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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 20, 2017 Category: Genetics & Stem Cells Source Type: research
The genetics of human personality
Personality traits are the relatively enduring patterns of thoughts, feelings, and behaviors that reflect the tendency to respond in certain ways under certain circumstances. Twin and family studies have demonstrated that personality traits are moderately heritable, and can predict various lifetime outcomes, including psychopathology. The Research Domain Criteria (RDoC) characterizes psychiatric diseases as extremes of normal tendencies, including specific personality traits. This implies that heritable variation in personality traits, such as neuroticism, would share a common genetic basis with psychiatric diseases, such ...
Source: Genes, Brain and Behavior - November 20, 2017 Category: Genetics & Stem Cells Authors: Sandra Sanchez ‐Roige, Joshua C Gray, James K MacKillop, Chi‐Hua Chen, Abraham A Palmer Tags: REVIEW Source Type: research
The emerging role of mRNA methylation in normal and pathological behavior
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 17, 2017 Category: Genetics & Stem Cells Source Type: research
Behavioral control by striatal adenosine A2A ‐dopamine D2 receptor heteromers
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 17, 2017 Category: Genetics & Stem Cells Source Type: research
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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 17, 2017 Category: Genetics & Stem Cells Source Type: research
Behavioral control by striatal adenosine A2A ‐dopamine D2 receptor heteromers
G protein‐coupled receptors (GPCR) exhibit the ability to form receptor complexes that include molecularly different GPCR (ie, GPCR heteromers), which endow them with singular functional and pharmacological characteristics. The relative expression of GPCR heteromers remains a matter of intense debate. Recent studies support that adenosine A2A receptors (A2AR) and dopamine D2 receptors (D2R) predominantly form A2AR‐D2R heteromers in the striatum. The aim of the present study was evaluating the behavioral effects of pharmacological manipulation and genetic blockade of A2AR and D2R within the frame of such a predominant s...
Source: Genes, Brain and Behavior - November 17, 2017 Category: Genetics & Stem Cells Authors: J. Taura, M. Valle ‐León, K. Sahlholm, M. Watanabe, K. Van Craenenbroeck, V. Fernández‐Dueñas, S. Ferré, F. Ciruela Tags: ORIGINAL ARTICLE Source Type: research
Referees List for Volume 16
(Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 8, 2017 Category: Genetics & Stem Cells Tags: Referees Source Type: research
Corrigendum
(Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 8, 2017 Category: Genetics & Stem Cells Tags: Corrigendum Source Type: research
Issue Information
(Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 8, 2017 Category: Genetics & Stem Cells Tags: Issue Information Source Type: research
Npas4 deficiency interacts with adolescent stress to disrupt prefrontal GABAergic maturation and adult cognitive flexibility
Abstract
Healthy cognitive and emotional functioning relies on a balance between excitatory and inhibitory neurotransmission in the prefrontal cortex. This balance is largely established during early postnatal and adolescent developmental periods by maturation of the γ‐aminobutyric acid (GABA) system, including increased density of parvalbumin cells and perineuronal nets. Genetic and/or environmental factors during adolescence can disrupt GABAergic maturation and lead to behavioral dysfunction in adulthood. The present study examined the interaction between chronic mild stress during adolescence and genetic deficiency o...
Source: Genes, Brain and Behavior - November 1, 2017 Category: Genetics & Stem Cells Authors: Chloe Page, Jonathan Alexander, Ryan Shepard, Laurence Coutellier Tags: ORIGINAL ARTICLE Source Type: research
P2Y12 deficiency in mouse impairs noradrenergic system in brain, and alters anxiety ‐like neurobehavior and memory
Abstract
Purinergic receptor P2Y12 (P2Y12), a G protein‐coupled (GPCR) purinergic receptor, is widely distributed in nervous system and involved in the progression of neurological diseases such as multiple sclerosis and neuropathic pain. The central noradrenergic system actively participates in a number of neurophysiological processes. Nevertheless, whether there is any direct relevance between P2Y12 and noradrenergic signal transduction remains unknown. In the present study, we tested the hypothesis that lack of P2Y12 impaired noradrenergic signal transduction in mouse brain. Our results showed that P2Y12 knockout mice ...
Source: Genes, Brain and Behavior - November 1, 2017 Category: Genetics & Stem Cells Authors: Fang Zheng, Qiang Zhou, Yin Cao, Hailian Shi, Hui Wu, Beibei Zhang, Fei Huang, Xiaojun Wu Tags: ORIGINAL ARTICLE Source Type: research
Autophosphorylation of αCaMKII affects social interactions in mice
Abstract
The α‐Ca2+/calmodulin‐dependent protein kinase II (αCaMKII), a key regulator of the glutamatergic synapse, has been implicated in many psychiatric disorders characterized by social impairments. Here we tested whether autophosphorylation of αCaMKII at threonine 286, which prolongs the activity of the enzyme, affects social behaviors in mice. We observed that autophosphorylation‐deficient (αCaMKII‐T286A) mutant female mice showed abnormal social behaviors characterized by decreased social preference and interest in conspecifics of the same sex, as compared to their wild‐type littermates. Moreover, we d...
Source: Genes, Brain and Behavior - November 1, 2017 Category: Genetics & Stem Cells Authors: Zofia Harda, Jakub Mateusz Dzik, Maria Nalberczak ‐Skóra, Ksenia Meyza, Kacper Łukasiewicz, Szymon Łęski, Kasia Radwanska Tags: ORIGINAL ARTICLE Source Type: research
Novel mutations and phenotypes of epilepsy ‐associated genes in epileptic encephalopathies
This study highlighted the utility of targeted next‐generation sequencing in genetic diagnoses of epileptic encephalopathies and a comprehensive evaluation of the pathogenicity of variants based on ACMG scoring and assessment of clinical concordance. Epileptic encephalopathies differ in genetic causes, and the genotype–phenotype correlations would provide insights into the underlying pathogenic mechanisms. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 1, 2017 Category: Genetics & Stem Cells Authors: Peng Zhou, Na He, Jing ‐Wen Zhang, Zhi‐Jian Lin, Jie Wang, Li‐Min Yan, Heng Meng, Bin Tang, Bing‐Mei Li, Xiao‐Rong Liu, Yi‐Wu Shi, Qiong‐Xiang Zhai, Yong‐Hong Yi, Wei‐Ping Liao Tags: ORIGINAL ARTICLE Source Type: research
Neuronal RNA ‐binding protein HuD regulates addiction‐related gene expression and behavior
Abstract
The neuronal RNA‐binding protein HuD is involved in synaptic plasticity and learning and memory mechanisms. These effects are thought to be due to HuD‐mediated stabilization and translation of target mRNAs associated with plasticity. To investigate the potential role of HuD in drug addiction, we first used bioinformatics prediction algorithms together with microarray analyses to search for specific genes and functional networks upregulated within the forebrain of HuD overexpressing mice (HuDOE). When this set was further limited to genes in the Knowledgebase of Addiction Related Genes database (KARG) that cont...
Source: Genes, Brain and Behavior - November 1, 2017 Category: Genetics & Stem Cells Authors: Robert J. Oliver, Jonathan L. Brigman, Federico Bolognani, Andrea M. Allan, Janet L. Neisewander, Nora I. Perrone ‐Bizzozero Tags: ORIGINAL ARTICLE Source Type: research
