KONTZOGLOU, K., T Tags: Reviews Source Type: research
Contemporary Molecular Classification of Urinary Bladder Cancer
The significant heterogeneity in the clinical outcome among patients with bladder cancer has highlighted the existence of different biological subtypes of muscle-invasive and non-muscle-invasive bladder cancer. Transcriptional profiling studies revealed that primary bladder cancers can be grouped into ‘intrinsic’ basal and luminal molecular subtypes. Luminal tumors have a papillary configuration and express markers of urothelial differentiation (uroplakins, cytokeratin 20) fibroblast growth factor 3 (FGFR3), E-cadherin and early cell-cycle genes. On the contrary, basal tumors express markers of the basal layer ...
Source: In Vivo - January 5, 2021 Category: Research Authors: GOUTAS, D., TZORTZIS, A., GAKIOPOULOU, H., VLACHODIMITROPOULOS, D., GIANNOPOULOU, I., LAZARIS, A. C. Tags: Reviews Source Type: research
An Update on Clinicopathological, Imaging and Genetic Features of Desmoplastic Fibroblastoma (Collagenous Fibroma)
Desmoplastic fibroblastoma (also known as collagenous fibroma) is an uncommon benign fibroblastic/myofibroblastic neoplasm that primarily arises in the subcutaneous tissue of upper extremity. Magnetic resonance imaging reveals a well-defined mass in intimate association with dense connective tissue and prominent low signal intensity on all pulse sequences. Peripheral and septal enhancement is usually seen after intravenous contrast. Histologically, the lesion is paucicellular and consists of spindle to stellate-shaped cells embedded in a collagenous or myxocollagenous stroma with low vascularity. Diffuse and strong nuclear...
Source: In Vivo - January 5, 2021 Category: Research Authors: NAKAYAMA, S., NISHIO, J., AOKI, M., NABESHIMA, K., YAMAMOTO, T. Tags: Reviews Source Type: research
PCSK9 Antibody-based Treatment Strategies for Patients With Statin Intolerance
Conclusion: PCSK9 inhibition can be considered as a treatment of option for lipid-lowering in statin-intolerant patients. (Source: In Vivo)
Source: In Vivo - January 5, 2021 Category: Research Authors: VOUTYRITSA, E., DAMASKOS, C., FARMAKI, P., KYRIAKOS, G., DIAMANTIS, E., QUILES-SANCHEZ, L. V., GARMPI, A., GARMPIS, N., PATSOURAS, A., STELIANIDI, A., SAVVANIS, S. Tags: Reviews Source Type: research
