Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in MiceNovelty and Significance [Preeclampsia]
We examined the pregnancy effects in mice with a modified Edn1 allele that increases mRNA stability and thus ET-1 production. Heterozygous Edn1H/+ females showed no obvious abnormalities before pregnancy, but when mated with wild-type (WT) males developed a full spectrum of preeclampsia-like phenotypes, including increased systolic blood pressure, proteinuria, glomerular endotheliosis, and intrauterine fetal growth restriction. At 7.5 days post-coitus, the embryos from Edn1H/+ dams, regardless of their Edn1 genotype, lagged 12 hours in development compared with embryos from WT dams, had disoriented ectoplacental cones, and...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Feng Li, Masao Kakoki, Marcela Smid, Kim Boggess, Jennifer Wilder, Sylvia Hiller, Carol Bounajim, Scott E. Parnell, Kathleen K. Sulik, Oliver Smithies, Nobuyo Maeda-Smithies Tags: Preeclampsia Original Articles Source Type: research
AT1-AA (Angiotensin II Type 1 Receptor Agonistic Autoantibody) Blockade Prevents Preeclamptic Symptoms in Placental Ischemic RatsNovelty and Significance [Preeclampsia]
In this study, we examined the maternal outcomes of AT1-AA inhibition (‵n7AAc′) in RUPP rats. Blood pressure was higher in RUPP rats versus normal pregnant (NP) rats (123±2 versus 99±2 mm Hg, P (Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Mark W. Cunningham, Jr, Javier Castillo, Tarek Ibrahim, Denise C. Cornelius, Nathan Campbell, Lorena Amaral, Venkata Ramana Vaka, Nathan Usry, Jan M. Williams, Babbette LaMarca Tags: Animal Models of Human Disease Original Articles Source Type: research
Secreted Klotho Attenuates Inflammation-Associated Aortic Valve Fibrosis in Senescence-Accelerated Mice P1Novelty and Significance [Heart]
Senescence-accelerated mice P1 (SAMP1) is an aging model characterized by shortened lifespan and early signs of senescence. Klotho is an aging-suppressor gene. The purpose of this study is to investigate whether in vivo expression of secreted klotho (Skl) gene attenuates aortic valve fibrosis in SAMP1 mice. SAMP1 mice and age-matched (AKR/J) control mice were used. SAMP1 mice developed obvious fibrosis in aortic valves, namely fibrotic aortic valve disease. Serum level of Skl was decreased drastically in SAMP1 mice. Expression of MCP-1 (monocyte chemoattractant protein 1), ICAM-1 (intercellular adhesion molecule 1), F4/80,...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Jianglei Chen, Jun Fan, Shirley Wang, Zhongjie Sun Tags: Basic Science Research Original Articles Source Type: research
Novel Role for the Immunoproteasome Subunit PSMB10 in Angiotensin II-Induced Atrial Fibrillation in MiceNovelty and Significance [Heart]
Angiotensin II (Ang II) and inflammation are associated with pathogenesis of atrial fibrillation (AF), but the underlying molecular mechanisms of these events remain unknown. The immunoproteasome has emerged as a critical regulator of inflammatory responses. Here, we investigated its role in Ang II–induced AF in immunosubunit PSMB10 (also known as β2i or LMP10) knockout (KO) mice. AF was induced by Ang II infusion (2000 ng/min per kg). PSMB10 expression and trypsin-like activity were increased in atrial tissues and serum from Ang II–treated mice or serum from patients with AF. Moreover, Ang II–infused wild-type (WT)...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Jing Li, Shuai Wang, Jie Bai, Xiao-Lei Yang, Yun-Long Zhang, Yi-Lin Che, Hui-Hua Li, Yan-Zong Yang Tags: Atrial Fibrillation, ACE/Angiotensin Receptors/Renin Angiotensin System, Animal Models of Human Disease Original Articles Source Type: research
Relationship of Sodium Intake and Blood Pressure Varies With Energy IntakeNovelty and Significance [DASH-Sodium Trial]
Dietary Na recommendations are expressed as absolute amounts (mg/d) rather than as Na density (mg/kcal). Our objective was to determine whether the strength of the relationship of Na intake with blood pressure (BP) varied with energy intake. The DASH (Dietary Approaches to Stop Hypertension)–Sodium trial was a randomized feeding trial comparing 2 diets (DASH and control) and 3 levels of Na density. Participants with pre- or stage 1 hypertension consumed diets for 30 days in random order; energy intake was controlled to maintain body weight. This secondary analysis of 379 non-Hispanic black and white participants used mix...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Maureen A. Murtaugh, Jeannette M. Beasley, Lawrence J. Appel, Patricia M. Guenther, Molly McFadden, Tom Greene, Janet A. Tooze Tags: Diet and Nutrition, High Blood Pressure, Hypertension Original Articles Source Type: research
Blood Pressure Measurement in SPRINT (Systolic Blood Pressure Intervention Trial)Novelty and Significance [SPRINT Trial]
