Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - June 13, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research
Hypertension Editors&x2019; Picks [Editors’ Picks]
(Source: Hypertension)
Source: Hypertension - June 13, 2018 Category: Cardiology Authors: The Editors Tags: Editors ’ Picks Source Type: research
Editorial Board [Editorial Board]
(Source: Hypertension)
Source: Hypertension - June 13, 2018 Category: Cardiology Tags: Editorial Board Source Type: research
2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines [Clinical Practice Guideline: Executive Summary]
(Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Paul K. Whelton, Robert M. Carey, Wilbert S. Aronow, Donald E. Casey, Jr, Karen J. Collins, Cheryl Dennison Himmelfarb, Sondra M. DePalma, Samuel Gidding, Kenneth A. Jamerson, Daniel W. Jones, Eric J. MacLaughlin, Paul Muntner, Bruce Ovbiagele, Sidney C. Tags: Statements and Guidelines Clinical Practice Guideline: Executive Summary Source Type: research
Persistent Organochlorine Pollutants in Plasma, Blood Pressure, and Hypertension in a Longitudinal StudyNovelty and Significance [Organochlorine Pollutants and Hypertension]
Persistent organochlorine pollutants (POPs) have shown to be involved in the atherosclerotic process and to cause endothelial cell dysfunction. To assess longitudinally whether plasma concentrations of different POPs were associated with blood pressure and risk of hypertension in middle-aged women and men. Study subjects were 850 participants in the VIP (Västerbotten Intervention Programme) with 2 blood samples and blood pressure measurements, 10 years apart, during 1990 to 2003 (baseline) and during 2000 to 2013 (follow-up). Dioxin-like and nondioxin-like polychlorinated biphenyls (DL-PCBs, NDL-PCBs) and p,p′-dichlorod...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Carolina Donat–Vargas, Agneta Akesson, Andreas Tornevi, Maria Wennberg, Johan Sommar, Hannu Kiviranta, Panu Rantakokko, Ingvar A. Bergdahl Tags: Epidemiology, Primary Prevention, Risk Factors, High Blood Pressure, Hypertension Original Articles Source Type: research
Neuronal Suppressor of Cytokine Signaling 3Novelty and Significance [Leptin]
We determined whether deficiency of neuronal SOCS3 (suppressor of cytokine signaling 3)—a potential negative regulator of leptin signaling—amplifies the chronic effects of leptin on food intake, energy expenditure, glucose, and blood pressure (BP) and protects against adverse cardiometabolic effects of obesity. BP and heart rate were recorded by telemetry, and oxygen consumption (VO2) was monitored in 22-week-old mice with nervous system SOCS3 deficiency (SOCS3-Nestin-Cre) and control mice (SOCS3flox/flox) fed normal or high-fat–high-fructose diet from 6 to 22 weeks of age. Compared with controls, SOCS3-Nestin-Cre mi...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Jussara M. do Carmo, Alexandre A. da Silva, John Nathan Freeman, Zhen Wang, Sydney P. Moak, Michael W. Hankins, Heather A. Drummond, John E. Hall Tags: Hypertension Original Articles Source Type: research
Discovery of New Blood Pressure Phenotypes and Relation to Accuracy of Cuff Devices Used in Daily Clinical PracticeNovelty and Significance [Blood Pressure Phenotypes]
Cuff blood pressure (BP) is the reference standard for management of high BP, but the method is inaccurate and can lead to BP misclassification. The aims of this study were to determine whether distinctive BP phenotypes exist based on BP transmission (amplification) variability from central-to-peripheral arteries and whether applying one standard cuff BP measurement approach (eg, oscillometry) to all people could discriminate the BP phenotypes. Intra-arterial BP was measured at the ascending aorta and brachial and radial arteries in 126 participants (61±10 years; 69% male) after coronary angiography. Central-to-peripheral...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Dean S. Picone, Martin G. Schultz, Xiaoqing Peng, J. Andrew Black, Nathan Dwyer, Philip Roberts-Thomson, Chen-Huan Chen, Hao-Min Cheng, Giacomo Pucci, Ji-Guang Wang, James E. Sharman Tags: Physiology, High Blood Pressure, Blood Pressure Original Articles Source Type: research
