MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart FailureNovelty and Significance [Heart]
Pressure overload causes cardiac fibroblast activation and transdifferentiation, leading to increased interstitial fibrosis formation and subsequently myocardial stiffness, diastolic and systolic dysfunction, and eventually heart failure. A better understanding of the molecular mechanisms underlying pressure overload–induced cardiac remodeling and fibrosis will have implications for heart failure treatment strategies. The microRNA (miRNA)-221/222 family, consisting of miR-221-3p and miR-222-3p, is differentially regulated in mouse and human cardiac pathology and inversely associated with kidney and liver fibrosis. We inv...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Robin Verȷans, Tim Peters, Francisco Javier Beaumont, Rick van Leeuwen, Tessa van Herwaarden, Wouter Verhesen, Chantal Munts, Mitchell Biȷnen, Michiel Henkens, Javier Diez, Leon J. de Windt, Frans A. van Nieuwenhoven, Marc van Bilsen, Marie Tags: Basic Science Research, Cell Signaling/Signal Transduction, Fibrosis, Heart Failure, Remodeling Original Articles Source Type: research
Three Reportedly Unrelated Families With Liddle Syndrome Inherited From a Common AncestorNovelty and Significance [Genetics]
Liddle syndrome is considered a rare Mendelian hypertension. We have previously described 3 reportedly unrelated families, native of an Italian area around the Strait of Messina, carrying the same mutation (βP617L) of the epithelial sodium channel. The aims of our study were (1) to evaluate whether a close genomic relationship exists between the 3 families through the analysis of mitochondrial DNA and Y chromosome; and (2) to quantify the genomic relatedness between the patients with Liddle syndrome belonging to the 3 families and assess the hypothesis of a mutation shared through identity by descent. HVRI (the hypervaria...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Luca Pagani, Yoan Diekmann, Marco Sazzini, Sara De Fanti, Maurizio Rondinelli, Enrico Farnetti, Bruno Casali, Amelia Caretto, Francesca Novara, Orsetta Zuffardi, Paolo Garagnani, Franco Mantero, Mark G. Thomas, Donata Luiselli, Ermanno Rossi Tags: Cardiovascular Disease, Genetics, Hypertension Original Articles Source Type: research
AK098656, a Novel Vascular Smooth Muscle Cell-Dominant Long Noncoding RNA, Promotes HypertensionNovelty and Significance [Genetics]
Recent studies reported some long noncoding RNAs (lncRNAs)–mediated vascular smooth muscle cells (VSMCs) phenotypic switch, which was a common pathophysiological process of vascular diseases. However, whether human-specific expressed lncRNAs would modulate VSMCs phenotype and participate into the pathogenesis of essential hypertension remains unclear. By comparing the circulating lncRNAs expression profiles between hypertensive patients and healthy controls, we identified a lncRNA-AK098656, strongly upregulated in the plasma of hypertensive patients, and predominantly expressed in VSMCs. AK098656 promoted VSMCs synthetic...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Ling Jin, Xianjuan Lin, Lei Yang, Xiaofang Fan, Wenjie Wang, Shuangyue Li, Jing Li, Xiaoyan Liu, Minghui Bao, Xiao Cui, Jichun Yang, Qinghua Cui, Bin Geng, Jun Cai Tags: Biomarkers, Smooth Muscle Proliferation and Differentiation, Hypertension Original Articles Source Type: research
Predicting Out-of-Office Blood Pressure in the Clinic for the Diagnosis of Hypertension in Primary CareNovelty and Significance [Prediction of Out-of-Office Blood Pressure]
