Perinatal nutrition interacts with genetic background to alter behavior in a parent ‐of‐origin‐dependent manner in adult Collaborative Cross mice
Previous studies in animal models and humans have shown that exposure to nutritional deficiencies in the perinatal period increases the risk of psychiatric disease. Less well understood is how such effects are modulated by the combination of genetic background and parent‐of‐origin (PO). To explore this, we exposed female mice from 20 Collaborative Cross (CC) strains to protein deficient, vitamin D deficient, methyl donor enriched or standard diet during the perinatal period. These CC females were then crossed to a male from a different CC strain to produce reciprocal F1 hybrid females comprising 10 distinct genetic bac...
Source: Genes, Brain and Behavior - December 13, 2017 Category: Genetics & Stem Cells Authors: S. A. Schoenrock, D. Oreper, J. Farrington, R. C. McMullan, R. Ervin, D. R. Miller, F. Pardo ‐Manuel de Villena, W. Valdar, L. M. Tarantino Tags: ORIGINAL ARTICLE Source Type: research
Post ‐GWAS in Psychiatric Genetics: A Developmental Perspective on the “Other” Next Steps
Abstract
As psychiatric genetics enters an era where gene identification is finally yielding robust, replicable genetic associations and polygenic risk scores, it is important to consider next steps and delineate how that knowledge will be applied to ultimately ameliorate suffering associated with substance use and psychiatric disorders. Much of the post‐GWAS discussion has focused on the potential of genetic information to elucidate the underlying biology and use this information for the development of more effective pharmaceutical treatments. In this review we focus on additional areas of research that should follow ge...
Source: Genes, Brain and Behavior - December 11, 2017 Category: Genetics & Stem Cells Authors: Danielle M. Dick, , Peter B. Barr, Seung Bin Cho, Megan E. Cooke, Sally I ‐Chun Kuo, Tenesha J. Lewis, Zoe Neale, Jessica E. Salvatore, Jeanne Savage, Jinni Su Tags: REVIEW Source Type: research
Npas4 deficiency and prenatal stress interact to affect social recognition in mice
ABSTRACT
Neurodevelopmental disorders such as autism spectrum disorders and schizophrenia have an expansive array of reported genetic and environmental contributing factors. However, none of these factors alone can account for a substantial proportion of cases of either disorder. Instead, many gene‐by‐environment interactions are responsible for neurodevelopmental disturbances that lead to these disorders. The current experiment used heterozygous knock‐out mice to examine a potential interaction between two factors commonly linked to neurodevelopmental disorders and cognitive deficit: imbalanced excitatory/inhibitory...
Source: Genes, Brain and Behavior - December 11, 2017 Category: Genetics & Stem Cells Authors: Kelsey Heslin, Laurence Coutellier Tags: ORIGINAL ARTICLE Source Type: research
Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co ‐occurring traits
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - December 6, 2017 Category: Genetics & Stem Cells Source Type: research
The contribution of alternative splicing to genetic risk for psychiatric disorders
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - December 6, 2017 Category: Genetics & Stem Cells Source Type: research
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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - December 6, 2017 Category: Genetics & Stem Cells Source Type: research
Quantitative trait locus mapping and analysis of heritable variation in affiliative social behavior and co ‐occurring traits
Humans exhibit broad heterogeneity in affiliative social behavior. Twin and family studies show that individual differences in core dimensions of social behavior are heritable, yet there are knowledge gaps in understanding the underlying genetic and neurobiological mechanisms. Animal genetic reference panels (GRPs) provide a tractable strategy for examining the behavioral and genetic architecture of complex traits. Here, using males from 50 mouse strains from the BXD GRP, 4 domains of affiliative social behavior—social approach, social recognition, direct social interaction (DSI) (partner sniffing) and vocal communicatio...
Source: Genes, Brain and Behavior - December 6, 2017 Category: Genetics & Stem Cells Authors: A. T. Knoll, K. Jiang, P. Levitt Tags: ORIGINAL ARTICLE Source Type: research
Genetic loss of diazepam binding inhibitor in mice impairs social interest
Abstract
Neuropsychiatric disorders in which reduced social interest is a common symptom, such as autism, depression, and anxiety, are frequently associated with genetic mutations affecting GABAergic transmission. Benzodiazepine treatment, acting via GABAA receptors, improves social interaction in male mouse models with autism‐like features. The protein diazepam binding inhibitor (DBI) can act as an endogenous benzodiazepine, but a role for DBI in social behavior has not been described. Here we investigated the role of DBI in the social interest and recognition behavior of mice. The responses of DBI wild‐type and knock...
Source: Genes, Brain and Behavior - November 28, 2017 Category: Genetics & Stem Cells Authors: A.L. Ujjainwala, C.D. Courtney, S.G. Rhoads, J.S. Rhodes, C.A. Christian Tags: ORIGINAL ARTICLE Source Type: research
Atp1a3 ‐deficient heterozygous mice show lower rank in the hierarchy and altered social behavior
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 24, 2017 Category: Genetics & Stem Cells Source Type: research
Potential of microRNAs as novel targets in the alleviation of pathological fear
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 24, 2017 Category: Genetics & Stem Cells Source Type: research
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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 24, 2017 Category: Genetics & Stem Cells Source Type: research
Atp1a3 ‐deficient heterozygous mice show lower rank in the hierarchy and altered social behavior
Atp1a3 is the Na‐pump alpha3 subunit gene expressed mainly in neurons of the brain. Atp1a3‐deficient heterozygous mice (Atp1a3+/−) show altered neurotransmission and deficits of motor function after stress loading. To understand the function of Atp1a3 in a social hierarchy, we evaluated social behaviors (social interaction, aggression, social approach and social dominance) of Atp1a3+/− and compared the rank and hierarchy structure between Atp1a3+/− and wild‐type mice within a housing cage using the round‐robin tube test and barbering observations. Formation of a hierarchy decreases social conflict and promote...
Source: Genes, Brain and Behavior - November 24, 2017 Category: Genetics & Stem Cells Authors: H. Sugimoto, K. Ikeda, K. Kawakami Tags: ORIGINAL ARTICLE Source Type: research
Variants regulating ZBTB4 are associated with age ‐at‐onset of Alzheimer's disease
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - November 20, 2017 Category: Genetics & Stem Cells Source Type: research
