Clinical Microbiology and Infection This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Abstracts of Online‐Only Research Notes
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Tags: Abstracts of Online‐Only Research Notes Source Type: research

Abstracts of Online‐Only Original Articles
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Tags: Abstracts of Online‐Only Original Articles Source Type: research

Coordinating the clinical management of imported human cases suspected of being infected with a highly pathogenic virus such as Ebola
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Authors: X. Lamballerie Tags: Infection Hot Topic Source Type: research

Hepatitis C virus treatment revolution: need for close monitoring
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Authors: G. Ippolito, G. Antonelli, M. R. Capobianchi, S. Lanini Tags: Infection Hot Topic Source Type: research

Abstracts of Online‐Only Infection Hot Topics
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Tags: Abstracts of Online‐Only Infection Hot Topics Source Type: research

Faecal microbiota transplantation: from practice to legislation before considering industrialization
Abstract Recurrent Clostridium difficile infections constitute an important medical concern. Evidence has been provided showing that faecal microbiota transplantation is a more efficient treatment than antibiotics. Serious side effects are unusual, and acceptability is not an obstacle. Nevertheless, protocols are heterogeneous with respect to the selection of donors and the methodology used for the faecal transplantation. Regulations by both the Food and Drug Administration and the French authorities consider stool samples to be drugs, and suggest strict supervision in clinical trials. Donor screening by questionnaire or b...
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Authors: J.‐C. Lagier Tags: Review Source Type: research

Faecal microbiota transplantation—the Austrian approach
Abstract The intestinal microbiome is essential for maintaining human health and defending against intestinal pathogens. Alterations of the intestinal microbiota, also termed dysbiosis, play a pivotal role in the pathogenesis of various human diseases. Faecal microbiota transplantation (FMT) is aimed at correcting these alterations by delivering faecal microorganisms from a healthy person to the intestines of a patient. At present, recurrent Clostridium difficile infection is the only indication supported by solid scientific evidence, but many ongoing studies are investigating FMT in other dysbiosis‐related diseases, suc...
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Authors: P. K. Kump, R. Krause, F. Allerberger, C. Högenauer Tags: Review Source Type: research

Practical implementation of faecal transplantation
Abstract Clostridium difficile infection is a leading cause of antibiotic‐related and healthcare‐related diarrhoea. In the past decade, faecal microbiota transplantation or transfer has attracted increasing interest as an effective treatment strategy for severe recurrent C. difficile infection, with a global success rate of >80%. However, experience with this procedure is limited by a lack of randomized trials supporting its efficacy and the lack of standardization of the procedure. This review will address the practical aspects of the protocol. (Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Authors: N. Kapel, M. Thomas, O. Corcos, C. Mayeur, L. Barbot‐Trystram, Y. Bouhnik, F. Joly Tags: Review Source Type: research

Faecal transplantation and infectious diseases practitioners
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 15, 2014 Category: Microbiology Authors: D. Raoult Tags: Editorial Source Type: research

Early carbapenem ‐resistant Klebsiella pneumoniae bacteraemia: should we expand the screening?
(Source: Clinical Microbiology and Infection)
Source: Clinical Microbiology and Infection - December 13, 2014 Category: Microbiology Authors: D. R. Giacobbe, V. Del Bono, A. Marchese, C. Viscoli Tags: Letter Source Type: research

Hepatitis C virus and interferon type III (interferon‐λ3/interleukin‐28B and interferon‐λ4): genetic basis of susceptibility to infection and response to antiviral treatment
Abstract There has been a significant increase in our understanding of the host genetic determinants of susceptibility to viral infections in recent years. Recently, two single‐nucleotide polymorphisms (SNPs), rs12979860 T/C and rs8099917 T/G, upstream of the interleukin (IL)‐28B/interferon (IFN)‐λ3 gene have been clearly associated with spontaneous and treatment‐induced viral clearance in hepatitis C virus (HCV) infection. Because of their power in predicting the response to IFN/ribavirin therapy, the above SNPs have been used as a diagnostic tool, even though their relevance in the management of HCV infection w...
Source: Clinical Microbiology and Infection - December 12, 2014 Category: Microbiology Authors: E. Riva, C. Scagnolari, O. Turriziani, G. Antonelli Tags: Review Source Type: research

Matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry: revolutionizing clinical laboratory diagnosis of mould infections
Abstract The clinical diagnosis of mould infections currently involves complex species identification based on morphological criteria, which is often prone to error. Employing an extensive mould species reference spectral library (up to 2832 reference spectra, corresponding to 708 strains from 347 species), we assessed the extent to which matrix‐assisted laser desorption ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) enhanced the accuracy of species identification. MALDI‐TOF MS data were validated against morphology‐based and DNA sequence‐based results with 262 clinical isolates collected over a...
Source: Clinical Microbiology and Infection - December 12, 2014 Category: Microbiology Authors: M. Gautier, S. Ranque, A.‐C. Normand, P. Becker, A. Packeu, C. Cassagne, C. L'Ollivier, M. Hendrickx, R. Piarroux Tags: Original Article Source Type: research

Predicting pneumococcal community‐acquired pneumonia in the emergency department
Abstract The aim of this study was to quantify the value of clinical predictors available in the emergency department (ED) in predicting Streptococcus pneumoniae as the cause of community‐acquired pneumonia (CAP). A prospective, observational, cohort study of patients with CAP presenting in the ED was performed. Pneumococcal aetiology of CAP was based on either bacteraemia, or S. pneumoniae being cultured from sputum, or urinary immunochromatographic assay positivity, or positivity of a novel serotype‐specific urinary antigen detection test. Multivariate logistic regression was used to identify independent predictors ...
Source: Clinical Microbiology and Infection - December 12, 2014 Category: Microbiology Authors: S. M. Huijts, W. G. Boersma, D. E. Grobbee, W. C. Gruber, K. U. Jansen, J. A. J. W. Kluytmans, B. A. F. Kuipers, F. Palmen, M. W. Pride, C. Webber, M. J. M. Bonten, Tags: Original Article Source Type: research

A simple, robust and rapid approach to detect carbapenemases in Gram‐negative isolates by MALDI‐TOF mass spectrometry: validation with triple quadripole tandem mass spectrometry, microarray and PCR
Abstract Carbapenemases should be accurately and rapidly detected, given their possible epidemiological spread and their impact on treatment options. Here, we developed a simple, easy and rapid matrix‐assisted laser desorption ionization‐time of flight (MALDI‐TOF)‐based assay to detect carbapenemases and compared this innovative test with four other diagnostic approaches on 47 clinical isolates. Tandem mass spectrometry (MS‐MS) was also used to determine accurately the amount of antibiotic present in the supernatant after 1 h of incubation and both MALDI‐TOF and MS‐MS approaches exhibited a 100% sensitivity ...
Source: Clinical Microbiology and Infection - December 12, 2014 Category: Microbiology Authors: C. Vogne, G. Prod'hom, K. Jaton, L. A. Decosterd, G. Greub Tags: Original Article Source Type: research