A Global Learning with Local Preservation Method for Microarray Data Imputation
In this study, we propose a Global Learning with Local Preservation method (GL2P) for imputation of missing values in microarray data. GL2P consists of two components: a local similarity measurement module and a global weighted imputation module. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - August 4, 2016 Category: Bioinformatics Authors: Ye Chen, Aiguo Wang, Huitong Ding, Xia Que, Yabo Li, Ning An, Lili Jiang Source Type: research
Identification of Informative Genes and Pathways using an Improved Penalized Support Vector Machine with a Weighting Scheme
Incorporation of pathway knowledge into microarray analysis has brought better biological interpretation of the analysis outcome. However, most pathway data are manually curated without specific biological context. Non-informative genes could be included when the pathway data is used for analysis of context specific data like cancer microarray data. Therefore, efficient identification of informative genes is inevitable. Embedded methods like penalized classifiers have been used for microarray analysis due to their embedded gene selection. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - August 3, 2016 Category: Bioinformatics Authors: Weng Howe Chan, Mohd Saberi Mohamad, Safaai Deris, Nazar Zaki, Shahreen Kasim, Sigeru Omatu, Juan Manuel Corchado, Hany Al Ashwal Source Type: research
Effects of Lumbar Drainage on CSF Dynamics in Subarachnoid Hemorrhage Condition: A Computational Study
In this study, a subject-specific three dimensional model of the cerebrospinal fluid (CSF) pathways and compartments was developed. The ventricular and the cranial and spinal subarachnoid spaces were reconstructed using magnetic resonance images. Occurrence of subarachnoid hemorrhage was modeled. Since the presence of blood in the CSF spaces is known to be the cause of complications such as cerebral vasospasm, concentration of blood in these spaces was investigated. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - August 2, 2016 Category: Bioinformatics Authors: Ehsan Abolfazli, Nasser Fatouraee, Amir Saeed Seddighi Source Type: research
Tailor-made shaping of microcatheters using three-dimensional printed vessel models for endovascular coil embolization
Stabilization of microcatheters during coiling after their optimal shaping are key factors for successful endovascular coil embolization of cerebral aneurysms. However, stabilization and optimal shaping of microcatheters are sometimes difficult. Our aim was to introduce “tailor-made” microcatheter shapes for coil embolization using three-dimensional (3D) printed vessel models. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - August 1, 2016 Category: Bioinformatics Authors: Toshihiro Ishibashi, Hiroyuki Takao, Takashi Suzuki, Ichiro Yuki, Shogo Kaku, Issei Kan, Kengo Nishimura, Tomoaki Suzuki, Mitsuyosi Watanabe, Kostadin Karagiozov, Yuichi Murayama Source Type: research
Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity
In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - August 1, 2016 Category: Bioinformatics Authors: Xuwen Tong, Jingliang Dong, Yidan Shang, Kiao Inthavong, Jiyuan Tu Source Type: research
An automated string-based approach to extracting and characterizing White Matter fiber-bundles
In this paper, we propose an automated approach to extracting White Matter (WM) fiber-bundles through clustering and model characterization. The key novelties of our approach are: a new string-based formalism, allowing an alternative representation of WM fibers, a new string dissimilarity metric, a WM fiber clustering technique, and a new model-based characterization algorithm. Thanks to these novelties, the complex problem of WM fiber-bundle extraction and characterization reduces to a much simpler and well-known string extraction and analysis problem. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 29, 2016 Category: Bioinformatics Authors: Francesco Cauteruccio, Claudio Stamile, Giorgio Terracina, Domenico Ursino, Dominique Sappey-Marinier Source Type: research
Estimation of Salient Regions Related to Chronic Gastritis Using Gastric X-ray Images
Since technical knowledge and a high degree of experience are necessary for diagnosis of chronic gastritis, computer-aided diagnosis (CAD) systems that analyze gastric X-ray images are desirable in the field of medicine. Therefore, a new method that estimates salient regions related to chronic gastritis/non-gastritis for supporting diagnosis is presented in this paper. In order to estimate salient regions related to chronic gastritis/non-gastritis, the proposed method monitors the distance between a target image feature and Support Vector Machine (SVM)-based hyperplane for its classification. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 26, 2016 Category: Bioinformatics Authors: Ren Togo, Kenta Ishihara, Takahiro Ogawa, Miki Haseyama Source Type: research
Fusion of sparse representation and dictionary matching for identifications of humans in uncontrolled environment
