Effects of Neonicotinoid Pesticide Exposure on Human Health: A Systematic Review
Conclusions: The studies conducted to date were limited in number with suggestive but methodologically weak findings related to chronic exposure. Given the wide-scale use of neonics, more studies are needed to fully understand their effects on human health. Citation: Cimino AM, Boyles AL, Thayer KA, Perry MJ. 2017. Effects of neonicotinoid pesticide exposure on human health: a systematic review. Environ Health Perspect 125:155–162; http://dx.doi.org/10.1289/EHP515 Address correspondence to M.J. Perry, Department of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington Univer...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Reviews February 2017 Source Type: research

Low-Dose Mixture Hypothesis of Carcinogenesis Workshop: Scientific Underpinnings and Research Recommendations
Conclusions: The theoretical merits of the low-dose carcinogenesis hypothesis are well founded with clear biological relevance, and therefore, the premise warrants further investigation. Expert recommendations include the need for better insights into the ways in which noncarcinogenic constituents might combine to uniquely affect the process of cellular transformation (in vitro) and environmental carcinogenesis (in vivo), including investigations of the role of key defense mechanisms in maintaining transformed cells in a dormant state. The scientific community will need to acknowledge limitations of animal-based models in ...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Reviews February 2017 Source Type: research

The Prevalence and Use of Walking Loops in Neighborhood Parks: A National Study
Conclusions: Walking loops may be a promising means of increasing population level physical activity. Further studies are needed to confirm a causal relationship. Citation: Cohen DA, Han B, Evenson KR, Nagel C, McKenzie TL, Marsh T, Williamson S, Harnik P. 2017. The prevalence and use of walking loops in neighborhood parks: a national study. Environ Health Perspect 125:170–174; http://dx.doi.org/10.1289/EHP293 Address correspondence to D.A. Cohen, RAND Corporation, 1776 Main St., Santa Monica, CA 90407 USA. Telephone: (310) 393-0411, ext 6023. E-mail: dcohen@rand.org This study was funded by the National Heart, Lung, a...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Cardiovascular Benefits of Wearing Particulate-Filtering Respirators: A Randomized Crossover Trial
Conclusions: Short-term wearing of particulate-filtering respirators may produce cardiovascular benefits by improving autonomic nervous function and reducing BP. Citation: Shi J, Lin Z, Chen R, Wang C, Yang C, Cai J, Lin J, Xu X, Ross JA, Zhao Z, Kan H. 2017. Cardiovascular benefits of wearing particulate-filtering respirators: a randomized crossover trial. Environ Health Perspect 125:175–180; http://dx.doi.org/10.1289/EHP73 Address correspondence to H. Kan, Department of Environmental Health, School of Public Health, Fudan University, P.O. Box 249, 130 Dong-An Rd., Shanghai 200032, China. Telephone: 86 (21) 5423 7908....
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Evaluating the Impact of the U.S. National Toxicology Program: A Case Study on Hexavalent Chromium
Conclusions: This study identified a broad and objective approach for assessing NTP’s effectiveness, including methodological needs for more thorough and efficient impact assessments in the future. Citation: Xie Y, Holmgren S, Andrews DMK, Wolfe MS. 2017. Evaluating the impact of the U.S. National Toxicology Program: a case study on hexavalent chromium. Environ Health Perspect 125:181–188; http://dx.doi.org/10.1289/EHP21 Address correspondence to Y. Xie, National Institute of Environmental Health Sciences, P.O. Box 12233, Mail Drop K2-03, Research Triangle Park, NC 27709 USA. Express mail address: 530 Davis Dr., Room...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Associations between Unconventional Natural Gas Development and Nasal and Sinus, Migraine Headache, and Fatigue Symptoms in Pennsylvania
Conclusions: This study provides evidence that UNGD is associated with nasal and sinus, migraine headache, and fatigue symptoms in a general population representative sample. Citation: Tustin AW, Hirsch AG, Rasmussen SG, Casey JA, Bandeen-Roche K, Schwartz BS. 2017. Associations between unconventional natural gas development and nasal and sinus, migraine headache, and fatigue symptoms in Pennsylvania. Environ Health Perspect 125:189–197; http://dx.doi.org/10.1289/EHP281 Address correspondence to B.S. Schwartz, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Room W7041, Baltimore, MD 21205 USA. Teleph...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Sex-Specific Effects of Organophosphate Diazinon on the Gut Microbiome and Its Metabolic Functions
Conclusions: Diazinon exposure perturbed the gut microbiome community structure, functional metagenome, and associated metabolic profiles in a sex-specific manner. These findings may provide novel insights regarding perturbations of the gut microbiome and its functions as a potential new mechanism contributing to diazinon neurotoxicity and, in particular, its sex-selective effects. Citation: Gao B, Bian X, Mahbub R, Lu K. 2017. Sex-specific effects of organophosphate diazinon on the gut microbiome and its metabolic functions. Environ Health Perspect 125:198–206; http://dx.doi.org/10.1289/EHP202 Address correspondence t...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies
Conclusions: Using a pathway-based selection process, we identified novel genes potentially involved in adult asthma by interaction with occupational exposure. These genes play a role in the NF-κB pathway, which is involved in inflammation. Citation: Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, Dizier MH, Dumas O, Gonzalez JR, Imboden M, Mehta AJ, Tubert-Bitter P, Zock JP, Jarvis D, Probst-Hensch NM, Demenais F, Nadif R. 2017. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies. Environ Health Perspect 125:207–2...
Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research

