European Journal of Clinical Investigation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Survivin is a negative prognostic factor in malignant pleural effusion
ConclusionElevated pleural fluid survivin concentrations are useful to predict failure of pleurodesis and are associated with shorter survival in patients with malignant pleural effusion.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: Elena Arellano ‐Orden, Beatriz Romero‐Romero, Verónica Sánchez‐López, José Martín‐Juan, Francisco Rodríguez‐Panadero, Remedios Otero‐Candelera Tags: Original Paper Source Type: research

Heart rate as a predictor of cardiovascular risk
ConclusionHR has an important negative effect on cardio‐ and cerebrovascular morbidity and mortality. Future longitudinal investigations should clarify HR significance and optimal HR reduction for primary and secondary prevention in cardio‐ and cerebrovascular events.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: Marijana Tadic, Cesare Cuspidi, Guido Grassi Tags: Review Source Type: research

Apelin ‐13 treatment enhances the stability of atherosclerotic plaques
ConclusionsApelin‐13 treatment for 3 weeks did not alter the lesion size, but it significantly enhanced the stable phenotype of atherosclerotic plaques and improved serum lipid profile. These results indicate that activation of apelin system decreases plaque vulnerability.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: Rodrigo Araujo Fraga ‐Silva, Hugo Seeman, Fabrizio Montecucco, Analina Raquel da Silva, Fabienne Burger, Fabiana Pereira Costa‐Fraga, Léa Anguenot, François Mach, Robson Augusto Souza dos Santos, Nikolaos Stergiopulos, Rafaela Fernandes da Silva Tags: Original Paper Source Type: research

Title: Prognostic significance of arterial stiffness and osteoprotegerin in patients with stable coronary artery disease
ConclusionsThese findings extend the current knowledge concerning the role of arterial stiffness as powerful biomarkers in cardiovascular disease. Measurement of PWV might have a role in ascertaining prognosis and managing treatment in patients with stable CAD after PCI.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: Gerasimos Siasos, Evangelos Oikonomou, Konstantinos Maniatis, Georgios Georgiopoulos, Eleni Kokkou, Vasiliki Tsigkou, Marina Zaromitidou, Alexis Antonopoulos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G. Papavassiliou, Dimitris Tousoulis Tags: Original Paper Source Type: research

Electronic Registry for the Management of Childhood Obesity in Greece
ConclusionsThis National eHealth System appears to be effective in the management of overweight and obesity in childhood and adolescence.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: Penio Kassari, Panagiotis Papaioannou, Antonis Billiris, Haralampos Karanikas, Stergiani Eleftheriou, Eleftherios Thireos, Yannis Manios, George P. Chrousos, Evangelia Charmandari Tags: Original Paper Source Type: research

Soluble ST2 in end ‐stage heart failure, before and after support with a left ventricular assist device
ConclusionLevels of sST2 are elevated in end‐stage HF patients with variability that suggests multiple inputs to a pro‐inflammatory and pro‐fibrotic pathway. Cardiogenic shock and increased CRP levels are associated with higher sST2 levels. LVAD support results in a significant drop in sST2 levels with normalization within 3 months post implantation. This suggests that LVAD support leads to lessening of fibrosis and inflammation, which might eventually be used to target medical policy: explantation of the LVAD versus permanent use or cardiac transplantation.This article is protected by copyright. All rights reserved....
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: C.C.S. Tseng, M.M.H. Huibers, L. H. Gaykema, E. Siera ‐de Koning, F.Z. Ramjankhan, A.S. Maisel, N. de Jonge Tags: Original Paper Source Type: research

Cardiorespiratory fitness and age ‐related arterial stiffness in lupus
ConclusionsThe results of the present study suggest that cardiorespiratory fitness attenuates the age‐related arterial stiffening in women with systemic lupus erythematosus and might thus contribute to the primary prevention of cardiovascular disease in this population. Since the cross‐sectional design precludes establishing causal relationships, future clinical trials should confirm or contrast these findings.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - January 1, 2018 Category: General Medicine Authors: Cristina Montalb án‐Méndez, Alberto Soriano‐Maldonado, José Antonio Vargas‐Hitos, Luis Manuel Sáez‐Urán, Antonio Rosales‐Castillo, Pablo Morillas‐de‐Laguno, Blanca Gavilán‐Carrera, Juan Jiménez‐Alonso Tags: Original Paper Source Type: research

CHA2DS2 ‐VASc scores for outcomes prediction in acute ischemic stroke
ConclusionsPre‐stroke CHA2DS2‐VASc scores appear to have better clinical value for predicting the severity of infarction and long‐term clinical outcomes in acute ischemic stroke patients with and without AF.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 30, 2017 Category: General Medicine Authors: Chun ‐Hung Su, Teng‐Fu Tsao, An‐Chih Chen, Kai‐Wei Chang, Yi‐Sun Yang, Kwo‐Chang Ueng, Chin‐Feng Tsai Tags: Original Paper Source Type: research

Announcement
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 27, 2017 Category: General Medicine Tags: ANNOUNCEMENT Source Type: research

Issue Information
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 27, 2017 Category: General Medicine Tags: ISSUE INFORMATION Source Type: research

A totally new system is needed for drug research and development
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 27, 2017 Category: General Medicine Authors: Peter C. G øtzsche Tags: Commentary Source Type: research

Comment on: Complement C3 and fatty liver disease in Rheumatoid arthritis patients: a  cross‐sectional study
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 21, 2017 Category: General Medicine Authors: Fatemeh Khosravi Shadmani, Salman Khazaei, Shiva Mansouri Hanis, Kamyar Mansori Tags: Letter Source Type: research

Patients not patents: drug research and development as a public enterprise
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 15, 2017 Category: General Medicine Authors: Peter C. G øtzsche Tags: Perspective Source Type: research

Pulmonary Arterial Hypertension Associated with Connective Tissue Diseases: A Review Focusing on Distinctive Clinical Aspects
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 15, 2017 Category: General Medicine Authors: Masaru Kato, Tatsuya Atsumi Tags: Review Source Type: research

High ‐density lipoprotein from end‐stage renal disease patients exhibits superior cardioprotection and increase in sphingosine‐1‐phosphate
In this study, we compared plasma levels of sphingosine‐1‐phosphate (S1P), HDL‐associated S1P (HDL‐S1P) and HDL‐mediated protection against oxidative stress between CKD and control patients. MethodsHigh‐density lipoprotein was individually isolated from 20 CKD patients and 20 controls. Plasma S1P, apolipoprotein M (apoM) concentrations, HDL‐S1P content and the capacity of HDL to protect cardiomyocytes against doxorubicin‐induced oxidative stress in vitro were measured. ResultsChronic kidney disease patients showed a typical profile with significant reductions in plasma HDL cholesterol and albumin and an in...
Source: European Journal of Clinical Investigation - December 14, 2017 Category: General Medicine Authors: Jonas W. Brinck, Aur élien Thomas, Marie‐Claude Brulhart‐Meynet, Estelle Lauer, Cecilia Frej, Björn Dahlbäck, Peter Stenvinkel, Richard W. James, Miguel A. Frias Tags: ORIGINAL ARTICLE Source Type: research