Response of Triple-negative Breast Cancer Liver Metastasis to Oral Recombinant Methioninase in a Patient-derived Orthotopic Xenograft (PDOX) Model

Conclusion: The TNBC liver metastasis was highly aggressive resulting in re-metastasis and ascites. o-rMETase tended to inhibit the liver metastasis and significantly improved the mouse body-condition score. This new PDOX model of TNBC liver metastasis will be useful for identifying effective agents for this recalcitrant disease.

Source: In Vivo - November 3, 2020 Category: Research Authors: LIM, H. I., YAMAMOTO, J., HAN, Q., SUN, Y., NISHINO, H., TASHIRO, Y., SUGISAWA, N., TAN, Y., CHOI, H. J., NAM, S. J., BOUVET, M., HOFFMAN, R. M. Tags: Experimental Studies Source Type: research