European Journal of Clinical Investigation This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Methylation ‐based estimated biological age and cardiovascular disease
ConclusionsDNA methylation‐based estimation of “biological age” per Horvath was associated with incident cardiovascular disease.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 12, 2017 Category: General Medicine Authors: Lars Lind, Erik Ingelsson, Johan Sundstr öm, Agneta Siegbahn, Erik Lampa Tags: Original Paper Source Type: research

MicroRNA ‐145 regulates disabled‐2 and Wnt3a expression in cardiomyocytes under hyperglycaemia
ConclusionsAng II downregulates miR‐145 to regulate Dab2 and Wnt3a/ß‐catenin expression in cardiomyocytes under high glucose concentration. Ang II plays a critical role in the regulation of miR‐145 in cardiomyocytes under hyperglycaemic conditions. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 8, 2017 Category: General Medicine Authors: Bao ‐Wei Wang, Wei‐Jen Fang, Kou‐Gi Shyu Tags: ORIGINAL ARTICLE Source Type: research

Cytokine responses, microbial aetiology and short ‐term outcome in community‐acquired pneumonia
ConclusionsIn this CAP cohort, admission levels of IL‐6, IL‐8 and MIP‐1β were associated with disease severity and/or adverse short‐term outcome. Still, for most mediators, only nonsignificant variations in inflammatory responses were observed for groups of microbial aetiology, disease severity and short‐term outcome. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 7, 2017 Category: General Medicine Authors: William W. Siljan, Jan C. Holter, St åle H. Nymo, Einar Husebye, Thor Ueland, Pål Aukrust, Tom E. Mollnes, Lars Heggelund Tags: ORIGINAL ARTICLE Source Type: research

Decreased platelet inhibition by P2Y12 receptor blockers in anaemia
ConclusionAnaemia is associated with decreased platelet inhibition by ADP P2Y12 receptor antagonists after elective and acute percutaneous interventions with stent implantation. However, due to inconsistencies between different platelet function tests additional data are needed to clarify the role of anaemia for platelet inhibition. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 7, 2017 Category: General Medicine Authors: Patricia P. Wadowski, Christoph W. Kopp, Renate Koppensteiner, Irene M. Lang, Joseph Pultar, Silvia Lee, Constantin Weikert, Simon Panzer, Thomas Gremmel Tags: ORIGINAL ARTICLE Source Type: research

Angiotensin 1 ‐7 modulates electrophysiological characteristics and calcium homoeostasis in pulmonary veins cardiomyocytes via MAS/PI3K/eNOS signalling pathway
ConclusionAng‐(1‐7) regulates PV electrophysiological characteristics and Ca2+ homoeostasis via Mas/PI3K/eNOS signalling pathway. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 5, 2017 Category: General Medicine Authors: Yen ‐Yu Lu, Wen‐Shiann Wu, Yung‐Kuo Lin, Chen‐Chuan Cheng, Yao‐Chang Chen, Shih‐Ann Chen, Yi‐Jen Chen Tags: ORIGINAL ARTICLE Source Type: research

Commentary to “Patients not patents: drug research and development as a public enterprise”
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: Gerard Marshall Raj Tags: Commentary Source Type: research

The level of physical training modulates cytokine levels through P2X7 receptor in healthy subjects
ConclusionEND show higher P2X7R‐Infl expression and function vs SED and ATH; however, maximal exercise determines prevailing pro‐inflammatory vs anti‐inflammatory responses in untrained and trained participants, respectively, highlighting a likely cause‐effect relationship between degree of physical activity and P2X7R‐Infl‐mediated responses.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: Mario Comassi, Eleonora Santini, Chiara Rossi, Edoardo Vitolo, Marta Seghieri, Leonardo Tocchini, Ferdinando Franzoni, Anna Solini Tags: Original Paper Source Type: research

Response to the letter to the editor by Shadmani et  al – EJCI‐2017‐0437
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: Francesco Ursini Tags: Letter Source Type: research

Mitochondria and redox balance in celiac disease: a case control study
ConclusionsThese results highlight the mitochondrial involvement in CD and suggest the evaluation of the mtDNA content as a potential diagnostic and follow‐up parameter.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: A Picca, G Riezzo, A M S Lezza, C Clemente, V Pesce, A Orlando, G Chimienti, F Russo Tags: Original Paper Source Type: research

Hepcidin and DNA promoter methylation in hepatocellular carcinoma
ConclusionsThis study highlights a novel role for HAMP down‐regulation through DNA promoter hypermethylation and emphasizes the significance of epigenetics in the regulation of iron metabolism in HCC.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: Silvia Udali, Annalisa Castagna, Michela Corbella, Andrea Ruzzenente, Sara Moruzzi, Filippo Mazzi, Tommaso Campagnaro, Domenica De Santis, Antonia Franceschi, Patrizia Pattini, Rossella Gottardo, Oliviero Olivieri, Luigi Perbellini, Alfredo Guglielmi, San Tags: Original Paper Source Type: research

Evidence for increased chylomicron remnants in rheumatoid arthritis
ConclusionRA patients have higher levels of apo B48 compared to controls with high CVD risk and healthy controls, with normal levels of triglycerides. This accumulation of atherogenic chylomicron remnants may contribute to the elevated CVD risk in RA patients.This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: Benjamin Burggraaf, Deborah F van Breukelen ‐ van der Stoep, Jendé van Zeben, Noelle van der Meulen, Gert‐Jan M van de Geijn, Anho Liem, Pedro Valdivielso, José Rioja Villodres, José Ramírez‐Bollero, Ellen van der Zwan, Manuel Castro Cabezas Tags: Original Paper Source Type: research

Decision shaping neutrophil ‐platelet interplay in inflammation: From physiology to intervention
This article is protected by copyright. All rights reserved. (Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - December 1, 2017 Category: General Medicine Authors: Oliver Soehnlein Tags: Review Article Source Type: research

A translational evidence for cholesteryl ester transfer protein modulation by glucocorticoids: A time for reflection
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 30, 2017 Category: General Medicine Authors: Luca Liberale, Fabrizio Montecucco, Aldo Bonaventura Tags: COMMENTARY Source Type: research

Acknowledgement to Reviewers –2017
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 28, 2017 Category: General Medicine Tags: REVIEWER Source Type: research

Announcement
(Source: European Journal of Clinical Investigation)
Source: European Journal of Clinical Investigation - November 28, 2017 Category: General Medicine Tags: Announcement Source Type: research