The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function [Research Articles]
This article is highlighted in the In This Issue feature, p. 339 (Source: Cancer Discovery)
Source: Cancer Discovery - April 2, 2017 Category: Cancer & Oncology Authors: Wan, L., Chen, M., Cao, J., Dai, X., Yin, Q., Zhang, J., Song, S.-J., Lu, Y., Liu, J., Inuzuka, H., Katon, J. M., Berry, K., Fung, J., Ng, C., Liu, P., Song, M. S., Xue, L., Bronson, R. T., Kirschner, M. W., Cui, R., Pandolfi, P. P., Wei, W. Tags: Research Articles Source Type: research
Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer [Research Articles]
This study creates a validated resource of inherited variants that govern where and how cancer develops, opening avenues for prevention research.
Significance: This study systematically identifies germline variants that directly affect tumor evolution, either by dramatically increasing alteration frequency of specific cancer genes or by influencing the site where a tumor develops. Cancer Discovery; 7(4); 410–23. ©2017 AACR.
See related commentary by Geeleher and Huang, p. 354.
This article is highlighted in the In This Issue feature, p. 339 (Source: Cancer Discovery)
Source: Cancer Discovery - April 2, 2017 Category: Cancer & Oncology Authors: Carter, H., Marty, R., Hofree, M., Gross, A. M., Jensen, J., Fisch, K. M., Wu, X., DeBoever, C., Van Nostrand, E. L., Song, Y., Wheeler, E., Kreisberg, J. F., Lippman, S. M., Yeo, G. W., Gutkind, J. S., Ideker, T. Tags: Research Articles Source Type: research
Safety and Antitumor Activity of the Multitargeted Pan-TRK, ROS1, and ALK Inhibitor Entrectinib: Combined Results from Two Phase I Trials (ALKA-372-001 and STARTRK-1) [Research Articles]
This article is highlighted in the In This Issue feature, p. 339 (Source: Cancer Discovery)
Source: Cancer Discovery - April 2, 2017 Category: Cancer & Oncology Authors: Drilon, A., Siena, S., Ou, S.-H. I., Patel, M., Ahn, M. J., Lee, J., Bauer, T. M., Farago, A. F., Wheler, J. J., Liu, S. V., Doebele, R., Giannetta, L., Cerea, G., Marrapese, G., Schirru, M., Amatu, A., Bencardino, K., Palmeri, L., Sartore-Bianchi, A., Va Tags: Research Articles Source Type: research
Adaptive Reprogramming of De Novo Pyrimidine Synthesis Is a Metabolic Vulnerability in Triple-Negative Breast Cancer [Research Briefs]
This article is highlighted in the In This Issue feature, p. 339 (Source: Cancer Discovery)
Source: Cancer Discovery - April 2, 2017 Category: Cancer & Oncology Authors: Brown, K. K., Spinelli, J. B., Asara, J. M., Toker, A. Tags: Research Briefs Source Type: research
PTEN Regulates Glutamine Flux to Pyrimidine Synthesis and Sensitivity to Dihydroorotate Dehydrogenase Inhibition [Research Briefs]
This article is highlighted in the In This Issue feature, p. 339 (Source: Cancer Discovery)
Source: Cancer Discovery - April 2, 2017 Category: Cancer & Oncology Authors: Mathur, D., Stratikopoulos, E., Ozturk, S., Steinbach, N., Pegno, S., Schoenfeld, S., Yong, R., Murty, V. V., Asara, J. M., Cantley, L. C., Parsons, R. Tags: Research Briefs Source Type: research