Erratum: “Para– and Ortho-Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity”
About This Article open Citation: Kim KH, Bose DD, Ghogha A, Riehl J, Zhang R, Barnhart CD, Lein PJ, Pessah IN. 2012. Erratum: “Para– and Ortho-Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity.” Environ Health Perspect 120:A189; http://dx.doi.org/10.1289/ehp.120-A189 Final Publication: 1 May 2012   Related EHP Article Para– and Ortho-Substitutions Are Key Determinants of Polybrominated Diphenyl Ether Activity toward Ryanodine Receptors and Neurotoxicity Kyung Ho Kim, Diptiman D. Bose, Atefeh Ghogha, Joyce Riehl, Rui Zhang, Chri...
Source: EHP Research - January 23, 2017 Category: Environmental Health Authors: Sam Duvall Tags: Perspectives Erratum May 2012 Source Type: research

Errata: “Temporal Variability of Tungsten and Cobalt in Fallon, Nevada” & “A Retrospective Assessment of Occupational Exposure to Elemental Carbon in the U.S. Trucking Industry”
Discussion”), there was a coding error in the original calculation: The percentage of person-years prior to 1971 was 8% and not 1.1%, as stated in the article. The authors apologize for the error. This error has been corrected in the PDF version of this article. (Source: EHP Research)
Source: EHP Research - January 23, 2017 Category: Environmental Health Authors: Sam Duvall Tags: Perspectives Erratum February 2012 Source Type: research

Erratum: “A Retrospective Assessment of Occupational Exposure to Elemental Carbon in the U.S. Trucking Industry”
Discussion”), there was a coding error in the original calculation: The percentage of person-years prior to 1971 was 8% and not 1.1%, as stated in the article. The authors apologize for the error. This error has been corrected in the PDF version of this article. (Source: EHP Research)
Source: EHP Research - January 23, 2017 Category: Environmental Health Authors: Sam Duvall Tags: Perspectives Erratum February 2012 Source Type: research

Colorectal Cancer and Long-Term Exposure to Trihalomethanes in Drinking Water: A Multicenter Case –Control Study in Spain and Italy
Conclusions: We did not find clear evidence of an association between detailed estimates of lifetime total THM exposure and colorectal cancer in our large case–control study population. Negative associations with chloroform concentrations and ingestion suggest differences among specific THMs, but these findings should be confirmed in other study populations. Citation: Villanueva CM, Gracia-Lavedan E, Bosetti C, Righi E, Molina AJ, Martín V, Boldo E, Aragonés N, Perez-Gomez B, Pollan M, Gomez Acebo I, Altzibar JM, Jiménez Zabala A, Ardanaz E, Peiró R, Tardón A, Chirlaque MD, Tavani A, Polesel J, Serraino D, Pisa F,...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice
Conclusion: In utero exposure to environmental mutagens contributes to somatic and germline mosaicism, permanently affecting both the genetic health of the F1 and the population gene pool. Citation: Meier MJ, O’Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. 2017. In utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice. Environ Health Perspect 125:82–88; http://dx.doi.org/10.1289/EHP211 *These authors contributed equally to this work. Address correspondence to F. Marchetti, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, ...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

Urban and Transport Planning Related Exposures and Mortality: A Health Impact Assessment for Cities
Conclusions: PA factors and environmental exposures can be modified by changes in urban and transport planning. We emphasize the need for a) the reduction of motorized traffic through the promotion of active and public transport and b) the provision of green infrastructure, both of which are suggested to provide opportunities for PA and for mitigation of air pollution, noise, and heat. Citation: Mueller N, Rojas-Rueda D, Basagaña X, Cirach M, Cole-Hunter T, Dadvand P, Donaire-Gonzalez D, Foraster M, Gascon M, Martinez D, Tonne C, Triguero-Mas M, Valentín A, Nieuwenhuijsen M. 2017. Urban and transport planning rela...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

Delineation of Spatial Variability in the Temperature –Mortality Relationship on Extremely Hot Days in Greater Vancouver, Canada
Conclusions: Our methods provide a data-driven framework for spatial delineation of the temperature–mortality relationship by heat exposure and social vulnerability. The results can be used to map and target the most vulnerable areas for public health intervention. Citation: Ho HC, Knudby A, Walker BB, Henderson SB. 2017. Delineation of spatial variability in the temperature–mortality relationship on extremely hot days in greater Vancouver, Canada. Environ Health Perspect 125:66–75; http://dx.doi.org/10.1289/EHP224 Address correspondence to H.C. Ho, Institute of Environment, Energy and Sustainability, Chinese Unive...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research