Neurotransmitter Switching Coupled to {beta}-Adrenergic Signaling in Sympathetic Neurons in Prehypertensive StatesNovelty and Significance [Nervous System]
Single or combinatorial administration of β-blockers is a mainstay treatment strategy for conditions caused by sympathetic overactivity. Conventional wisdom suggests that the main beneficial effect of β-blockers includes resensitization and restoration of β1-adrenergic signaling pathways in the myocardium, improvements in cardiomyocyte contractility, and reversal of ventricular sensitization. However, emerging evidence indicates that another beneficial effect of β-blockers in disease may reside in sympathetic neurons. We investigated whether β-adrenoceptors are present on postganglionic sympathetic neurons and facilit...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Emma N. Bardsley, Harvey Davis, Keith J. Buckler, David J. Paterson Tags: Animal Models of Human Disease, Autonomic Nervous System, Cell Signaling/Signal Transduction, Cardiovascular Disease, Hypertension Original Articles Source Type: research
Vascular Function Is Improved After an Environmental Enrichment ProgramNovelty and Significance [Cognitive and Vascular Function]
In conclusion, a multidomain training program slows cognitive decline, especially in hypertensive individuals. This effect is accompanied by improved systemic endothelial function, mobilization of progenitor CD34+ cells, and preserved carotid distensibility.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01725178. (Source: Hypertension)
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Rosa Maria Bruno, Francesco Stea, Rosa Sicari, Lorenzo Ghiadoni, Stefano Taddei, Andrea Ungar, Ubaldo Bonuccelli, Gloria Tognoni, Simona Cintoli, Serena Del Turco, Silverio Sbrana, Luna Gargani, Gennaro D’Angelo, Lorenza Pratali, Nicoletta Berardi, Tags: Endothelium/Vascular Type/Nitric Oxide, Exercise, Ultrasound Original Articles Source Type: research
Cystathionine {gamma}-Lyase-Produced Hydrogen Sulfide Controls Endothelial NO Bioavailability and Blood PressureNovelty and Significance [Oxidative Stress]
Hydrogen sulfide (H2S) and NO are important gasotransmitters, but how endogenous H2S affects the circulatory system has remained incompletely understood. Here, we show that CTH or CSE (cystathionine γ-lyase)-produced H2S scavenges vascular NO and controls its endogenous levels in peripheral arteries, which contribute to blood pressure regulation. Furthermore, eNOS (endothelial NO synthase) and phospho-eNOS protein levels were unaffected, but levels of nitroxyl were low in CTH-deficient arteries, demonstrating reduced direct chemical interaction between H2S and NO. Pretreatment of arterial rings from CTH-deficient mice wit...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Istvan Andras Sziȷarto, Laȷos Marko, Milos R. Filipovic, Jan Lȷ Milȷkovic, Christoph Tabeling, Dmitry Tsvetkov, Ning Wang, Luiza A. Rabelo, Martin Witzenrath, Andre Diedrich, Jens Tank, Noriyuki Akahoshi, Shotaro Kamata, Isao I Tags: Endothelium/Vascular Type/Nitric Oxide, Mechanisms, Vascular Biology, Hypertension Original Articles Source Type: research
Vascular Cell Glycocalyx-Mediated Vascular Remodeling Induced by Hemodynamic Environmental AlterationNovelty and Significance [Vascular Remodeling]
Vascular remodeling induced by hemodynamic stimuli contributes to the pathophysiology of cardiovascular diseases. The importance of vascular cells (endothelial cells and smooth muscle cells) glycocalyx in the mechanotransduction of flow-induced shear stress at the cellular and molecular levels has been demonstrated over the past decade. However, its potential mechanotransduction role in vascular remodeling has triggered little attention. In the present study, a home-made apparatus was used to expose the rat abdominal aorta to sterile, flow or no flow, normal-pressure or high-pressure conditions for 4 days. The histomophome...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Jiajia Liu, Hongyan Kang, Xuejiao Ma, Anqiang Sun, Huiqin Luan, Xiaoyan Deng, Yubo Fan Tags: Basic Science Research, Vascular Biology, Remodeling, High Blood Pressure, Hypertension Original Articles Source Type: research
