Genes Interacting with Occupational Exposures to Low Molecular Weight Agents and Irritants on Adult-Onset Asthma in Three European Studies

Conclusions: Using a pathway-based selection process, we identified novel genes potentially involved in adult asthma by interaction with occupational exposure. These genes play a role in the NF-κB pathway, which is involved in inflammation.

Citation: Rava M, Ahmed I, Kogevinas M, Le Moual N, Bouzigon E, Curjuric I, Dizier MH, Dumas O, Gonzalez JR, Imboden M, Mehta AJ, Tubert-Bitter P, Zock JP, Jarvis D, Probst-Hensch NM, Demenais F, Nadif R. 2017. Genes interacting with occupational exposures to low molecular weight agents and irritants on adult-onset asthma in three European studies. Environ Health Perspect 125:207–214; http://dx.doi.org/10.1289/EHP376
*These authors contributed equally to this work, #these authors contributed equally to this work, and †these authors contributed equally to this work.
Address correspondence to R. Nadif, Inserm UMR-S 1168, VIMA: Aging and chronic diseases, Epidemiological and Public Health Approaches, 16, avenue Paul Vaillant Couturier, F-94807, Villejuif, France. Telephone: [phone]. E-mail: [e-mail]
We thank all study members and staff involved in data collections in each cohort. For a complete list of contributors and details regarding funding, please see the Appendix.
Glaxo Wellcome and Glaxo France, producers of asthma medication, partially funded the local studies (Bergen and Paris, respectively) in ECHRS II. The authors declare they have no other actual or potential competing financial interes...

Source: EHP Research - February 1, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles February 2017 Source Type: research