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Issue Information
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 28, 2017 Category: General Medicine Tags: Issue Information Source Type: research

MicroRNA ‐145 regulates disabled‐2 and Wnt3a expression in cardiomyocytes under hyperglycemia
ConclusionsAng II downregulates miR‐145 to regulate Dab2 and Wnt3a/ß‐catenin expression in cardiomyocytes under high glucose concentration. Ang II plays a critical role in the regulation of miR‐145 in cardiomyocytes under hyperglycemic conditions.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 25, 2017 Category: General Medicine Authors: Bao ‐Wei Wang, Wei‐Jen Fang, Kou‐Gi Shyu Tags: Original Paper Source Type: research

E ‐Selectin Gene in Essential Hypertension: A Case‐Control Study
ConclusionsA significant association of E‐selectin (Leu554Phe) gene and increased expression of E‐selectin gene at mRNA and protein levels in patients might be related with the genetic predisposition to develop essential hypertension.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 25, 2017 Category: General Medicine Authors: Kamna Srivastava, Sudhir Chandra, Rajiv Narang, Jagriti Bhatia, Daman Saluja Tags: Original Paper Source Type: research

Tophus size is associated with hallux valgus deformity in gout
ConclusionsOur results confirm a high prevalence of HV in gouty patients. We also observed a correlation between the size of the US tophus and the angles defining HV, which suggests a link between urate deposition load and HV. Early urate‐lowering therapy for gout could limit the occurrence of HV.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 24, 2017 Category: General Medicine Authors: Camille Blandin, Marine Forien, Anais Gardette, Elisabeth Palazzo, Philippe Dieud é, Sébastien Ottaviani Tags: Original Paper Source Type: research

Decreased platelet inhibition by P2Y12 receptor blockers in anemia
ConclusionAnemia is associated with decreased platelet inhibition by ADP P2Y12 receptor antagonists after elective and acute percutaneous interventions with stent implantation. However, due to inconsistencies between different platelet function tests additional data are needed to clarify the role of anemia for platelet inhibition.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 24, 2017 Category: General Medicine Authors: Patricia P. Wadowski, Christoph W. Kopp, Renate Koppensteiner, Irene M. Lang, Joseph Pultar, Silvia Lee, Constantin Weikert, Simon Panzer, Thomas Gremmel Tags: Original Paper Source Type: research

Serum paraoxonase ‐1 activity is inversely related to free thyroxine in euthyroid subjects: The PREVEND Cohort Study
ConclusionsSerum PON‐1 activity is inversely associated with free T4 in euthyroid subjects, suggesting that low‐normal thyroid function may affect PON‐1 regulation.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 24, 2017 Category: General Medicine Authors: Lynnda J.N. van Tienhoven ‐Wind, Eke G. Gruppen, Richard W. James, Stephan J.L. Bakker, Rijk O.B. Gans, Robin P.F. Dullaart Tags: Original Paper Source Type: research

Association of oxidative stress with clinical characteristics in patients with rheumatoid arthritis
ConclusionThe preliminary results demonstrate that plasma NSSA levels were inversely correlated with tender and swollen joints count and DAS28 and that NSSA was independently associated with DAS28, in RA patients treated with traditional DMARDs; and provide initial support that NSSA may be used as a biomarker of disease activity in RA patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 16, 2017 Category: General Medicine Authors: Sinan Karde ş, Mine Karagülle, İlker Durak, Aslıhan Avcı, Müfit Zeki Karagülle Tags: Original Paper Source Type: research

A translational evidence for cholesteryl ester transfer protein (CETP) modulation by glucocorticoids: a time for reflection
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 13, 2017 Category: General Medicine Authors: Luca Liberale, Fabrizio Montecucco, Aldo Bonaventura Tags: Commentary Source Type: research

The dilemma of monotherapy or combination therapy in community ‐acquired pneumonia
ConclusionDue to the considerable heterogeneity and inclusion of unadjusted data, it is difficult to recommend a specific antibiotic regimen over another. Specific antibiotic regimens, study design and the characteristics of the population under study seem to influence the reported outcomes. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 9, 2017 Category: General Medicine Authors: Konstantinos Z. Vardakas, Kyriakos K. Trigkidis, Katerina N. Apiranthiti, Matthew E. Falagas Tags: REVIEW Source Type: research

Effect of enterovirus infections on asthma in young children: A  national cohort study
ConclusionThe incidence of asthma was higher in the EV cohort than in the non‐EV cohort, comprising children aged ≤5 years, regardless of sex, urbanization level, parental occupation or season. In particular, the risk of asthma was higher in children with a higher frequency of admission, even in the absence of atopy or other respiratory infections. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 7, 2017 Category: General Medicine Authors: Jun ‐Jun Yeh, Cheng‐Li Lin, Wu‐Huei Hsu Tags: ORIGINAL ARTICLE Source Type: research

HDL from end ‐stage renal disease patients exhibits superior cardioprotection and increase in S1P
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 1, 2017 Category: General Medicine Authors: Jonas W. Brinck, Aur élien Thomas, Marie‐Claude Brulhart‐Meynet, Estelle Lauer, Cecilia Frej, Björn Dahlbäck, Peter Stenvinkel, Richard W. James, Miguel A. Frias Tags: Original Paper Source Type: research

Sublingual functional capillary rarefaction in chronic heart failure
ConclusionCHF patients have got a markedly lower functional and total perfused capillary density in sublingual microvasculature when compared to controls, indicating a systemic decrease in microcirculation.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 1, 2017 Category: General Medicine Authors: Patricia P. Wadowski, Martin H ülsmann, Christian Schörgenhofer, Irene M. Lang, Raphael Wurm, Thomas Gremmel, Renate Koppensteiner, Barbara Steinlechner, Michael Schwameis, Bernd Jilma Tags: Original Paper Source Type: research

Cytokine responses, microbial etiology and short ‐term outcome in community‐acquired pneumonia
ConclusionsIn this CAP cohort, admission levels of IL‐6, IL‐8 and MIP‐1β were associated with disease severity and/or adverse short‐term outcome. Still, for most mediators, only non‐significant variations in inflammatory responses were observed for groups of microbial etiology, disease severity and short‐term outcome.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 1, 2017 Category: General Medicine Authors: William W. Siljan, Jan C. Holter, St åle H. Nymo, Einar Husebye, Thor Ueland, Pål Aukrust, Tom E. Mollnes, Lars Heggelund Tags: Original Paper Source Type: research

Treatment of Helicobacter pylori infection: a clinical practice update
ConclusionsCurrent international guidelines are consistent in defining treatment strategies for Helicobacter pylori infection. The use of national registries to monitor the efficacy and tolerability of different regimens in the real word of clinical practice is now needed.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 1, 2017 Category: General Medicine Authors: Rocco Maurizio Zagari, Stefano Rabitti, Leonardo Henry Eusebi, Franco Bazzoli Tags: Review Source Type: research

A critical role of Pentraxin 3 in severe sepsis and septic shock
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 1, 2017 Category: General Medicine Authors: Federico Carbone, Fabrizio Montecucco, Fabio Rigamonti Tags: Commentary Source Type: research