This study assessed the cost-effectiveness of using this tool in diagnosing hypertension in primary care. A Markov cost–utility cohort model was developed to compare diagnostic strategies: the PROOF-BP approach, including those with clinic BP ≥130/80 mm Hg who receive ambulatory BP monitoring as guided by the algorithm, compared with current standard diagnostic strategies including those with clinic BP ≥140/90 mm Hg combined with further monitoring (ambulatory BP monitoring as reference, clinic, and home monitoring also assessed). The model adopted a lifetime horizon with a 3-month time cycle, taking a UK Health Serv...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Mark Monahan, Sue Jowett, Kate Lovibond, Paramjit Gill, Marshall Godwin, Sheila Greenfield, Janet Hanley, F.D. Richard Hobbs, Una Martin, Jonathan Mant, Brian McKinstry, Bryan Williams, James P. Sheppard, Richard J. McManus Tags: High Blood Pressure, Hypertension, Cost-Effectiveness Original Articles Source Type: research
Attended Versus Unattended Blood Pressure Measurement in a Real Life SettingNovelty and Significance [Unattended Blood Pressure Measurement]
The debate on the generalizability of the SPRINT (Systolic Blood Pressure Intervention Trial) findings raised considerable interest in the technique of unattended office blood pressure (BP) measurement. It remains elusive, however, whether unattended BP measurement yields lower values than conventional measurements in a real world setting with subjects consulting their personal general practitioner in a familiar office. We performed a cross-sectional study in 158 patients in 4 general practitioners’ offices and compared conventional auscultatory office BP to unattended automated office BP in 107 subjects (group 1) and un...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Frederic Bauer, Felix S. Seibert, Benjamin Rohn, Klaus A.R. Bauer, Eckart Rolshoven, Nina Babel, Timm H. Westhoff Tags: High Blood Pressure, Hypertension, Blood Pressure Original Articles Source Type: research
Metabolic Predictors of Change in Vascular FunctionNovelty and Significance [Framingham Offspring Study]
We examined relations of longitudinal change in vascular function with change in metabolic traits. Longitudinal changes in vascular function and metabolic traits were examined in 5779 participants (mean age, 49.8±14.5 years; 54% women) who attended sequential examinations of the Framingham Offspring, Third Generation, and Omni-1 and Omni-2 cohorts. Multivariable regression analysis related changes in vascular measures (dependent variables), including carotid-femoral pulse wave velocity (CFPWV), forward pressure wave amplitude, characteristic impedance, central pulse pressure, and mean arterial pressure (MAP), with change ...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Justin P. Zachariah, Jian Rong, Martin G. Larson, Naomi M. Hamburg, Emelia J. Benjamin, Ramachandran S. Vasan, Gary F. Mitchell Tags: Epidemiology, Obesity, Risk Factors, Hypertension Original Articles Source Type: research
Peak Blood Pressure Responses During Maximum Cardiopulmonary Exercise TestingNovelty and Significance [Epidemiology/Population]
The objective of this study is to expand on previous efforts in establishing normative standards of exercising blood pressure (BP) at maximal physical exertion derived from treadmill cardiopulmonary exercise testing in the United States. Four experienced laboratories in the United States with established quality control procedures contributed data from September 1, 1986, to February 1, 2015. A total of 2917 maximal (peak respiratory exchange ratio ≥1.00) treadmill cardiopulmonary exercise testing responses from apparently healthy men and women (aged 20–79 years) without cardiovascular disease were submitted to FRIEND (...
