EWS-FLI1 Retargets BAF Chromatin Remodeling Complexes in Ewing Sarcoma [Ewing Sarcoma]
BAF recruitment to GGAA microsatellites activates the Ewing sarcoma transcriptional program. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Ewing Sarcoma Source Type: research
Ascorbate Depletion Reduces TET2 Activity to Accelerate Leukemogenesis [Leukemia]
Elevated ascorbate levels maintain TET2 activity in HSCs and decline with differentiation. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Leukemia Source Type: research
Local Delivery of IFN{alpha} Has Antitumor Activity in Bladder Cancer [Clinical Trials]
Intravesical delivery of rAd-IFNα/Syn3 is safe and achieves durable responses in high-grade NMIBC. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Clinical Trials Source Type: research
PON2 Promotes Glucose Uptake to Support PDAC Growth and Metastasis [Pancreatic Cancer]
PON2 promotes GLUT1-mediated glucose transport, is upregulated in PDAC, and is required for PDAC growth. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Pancreatic Cancer Source Type: research
TERT Promoter Mutations Promote Immortalization and Genomic Instability [Telomerase]
TERT promoter mutations may induce early and late tumorigenesis by separate mechanisms. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Telomerase Source Type: research
TMPRSS2-ERG Alters the cis-Regulatory Landscape and Activates NOTCH [Prostate Cancer]
In TMPRSS2–ERG-positive prostate tumors, ERG establishes new clusters of regulatory elements (CORE). (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Prostate Cancer Source Type: research
LMO1 Cooperates with MYCN to Promote Neuroblastomagenesis and Metastasis [Neuroblastoma]
Transgenic expression of LMO1 promotes neuroblastoma metastasis in a MYCN-driven zebrafish model. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: Neuroblastoma Source Type: research
Noted [News in Brief]
A collection of recently published news items. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Resistance Genes Identified [News in Brief]
A CRISPR-based screen of all 19,050 genes in the genome has revealed around 100 genes that cancer cells must express in order for T cells—and, thus, immunotherapies—to effectively recognize and kill tumors. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Gilead Buying Kite for $11.9 Billion [News in Brief]
Gilead Sciences will buy Kite Pharma—and its autologous CAR T-cell technology—for $11.9 billion. The acquisition will help Gilead build its oncology portfolio and boost its revenues. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
ADC Approval Likely to Spur More Research [News in Brief]
The FDA's decision to approve inotuzumab ozogamicin for patients with relapsed or refractory acute lymphoblastic leukemia could open up further uses for the drug. It is being tested as a first-line treatment in combination with chemotherapy. The decision could also stimulate research into other antibody–drug conjugates. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Pediatric MATCH Trial Opens Enrollment [News in Brief]
The largest basket study to date of targeted agents in children and adolescents began enrolling patients in late July. Pediatric MATCH will study seven drugs to start; researchers plan to add at least two more in the near future. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Surrogate Endpoint ID'd for Prostate Cancer Trials [News in Brief]
Metastasis-free survival is a strong surrogate for overall survival for men with localized prostate cancer, a meta-analysis shows. The intermediate outcome measure could help accelerate the evaluation of novel adjuvant therapies in this patient population. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Lasker Awards Honor Three Researchers [News in Brief]
Three top cancer researchers were among recipients of the prestigious Albert and Mary Lasker Foundation awards. Douglas R. Lowy, MD, and John T. Schiller, PhD, were honored for research leading to the development of the first human papillomavirus vaccine. The prize for basic medical research went to Michael N. Hall, PhD, who discovered the TOR signaling pathway and its role in regulating cell growth and metabolism. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
CDK4/6 Inhibitors Induce Antitumor Immunity [News in Brief]
CDK4/6 inhibitors not only induce cell-cycle arrest but also promote antitumor immunity by stimulating the production of type III interferons, which enhance tumor antigen presentation, and suppress regulatory T cells. The immune effects of these drugs provide a rationale for combining CDK4/6 inhibitors with checkpoint blockade agents. (Source: Cancer Discovery)
Source: Cancer Discovery - October 2, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