Recent publications have stated that the blood pressure (BP) measurement technique used in SPRINT (Systolic Blood Pressure Intervention Trial) was unattended. However, the SPRINT protocol does not address the issue of attendance. A survey was conducted immediately after SPRINT closeout visits were completed to inquire whether BP measurements were usually attended or unattended by staff. There were 4082 participants at 38 sites that measured BP after leaving the participant alone the entire time (always alone), 2247 at 25 sites that had personnel in the room the entire time (never alone), 1746 at 19 sites that left the part...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Karen C. Johnson, Paul K. Whelton, William C. Cushman, Jeffrey A. Cutler, Gregory W. Evans, Joni K. Snyder, Walter T. Ambrosius, Srinivasan Beddhu, Alfred K. Cheung, Lawrence J. Fine, Cora E. Lewis, Mahboob Rahman, David M. Reboussin, Michael V. Rocco, Su Tags: Hypertension Original Articles Source Type: research
Effect of Lowering Diastolic Pressure in Patients With and Without Cardiovascular DiseaseNovelty and Significance [SPRINT Trial]
Systolic and diastolic blood pressure thresholds, below which cardiovascular events increase, are widely debated. Using data from the SPRINT (Systolic Blood Pressure Intervention Trial), we evaluated the relation between systolic and diastolic pressure and cardiovascular events among 1519 participants with or 7574 without prior cardiovascular disease. Using Cox regression, we examined the composite risk of myocardial infarction, other acute coronary syndrome, stroke, heart failure, or cardiovascular death, and follow-up systolic and diastolic pressure were analyzed as time-dependent covariates for a median of 3.1 years. Mo...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Nadia A. Khan, Simon W. Rabkin, Yinshan Zhao, Finlay A. McAlister, Julie E. Park, Meijiao Guan, Sammy Chan, Karin H. Humphries Tags: Hypertension Original Articles Source Type: research
Intensive Blood Pressure Targets for Diabetic and Other High-Risk PopulationsNovelty and Significance [Epidemiology/Population]
Optimal blood pressure (BP) targets for different populations, especially diabetics, remain uncertain after conflicting data on intensive management. We assessed whether a (Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Rahul Aggarwal, Jackson Steinkamp, Nicholas Chiu, Benjamin Petrie, Haares Mirzan Tags: Hypertension Original Articles Source Type: research
Associations of Initial Injury Severity and Posttraumatic Stress Disorder Diagnoses With Long-Term Hypertension Risk After Combat InjuryNovelty and Significance [Epidemiology/Population]
The associations between injury severity, posttraumatic stress disorder (PTSD), and development of chronic diseases, such as hypertension, among military service members are not understood. We sought to (1) estimate the prevalence and incidence of PTSD within a severely injured military cohort, (2) assess the association between the presence and chronicity of PTSD and hypertension, and (3) determine whether or not initial injury severity score and PTSD are independent risk factors for hypertension. Administrative and clinical databases were used to conduct a retrospective cohort study of 3846 US military casualties injured...
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Jeffrey T. Howard, Jonathan A. Sosnov, Jud C. Janak, Adi V. Gundlapalli, Warren B. Pettey, Lauren E. Walker, Ian J. Stewart Tags: Epidemiology, Risk Factors, Hypertension Original Articles Source Type: research
Relevant Fetal Epigenetic Modifications Result From a Diabetic Intrauterine Environment [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Marco Scioscia Tags: Animal Models of Human Disease, Basic Science Research, Cellular Reprogramming Editorial Commentaries Source Type: research
Pathway for Elimination of Distance Measurement in Studies of Pulse Wave Velocity [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Alberto Avolio, Junli Zuo, Isabella Tan, Mark Butlin Tags: High Blood Pressure Editorial Commentaries Source Type: research
Orthostatic Hypotension in the First Minute After Standing Up [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Veera K. van Wijnen, Mark P.M. Harms, Wouter Wieling Tags: Hypertension Editorial Commentaries Source Type: research
Office Blood Pressure Measurement [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: George Stergiou, Anastasios Kollias, Gianfranco Parati, Eoin O’Brien Tags: High Blood Pressure, Hypertension, Diagnostic Testing Editorial Commentaries Source Type: research
Hypertension, a Posttraumatic Stress Disorder? [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Alexandre Persu, Geraldine Petit, Coralie Georges, Philippe de Timary Tags: Epidemiology, Mental Health, Hypertension Editorial Commentaries Source Type: research
Understanding Angiotensin II Type 1 Receptor Signaling in Vascular Pathophysiology [Lewis K. Dahl Memorial Lecture]
(Source: Hypertension)
Source: Hypertension - April 11, 2018 Category: Cardiology Authors: Satoru Eguchi, Tatsuo Kawai, Rosario Scalia, Victor Rizzo Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Cell Signaling/Signal Transduction Lewis K. Dahl Memorial Lecture Source Type: research