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Ahmad Sabbahi, Ross Arena, Leonard A. Kaminsky, Jonathan Myers, Shane A. Phillips Tags: Aging, Exercise, Risk Factors, High Blood Pressure, Hypertension Original Articles Source Type: research
Correlating Changes in Metabolic Status With Arterial Health [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Paul Welsh Tags: Epidemiology, Risk Factors Editorial Commentaries Source Type: research
The Eye of the Needle [Editorial Commentary]
(Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Leonardo Y. Tanaka, Francisco R.M. Laurindo Tags: Oxidant Stress, Hypertension Editorial Commentaries Source Type: research
Aging and Adrenal Aldosterone Production [Recent Advances in Hypertension]
(Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Kazutaka Nanba, Anand Vaidya, William E. Rainey Tags: ACE/Angiotensin Receptors/Renin Angiotensin System, Genetics, Hypertension Recent Advances in Hypertension Source Type: research
Clinical Implications [Clinical Implications]
(Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Tags: Clinical Implications Source Type: research
Mechanisms of VEGF (Vascular Endothelial Growth Factor) Inhibitor-Associated Hypertension and Vascular Disease [Brief Reviews]
(Source: Hypertension)
Source: Hypertension - January 10, 2018 Category: Cardiology Authors: Arvind K. Pandey, Eric K. Singhi, Juan Pablo Arroyo, Talat Alp Ikizler, Edward R. Gould, Jonathan Brown, Joshua A. Beckman, David G. Harrison, Javid Moslehi Tags: Angiogenesis, Hypertension, Vascular Disease Brief Review Source Type: research
Three-Month Endothelial Human Endothelin-1 Overexpression Causes Blood Pressure Elevation and Vascular and Kidney InjuryNovelty and Significance [Endothelin-1 and End Organ Damage]
Endothelium-derived endothelin (ET)-1 has been implicated in the development of hypertension and end-organ damage, but its exact role remains unclear. We have shown that tamoxifen-inducible endothelium-restricted human ET-1 overexpressing (ieET-1) mice exhibited blood pressure rise after a 3-week induction in an ET type A (ETA) receptor-dependent manner, in absence of vascular and renal injury. It is unknown whether long-term ET-1 overexpression results in sustained blood pressure elevation and vascular and renal injury. Adult male ieET-1 and control tamoxifen-inducible endothelium-restricted Cre recombinase (ieCre) mice w...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Suellen C. Coelho, Olga Berillo, Antoine Caillon, Sofiane Ouerd, Julio C. Fraulob–Aquino, Tlili Barhoumi, Stefan Offermanns, Pierre Paradis, Ernesto L. Schiffrin Tags: Hypertension Original Articles Source Type: research
Myeloid–Derived Suppressor Cells Ameliorate Cyclosporine A–Induced Hypertension in MiceNovelty and Significance [Cyclosporine A-Induced Hypertension]
The calcineurin inhibitor cyclosporine A (CsA) suppresses the immune system but promotes hypertension, vascular dysfunction, and renal damage. CsA decreases regulatory T cells and this contributes to the development of hypertension. However, CsA’s effects on another important regulatory immune cell subset, myeloid-derived suppressor cells (MDSCs), is unknown. We hypothesized that augmenting MDSCs would ameliorate the CsA-induced hypertension and vascular and renal injury and dysfunction and that CsA reduces MDSCs in mice. Daily interleukin-33 treatment, which increased MDSC levels, completely prevented CsA-induced hypert...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Valorie L. Chiasson, Kelsey R. Bounds, Piyali Chatterjee, Lochana Manandhar, Abhinandan R. Pakanati, Marcos Hernandez, Bilal Aziz, Brett M. Mitchell Tags: Basic Science Research, Inflammation, Vascular Biology, Hypertension Original Articles Source Type: research
Exaggerated Vasoconstriction to Spontaneous Bursts of Muscle Sympathetic Nerve Activity in Healthy Young Black MenNovelty and Significance [Sympathetic Nerve Activity]
Blacks have the highest prevalence of hypertension, putting them at greater risk of cardiovascular disease and death. Previous studies have reported that, relative to whites, healthy black men have augmented pressor responses to sympathoexcitatory stressors. Although important, these studies do not inform about the resting state and the influence of spontaneous changes in resting muscle sympathetic nerve activity (MSNA). Likewise, little is known about the transduction of MSNA into a vascular response at rest on a beat-to-beat basis. Accordingly, we tested the hypothesis that relative to whites, blacks would exhibit greate...
Source: Hypertension - December 13, 2017 Category: Cardiology Authors: Jennifer R. Vranish, Seth W. Holwerda, Benjamin E. Young, Daniel P. Credeur, Jordan C. Patik, Thales C. Barbosa, David M. Keller, Paul J. Fadel Tags: Hypertension Original Articles Source Type: research
