Effects of nasal drug delivery device and its orientation on sprayed particle deposition in a realistic human nasal cavity

In this study, the effects of nasal drug delivery device and the spray nozzle orientation on sprayed droplets deposition in a realistic human nasal cavity were numerically studied. Prior to performing the numerical investigation, an in-house designed automated actuation system representing mean adults actuation force was developed to produce realistic spray plume. Then, the spray plume development was filmed by high speed photography system, and spray characteristics such as spray cone angle, break-up length, and average droplet velocity were obtained through off-line image analysis.
Source: Computers in Biology and Medicine - Category: Bioinformatics Authors: Source Type: research