Single point mutation on the gene encoding dysbindin results in recognition deficits
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - January 11, 2018 Category: Genetics & Stem Cells Source Type: research
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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - January 11, 2018 Category: Genetics & Stem Cells Source Type: research
A role for activity ‐dependent epigenetics in the development and treatment of major depressive disorder
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - January 9, 2018 Category: Genetics & Stem Cells Source Type: research
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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - January 9, 2018 Category: Genetics & Stem Cells Source Type: research
A role for activity ‐dependent epigenetics in the development and treatment of major depressive disorder
Chronic stressors, during developmental sensitive periods and beyond, contribute to the risk of developing psychiatric conditions, including major depressive disorder (MDD). Epigenetic mechanisms including DNA methylation and histone modifications, at key stress response and neurotrophin genes, are increasingly implicated in mediating this risk. Although the exact mechanisms through which stressful environmental stimuli alter the epigenome are still unclear, research from the learning and memory fields indicates that epigenomic marks can be altered, at least in part, through calcium‐dependent signaling cascades in direct...
Source: Genes, Brain and Behavior - January 9, 2018 Category: Genetics & Stem Cells Authors: C. Nagy, K. Vaillancourt, G. Turecki Tags: REVIEW Source Type: research
Npas4 deficiency and prenatal stress interact to affect social recognition in mice
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Source Type: research
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Genes, Brain and Behavior, Ahead of Print. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Source Type: research
A QTL on chromosome 1 modulates inter ‐male aggression in mice
In this study the BXD recombinant inbred mouse strains (RIS) were used to map quantitative trait loci (QTLs) underlying behaviors associated with intermale aggression. Four hundred and fifty‐seven males from 55 strains (including the parentals) were observed at an age of 13 +/‐ 1 week in a resident‐intruder test following 10 days of isolation. Attack latency was measured directly within a 10 minute time period and the test was repeated 24 hours later. The variables we analyzed were the proportion of attacking males in a given strain as well as the attack latency (on days 1 and 2, and both days combined). On day 1, 29...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Anna Delprato, Brice Bonheur, Marie ‐Paule Algéo, Alba Murillo, Esha Dhawan, Lu Lu, Robert W. Williams, Wim E. Crusio Tags: ORIGINAL ARTICLE Source Type: research
Conditional Deletion of Cadherin ‐13 Perturbs Golgi Cells and Disrupts Social and Cognitive Behaviors
Abstract
Inhibitory interneurons mediate the gating of synaptic transmission and modulate the activities of neural circuits. Disruption of the function of inhibitory networks in the forebrain is linked to impairment of social and cognitive behaviors, but the involvement of inhibitory interneurons in the cerebellum has not been assessed. We found that Cadherin 13 (Cdh13), a gene implicated in autism spectrum disorder and attention‐deficit hyperactivity disorder, is specifically expressed in Golgi cells within the cerebelluar cortex. To assess the function of Cdh13 and utilize the manipulation of Cdh13 expression in Golgi ...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Martesa Tantra, Lanboling Guo, Jinsook Kim, Norliyana Zainolabidin, George J. Augustine, Volker Eulenburg, Albert I. Chen Tags: ORIGINAL ARTICLE Source Type: research
Dynorphinergic system alterations in the corticostriatal circuitry of neuropathic mice supports its role in the negative affective component of pain
Abstract
The dynorphinergic system is involved in pain transmission at spinal level, where dynorphin exerts antinociceptive or pronociceptive effects, based on its opioid or non‐opioid actions. Surprisingly, little evidence is currently available concerning the supraspinal role of the dynorphinergic system in pain conditions.