Biomechanics based human identification is a major area of research. Biomechanics based approaches depend on accurately recognizing humans using body movements, the accuracy of these approaches are enhanced by incorporating the knee-hip angle to angle relationships. Current biomechanics based models are developed by considering the biomechanics of human walking and running. In biomechanics the joint angle characteristics, also known as gait features plays a vital role in identification of humans. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 19, 2016 Category: Bioinformatics Authors: Steven Lawrence Fernandes, G. Josemin Bala Source Type: research
Pain buddy: A novel use of m-health in the management of children's cancer pain
Over 12,000 children are diagnosed with cancer every year in the United States. In addition to symptoms associated with their disease, children undergoing chemotherapy frequently experience significant pain, which is unfortunately often undertreated. The field of m-Health offers an innovative avenue for pain assessment and intervention in the home setting. The current study describes the development and initial evaluation of a tablet-based program, Pain Buddy, aimed to enhance pain management and foster improved quality of life in children ages 8 to 18 years undergoing cancer treatment. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 19, 2016 Category: Bioinformatics Authors: Michelle A. Fortier, Winnie W. Chung, Ariana Martinez, Sergio Gago-Masague, Leonard Sender Source Type: research
Proximal femoral growth plate mechanical behavior: Comparison between different developmental stages
In long bones the growth plate is a cartilaginous structure located between the epiphysis and the diaphysis. This structure regulates longitudinal growth and helps determine the structure of mature bone through the process of endochondral ossification. During human growth the femur's proximal growth plate experiences changes in its morphology that may be related to its mechanical environment. Thus, in order to test this hypothesis from a computational perspective, a finite element analysis on a proximal femur was performed on which we modeled different physeal geometries corresponding to the shapes acquired for this struct...
Source: Computers in Biology and Medicine - July 19, 2016 Category: Bioinformatics Authors: H éctor Alfonso Castro-Abril, María Lucía Gutiérrez, Diego Alexander Garzón-Alvarado Source Type: research
Fusion of sparse representation and dictionary matching for identifications of humans in uncontrolled environment
Biomechanics based human identification is a major area of research. Biomechanics based approaches depend on accurately recognizing humans using body movements, the accuracy of these approaches are enhanced by incorporating the knee-hip angle to angle relationships. Current biomechanics based models are developed by considering the biomechanics of human walking and running. In biomechanics the joint angle characteristics, also known as gait features plays a vital role in identification of humans. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 19, 2016 Category: Bioinformatics Authors: Steven Lawrence Fernandes, G. Josemin Bala Source Type: research
Pain buddy: A novel use of m-health in the management of children's cancer pain
Over 12,000 children are diagnosed with cancer every year in the United States. In addition to symptoms associated with their disease, children undergoing chemotherapy frequently experience significant pain, which is unfortunately often undertreated. The field of m-Health offers an innovative avenue for pain assessment and intervention in the home setting. The current study describes the development and initial evaluation of a tablet-based program, Pain Buddy, aimed to enhance pain management and foster improved quality of life in children ages 8 to 18 years undergoing cancer treatment. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 19, 2016 Category: Bioinformatics Authors: Michelle A. Fortier, Winnie W. Chung, Ariana Martinez, Sergio Gago-Masague, Leonard Sender Source Type: research
Proximal femoral growth plate mechanical behavior: Comparison between different developmental stages
In long bones the growth plate is a cartilaginous structure located between the epiphysis and the diaphysis. This structure regulates longitudinal growth and helps determine the structure of mature bone through the process of endochondral ossification. During human growth the femur's proximal growth plate experiences changes in its morphology that may be related to its mechanical environment. Thus, in order to test this hypothesis from a computational perspective, a finite element analysis on a proximal femur was performed on which we modeled different physeal geometries corresponding to the shapes acquired for this struct...
Source: Computers in Biology and Medicine - July 19, 2016 Category: Bioinformatics Authors: Héctor Alfonso Castro-Abril, María Lucía Gutiérrez, Diego Alexander Garzón-Alvarado Source Type: research
Cancerome: A hidden informative subnetwork of the diseasome
In this study, we first constructed an integrated human disease network based on nine different biological aspects, including molecular, functional, and clinical features. (Source: Computers in Biology and Medicine)
Source: Computers in Biology and Medicine - July 18, 2016 Category: Bioinformatics Authors: Mahdi Jalili, Ali Salehzadeh-Yazdi, Marjan Yaghmaie, Ardeshir Ghavamzadeh, Kamran Alimoghaddam Source Type: research