Age- and Sex-Specific Reference Values for Media/Lumen Ratio in Small Arteries and Relationship With Risk FactorsNovelty and Significance [Vascular Remodeling]
Small-artery remodeling is an early feature of target organ damage in hypertension and retains a negative prognostic value. The aim of the study is to establish age- and sex-specific reference values for media/lumen in small arteries obtained in humans by biopsy. Data from 91 healthy individuals and 200 individuals with cardiovascular risk factors in primary prevention from 4 Italian centers were pooled. Sex-specific equations for media/lumen in the healthy subpopulation, with age as dependent variable, were calculated. These equations were used to calculate predicted media/lumen values in individuals with risk factors and...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Rosa Maria Bruno, Guido Grassi, Gino Seravalle, Carmine Savoia, Damiano Rizzoni, Agostino Virdis Tags: Pathophysiology Original Articles Source Type: research
Serum and Urine Thioflavin-T-Enhanced Fluorescence in Severe PreeclampsiaNovelty and Significance [Preeclampsia]
Common features of amyloid-like proteotoxic aggregates are the ability to bind Congo red (congophilia) and to induce fluorescence of thioflavin-T (ThT). Based on the prior discovery that women with preeclampsia exhibit urine congophilia, we proposed that amyloid-like protein aggregates present in urine also circulate in the bloodstream and this feature is linked to disease severity and clinical phenotype. ThT fluorescence was investigated in 217 paired serum and urine samples from women with severe features of preeclampsia (n=101; median [interquartile range] gestational age [GA], 32 [29–35] weeks), mild features of pree...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Katherine R. Millen, Catalin S. Buhimschi, Guomao Zhao, Kara M. Rood, Sammy Tabbah, Irina A. Buhimschi Tags: Pathophysiology, Hypertension, Preeclampsia Original Articles Source Type: research
Neurofilament as Neuronal Injury Blood Marker in Preeclampsia [Preeclampsia]
Preeclampsia has been shown to be associated with changes in cerebral structure and cognitive function later in life. Nf (neurofilaments) are specific scaffolding proteins of neurons, and their quantification in serum has been proposed as a biomarker for neuroaxonal injury. We performed a prospective, longitudinal, single-center study at the University Hospital of Basel to determine serum Nf concentrations in pregnant women with singleton pregnancies and with high risk of preeclampsia or with early signs of preeclampsia. Enrollment started at 21 weeks of gestation, followed up with multiple visits until delivery. Sixty out...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Katrina Suzanne Evers, Andrew Atkinson, Christian Barro, Urs Fisch, Marc Pfister, Evelyn A. Huhn, Olav Lapaire, Jens Kuhle, Sven Wellmann Tags: Hypertension, Preeclampsia Original Articles Source Type: research
Influence of Gestational Age at Initiation of Antihypertensive TherapyNovelty and Significance [Pregnancy and Hypertension]
For hypertensive women in CHIPS (Control of Hypertension in Pregnancy Study), we assessed whether the maternal benefits of tight control could be achieved, while minimizing any potentially negative effect on fetal growth, by delaying initiation of antihypertensive therapy until later in pregnancy. For the 981 women with nonsevere, chronic or gestational hypertension randomized to less-tight (target diastolic blood pressure, 100 mm Hg), or tight (target, 85 mm Hg) control, we used mixed-effects logistic regression to examine whether the effect of less-tight (versus tight) control on major outcomes was dependent on gestation...
Source: Hypertension - May 9, 2018 Category: Cardiology Authors: Anouk Pels, Ben Willem J. Mol, Joel Singer, Terry Lee, Peter von Dadelszen, Wessel Ganzevoort, Elizabeth Asztalos, Laura A. Magee, on behalf of the CHIPS Study Group* Tags: Hypertension, Preeclampsia Original Articles Source Type: research
