Therapeutic Efficacy and Inhibitory Mechanism of Regorafenib Combined With Radiation in Colorectal Cancer
Conclusion: Regorafenib may enhance the anti-CRC efficacy of RT. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: LIU, Y.-C., CHIANG, I.-T., CHUNG, J.-G., HSIEH, J.-H., CHIANG, C.-H., WENG, M.-C., HSU, F.-T., LEE, Y.-H., CHANG, C.-S., LIN, S.-S. Tags: Experimental Studies Source Type: research
Continuity of Tumor Microenvironmental Suppression in AOM/DSS Mice by Fucoxanthin May Be Able to Track With Salivary Glycine
Conclusion: Salivary glycine is a valuable indicator that could evaluate sustained efficacy of cancer chemopreventive effects of Fx in AOM/DSS mice. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: TERASAKI, M., KIMURA, R., KUBOTA, A., KOJIMA, H., TANAKA, T., MAEDA, H., MIYASHITA, K., MUTOH, M. Tags: Experimental Studies Source Type: research
The Effect of Gemcitabine on Cell Cycle Arrest and microRNA Signatures in Pancreatic Cancer Cells
Conclusion: Altered miRNAs may serve as potential therapeutic targets for improving the efficacy of gemcitabine in PDAC. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: NAMIMA, D., FUJIHARA, S., IWAMA, H., FUJITA, K., MATSUI, T., NAKAHARA, M., OKAMURA, M., HIRATA, M., KONO, T., FUJITA, N., YAMANA, H., KATO, K., KAMADA, H., MORISHITA, A., KOBARA, H., TSUTSUI, K., MASAKI, T. Tags: Experimental Studies Source Type: research
A Novel Lipofuscin-detecting Marker of Senescence Relates With Hypoxia, Dysregulated Autophagy and With Poor Prognosis in Non-small-cell-lung Cancer
Conclusion: SenTraGor™ provides a reliable methodology to detect lipofuscin accumulation in cancer cells in paraffin-embedded tissues, opening a new field for translational studies focused on senescence. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: GIATROMANOLAKI, A., KOUROUPI, M., BALASKA, K., KOUKOURAKIS, M. I. Tags: Experimental Studies Source Type: research
Significant Association of MMP2 Promoter Genotypes to Asthma Susceptibility in Taiwan
Conclusion: The genotype of CT in MMP2 rs243845 may serve as a novel biomarker in determining susceptibility to asthma in Taiwan. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: CHEN, L.-H., CHIU, K.-L., HSIA, T.-C., LEE, Y.-H., SHEN, T.-C., LI, C.-H., SHEN, Y.-C., CHANG, W.-S., TSAI, C.-W., BAU, D.-T. Tags: Experimental Studies Source Type: research
Clinical Significance of Tumor and Immune Cell PD-L1 Expression in Gastric Adenocarcinoma
Conclusion: PD-L1 protein expression in TCs and ICs can be used as a prognostic indicator for GC patients, particularly in the EBV–, MSI, and MSS subgroups. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: KIM, D. H., BAE, G. E., SUH, K. S., RYUMAN, D., SONG, K. S., KIM, J. S., LEE, S.-I., YEO, M.-K. Tags: Experimental Studies Source Type: research
Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model
Conclusion: The TNBC liver metastasis was highly aggressive resulting in re-metastasis and ascites. o-rMETase tended to inhibit the liver metastasis and significantly improved the mouse body-condition score. This new PDOX model of TNBC liver metastasis will be useful for identifying effective agents for this recalcitrant disease. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: LIM, H. I., YAMAMOTO, J., HAN, Q., SUN, Y., NISHINO, H., TASHIRO, Y., SUGISAWA, N., TAN, Y., CHOI, H. J., NAM, S. J., BOUVET, M., HOFFMAN, R. M. Tags: Experimental Studies Source Type: research
Ligation Method to Specifically Label a Liver Segment With Indocyanine Green in an Orthotopic Nude-Mouse Liver-Metastasis Model
Conclusion: The ligation of the Glissonean pedicle enables specific liver-segment labeling with ICG, which has potential clinical application for liver metastasectomy. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: NISHINO, H., HOLLANDSWORTH, H. M., TASHIRO, Y., YAMAMOTO, J., AMIRFAKHRI, S., FILEMONI, F., SUGISAWA, N., HOFFMAN, R. M., BOUVET, M. Tags: Experimental Studies Source Type: research
Sutureless Surgical Orthotopic Implantation Technique of Primary and Metastatic Cancer in the Liver of Mouse Models
Conclusion: This novel method for establishing orthotopic liver-implantation mouse models is suitable for studies of liver cancer and liver metastases due to its simple procedure and potential high engraftment rate. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: NISHINO, H., HOLLANDSWORTH, H. M., SUGISAWA, N., YAMAMOTO, J., TASHIRO, Y., INUBUSHI, S., HAMADA, K., SUN, Y., LIM, H., AMIRFAKHRI, S., FILEMONI, F., HOFFMAN, R. M., BOUVET, M. Tags: Experimental Studies Source Type: research