The present study aimed to investigate whether neuropathic pain is accompanied by prodynorphin (Pdyn) and κ‐opioid receptor (Oprk1) gene expression alterations in selected mouse brain areas. To this end, mice were subjected to chronic constriction injury of the right sciatic nerve and neuropathic...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Palmisano Martina, Caputi Francesca Felicia, Mercatelli Daniela, Romualdi Patrizia, Candeletti Sanzio Tags: ORIGINAL ARTICLE Source Type: research
No evidence of association of oxytocin polymorphisms with breastfeeding in two independent samples
Abstract
Oxytocin has an important function in breastfeeding via its role in the milk ejection reflex and in attachment and bonding processes. Genetic factors account for a significant part of the individual differences in breastfeeding behaviour. OXT and OXTR have been proposed as gene candidates for breastfeeding. Previous studies have focused on certain single nucleotide polymorphisms (SNPs) within these genes, finding null or inconsistent results. The present study analyses the associations between a wide coverage of polymorphisms in OXT and OXTR and breastfeeding duration from two large and independent unselected samp...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Luc ía Colodro‐Conde, Juan F. Sanchez‐Romera, Penelope A. Lind, Gu Zhu, Nicholas G. Martin, Sarah E. Medland, Juan R. Ordoñana Tags: ORIGINAL ARTICLE Source Type: research
The nature of social cognitive deficits in children and adults with Klinefelter syndrome (47,XXY)
This study was designed to assess types of cognitive deficits in individuals with 47,XXY that may contribute to social‐emotional dysfunction, and to evaluate the nature of such deficits at various levels: ranging from basic visuo‐spatial processing deficits, impairments in face recognition, to emotion expression impairments.
A total of 70 boys and men with 47,XXY, aged 8 to 60 years old, participated in the study. The subtests Feature Identification (FI), Face Recognition (FR) and Identification of Facial Emotions (IFE) of the Amsterdam Neuropsychological Tasks were used. Level of intellectual functioning was assessed ...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Sophie van Rijn, Leo de Sonneville, Hanna Swaab Tags: ORIGINAL ARTICLE Source Type: research
Cognitive deficits and increases in creatine precursors in a brain ‐specific knockout of the creatine transporter gene Slc6a8
Abstract
Creatine transporter (CrT; SLC6A8) deficiency (CTD) is an X‐linked disorder characterized by severe cognitive deficits, impairments in language, and an absence of brain creatine (Cr). In a previous study, we generated floxed Slc6a8 (Slc6a8flox) mice to create ubiquitous Slc6a8 knockout (Slc6a8‐/y) mice. Slc6a8‐/y mice lacked whole body Cr and exhibited cognitive deficits. While Slc6a8‐/y mice have a similar biochemical phenotype to CTD patients, they also showed a reduction in size and reductions in swim speed that may have contributed to the observed deficits. To address this, we created brain‐specific ...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Kenea C. Udobi, Amanda N. Kokenge, Emily R. Hautman, Gabriela Ullio, Julie Coene, Michael T. Williams, Charles V. Vorhees, Alo ïse Mabondzo, Matthew R. Skelton Tags: ORIGINAL ARTICLE Source Type: research
Domperidone up ‐regulates dopamine receptor expression and stimulates locomotor activity in larval zebrafish (Danio rerio)
The objectives of this study were to (1) quantify the temporal expression of transcripts (dopamine receptors, transporters, and tyrosine hydroxylase) associated with dopamine signaling during early stages of zebrafish development and to (2) determine their expression profiles following treatment with a D2 receptor antagonist domperidone (DMP). We also assessed locomotor behavior following treatment with domperidone using alternating periods of light and dark (i.e. dark photokinesis), as dopamine plays a key role in behavior. Relative expression levels of transcripts that were investigated and related to the dopamine system...
Source: Genes, Brain and Behavior - January 1, 2018 Category: Genetics & Stem Cells Authors: Edward C. Shontz, Christopher L. Souders II, Jordan T. Schmidt, Christopher J. Martyniuk Tags: ORIGINAL ARTICLE Source Type: research
The genetics of human personality
Genes, Brain and Behavior, EarlyView. (Source: Genes, Brain and Behavior)
Source: Genes, Brain and Behavior - December 29, 2017 Category: Genetics & Stem Cells Source Type: research
