Issue Information
(Source: genesis)
Source: genesis - December 18, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
A Pdgf ‐cCreERT2 Knock‐In Mouse Model For Tracing PDGF‐C Cell Lineages During Development
This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - December 1, 2017 Category: Genetics & Stem Cells Authors: Xiaoli Wu, Wenjun Liu, Hao Ding Tags: Technology Report Source Type: research
Generating retinoic acid gradients by local degradation during craniofacial development: One cell's cue is another cell's poison
This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - December 1, 2017 Category: Genetics & Stem Cells Authors: Aditi Dubey, Rebecca E. Rose, Drew R. Jones, Jean ‐Pierre Saint‐Jeannet Tags: Review Source Type: research
Generation and characterization of mice with mesenchyme ‐specific deletion of the entire ESET histone methyltransferase protein
This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - December 1, 2017 Category: Genetics & Stem Cells Authors: Liu Yang, Albert O. Gee, Anna Zielinska ‐Kwiatkowska, Howard A. Chansky Tags: Letter Source Type: research
Issue Information
(Source: genesis)
Source: genesis - November 21, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Development of a bicistronic expression system in the branchiopod crustacean Daphnia magna bicistronic expression system in Daphnia
Summary
The viral 2A peptides have recently been used for bicistronic expression in various organisms. In this system, a single mRNA that codes for two proteins flanking the 2A peptide can be translated simultaneously into each protein by ribosomal skipping at this peptide sequence. Here, we tested the function of the Thosea asigna insect virus 2A (T2A) peptide in the branchiopod crustacean Daphnia magna—an emerging model of evolutionary developmental biology. First, we used transgenic Daphnia that expresses a potential bicistronic RNA containing mCherry and histone H2B‐ green fluorescent protein (GFP) open reading fra...
Source: genesis - November 14, 2017 Category: Genetics & Stem Cells Authors: Hitoshi Kumagai, Tomoaki Matsuura, Yasuhiko Kato, Hajime Watanabe Tags: TECHNOLOGY REPORT Source Type: research
Timing the developmental origins of mammalian limb diversity
Summary
Mammals have highly diverse limbs that have contributed to their occupation of almost every niche. Researchers have long been investigating the development of these diverse limbs, with the goals of identifying developmental processes and potential biases that shape mammalian limb diversity. To date, researchers have used techniques ranging from the genomic to the anatomic to investigate the developmental processes shaping the limb morphology of mammals from five orders (Marsupialia, Chiroptera, Rodentia, Cetartiodactyla, and Perissodactyla). Results of these studies suggest that the differential expression of genes...
Source: genesis - November 2, 2017 Category: Genetics & Stem Cells Authors: Karen Sears, Jennifer A. Maier, Alexa Sadier, Daniel Sorensen, Daniel J. Urban Tags: RESEARCH ARTICLE Source Type: research
Developmental, genetic, and genomic insights into the evolutionary loss of limbs in snakes
Summary
The evolution of snakes involved dramatic modifications to the ancestral lizard body plan. Limb loss and elongation of the trunk are hallmarks of snakes, although convergent evolution of limb‐reduced and trunk‐elongated forms occurred multiple times in snake‐like lizards. Advanced snakes are completely limbless, but intermediate and basal snakes have retained rudiments of hindlimbs and pelvic girdles. Moreover, the snake fossil record indicates that complete legs were re‐acquired at least once, suggesting that the potential for limb development was retained in some limb‐reduced taxa. Recent work has shown...
Source: genesis - November 2, 2017 Category: Genetics & Stem Cells Authors: Francisca Leal, Martin J. Cohn Tags: REVIEW Source Type: research
The mito::mKate2 mouse: A far ‐red fluorescent reporter mouse line for tracking mitochondrial dynamics in vivo
This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - November 1, 2017 Category: Genetics & Stem Cells Authors: Anthony P. Barrasso, Xuefei Tong, Ross A. Poch é Tags: Research Article Source Type: research
Characterization of mice carrying a conditional TEAD1 allele
In conclusion, our data demonstrate an important role of TEAD1 in early development in mice, and the floxed TEAD1 mouse model will be a valuable genetic tool to determine the temporal and tissue‐specific functions of TEAD1. This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - November 1, 2017 Category: Genetics & Stem Cells Authors: Tong Wen, Qin Yin, Luyi Yu, Guoqing Hu, Jinhua Liu, Wei Zhang, Liang Huang, Huabo Su, Menghong Wang, Jiliang Zhou Tags: Technology Report Source Type: research
Znf703, a novel target of Pax3 and Zic1, regulates hindbrain and neural crest development in Xenopus
This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - October 31, 2017 Category: Genetics & Stem Cells Authors: Chang ‐Soo Hong, Jean‐Pierre Saint‐Jeannet Tags: Research Article Source Type: research
Appendages and gene regulatory networks: Lessons from the limbless
Summary
Among squamate reptiles, dozens of lineages have independently evolved complete or partial limb reduction. This remarkable convergence of limbless and limb‐reduced phenotypes provides multiple natural replicates of different ages to explore the evolution and development of the vertebrate limb and the gene regulatory network that controls its formation. The most successful and best known of the limb‐reduced squamates are snakes, which evolved a limb‐reduced body form more than 100 million years ago. Recent studies have revealed the unexpected finding that many ancient limb enhancers are conserved in the genome...
Source: genesis - October 27, 2017 Category: Genetics & Stem Cells Authors: Carlos R. Infante, Ashley M. Rasys, Douglas B. Menke Tags: REVIEW Source Type: research
Review and experimental evaluation of the embryonic development and evolutionary history of flipper development and hyperphalangy in dolphins (Cetacea: Mammalia)
In this study, cetaceans were used as a novel model to review previous studies of mammalian hyperphalangy and contribute new experimental evidence as to the molecular origins of this phenotype in embryos of the pantropical spotted dolphin (Stenella attenuata). Results show embryos of dolphins, mice, and pigs share similar spatiotemporal patterns of signaling proteins known to shape limbs of mammals (e.g., FGF8, BMP2/4, WNT, GREM). However, fetal dolphins differ in that their interdigital tissues are retained, instead of undergoing apoptosis, and that multiple waves of interdigital signals likely contribute to the patternin...
Source: genesis - October 25, 2017 Category: Genetics & Stem Cells Authors: Lisa Noelle Cooper, Karen E. Sears, Brooke A. Armfield, Bhavneet Kala, Merla Hubler, J. G. M. Thewissen Tags: RESEARCH ARTICLE Source Type: research
Issue Information
(Source: genesis)
Source: genesis - October 18, 2017 Category: Genetics & Stem Cells Tags: ISSUE INFORMATION Source Type: research
Generation and characterization of an estrogen receptor alpha ‐iCre knock‐in mouse
This article is protected by copyright. All rights reserved. (Source: genesis)
Source: genesis - October 1, 2017 Category: Genetics & Stem Cells Authors: Chan Jin Park, Guanglin Chen, Yongbum Koo, Po ‐Ching P. Lin, Joseph A. Cacioppo, Hailey Prohaska, CheMyong J. Ko Tags: Technology Report Source Type: research