Specialized Histological and Histomorphometrical Analytical Methods for Biocompatibility Testing of Biomaterials for Maxillofacial Surgery in (Pre-) Clinical Studies
We present a short overview of the most important steps of the different workup and analytical methods used in preclinical and clinical biopsies for both novice and experienced researchers in the field of biomaterial science. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: LINDNER, C., PROHL, A., ABELS, M., LOFFLER, T., BATINIC, M., JUNG, O., BARBECK, M. Tags: Reviews Source Type: research
Thyroid Dysfunction and Atherosclerosis: A Systematic Review
Conclusion: Most studies have concluded that thyroid dysfunction is associated with arterial wall remodeling and, thus, with increased cardiovascular risk. However, the exact mechanistic background of pathological structural changes in the arterial wall is still unsettled. Large randomized controlled studies are required to definitively address the extent to which T4 replacement therapy might benefit patients with subclinical thyroid disorders. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: PAPADOPOULOU, A.-M., BAKOGIANNIS, N., SKRAPARI, I., MORIS, D., BAKOYIANNIS, C. Tags: Reviews Source Type: research
Systemic Review and Meta-analysis of Impact of Splenectomy for Advanced Gastric Cancer
Background/Aim: Prophylactic splenectomy has shown no inferiority for tumors not invading the greater curvature side. Despite this, the clinical impact of prophylactic splenectomy for proximal advanced gastric cancer is not clear. This review aimed to clarify the impact of splenectomy for advanced gastric cancer in the upper third of the stomach. Materials and Methods: A systematic review and meta-analysis were conducted based on PubMed and EMBASE databases. The following search terms were used: "gastric cancer" OR "splenectomy" OR upper third of the stomach" OR preservation of the spleen. Results: Out of 765 articles, 18 ...
Source: In Vivo - November 3, 2020 Category: Research Authors: KUNISAKI, C., SATO, S., TSUCHIYA, N., WATANABE, J., SATO, T., TAKEDA, K., KASAHARA, K., KOSAKA, T., AKIYAMA, H., ENDO, I., MISUMI, T. Tags: Reviews Source Type: research
Lipid-lowering Drugs and Neurocognitive Function: A Systematic Review
Conclusion: Lipid-lowering drugs seem to have no significant effect on neurocognitive function, but further research specifically focused on this matter is needed. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: KYRIAKOS, G., QUILES-SANCHEZ, L. V., DIAMANTIS, E., FARMAKI, P., GARMPIS, N., DAMASKOS, C., SAVVANIS, S., PATSOURAS, A., STELIANIDI, A., VOUTYRITSA, E., GEORGAKOPOULOU, V. E., GARMPI, A. Tags: Reviews Source Type: research
Review of Innovative Physical Therapy Methods: Introduction to the Principles of Cold Physical Plasma
The principles of physics and precision engineering have allowed many technologies to enter standard treatment regimens for a range of diseases. Recently, a new type of technology has been accredited as safe and efficient routine procedure in dermatology in Europe: cold physical plasma. Several accredited devices successfully restrain the powerful energy of plasmas to make them available for therapeutic purposes. Herein, we introduce an introduction to the concept of cold physical plasmas and highlight some fields of their medical applications. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: KLETSCHKUS, K., HARALAMBIEV, L., MUSTEA, A., BEKESCHUS, S., STOPE, M. B. Tags: Reviews Source Type: research
Telomere Length and Hematological Disorders: A Review
In conclusion, the experimental and clinical data analyzed in this review demonstrate that excessive telomere shortening is present in major hematological malignancies and its analysis and measurement is a crucial step in determining patient prognosis, predicting disease risk and assisting in the decision for targeted therapeutic strategies. (Source: In Vivo)
Source: In Vivo - November 3, 2020 Category: Research Authors: NOGUEIRA, B. M. D., MACHADO, C. B., MONTENEGRO, R. C., DE MORAES, M. E. A., MOREIRA-NUNES, C. A. Tags: Reviews Source Type: research
