In Utero Exposure to Benzo[a]Pyrene Increases Mutation Burden in the Soma and Sperm of Adult Mice

Conclusion: In utero exposure to environmental mutagens contributes to somatic and germline mosaicism, permanently affecting both the genetic health of the F1 and the population gene pool.

Citation: Meier MJ, O’Brien JM, Beal MA, Allan B, Yauk CL, Marchetti F. 2017. In utero exposure to benzo[a]pyrene increases mutation burden in the soma and sperm of adult mice. Environ Health Perspect 125:82–88; http://dx.doi.org/10.1289/EHP211
*These authors contributed equally to this work.
Address correspondence to F. Marchetti, Environmental Health Science and Research Bureau, Health Canada, 50 Colombine Driveway, Ottawa, Ontario, K1A 0K9, Canada. Telephone: [phone]. E-mail: [e-mail]
Currrent address for J.M.O.: Ecotoxicology and Wildlife Health Division, Environment Canada, Ottawa, ON, Canada.
We acknowledge technical assistance from M. Rosales, J. Gingerich, and L. Soper. We are thankful for comments received from D. Desaulniers and M. Wade.
This work was supported by Health Canada intramural funding. Stipend support to M.J.M., M.A.B., and J.M.O. was provided by the Natural Sciences and Engineering Research Council of Canada and by the Canadian Institutes of Health Research (CIHR) Training Program in Reproduction, Early Development, and the Impact on Health.
The authors declare they have no actual or potential competing financial interests.
Received: 23 March 2016
Revised: 13 June 2016
Accepted: 23 June 2016
Published: 22 July 201...

Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research