CD4+ T-cell Depletion Prevents GVHD [News in Brief]
Temporary removal of CD4+ T cells after an allogeneic hematopoietic stem-cell transplant leads to changes in the nature of CD8+ T cells that, according to a mouse study, help prevent graft-versus-host disease without jeopardizing the therapy's potential to eliminate leukemia or lymphoma. (Source: Cancer Discovery)
Source: Cancer Discovery - June 1, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Drug Blocks Synaptic Hijacking in Gliomas [News in Brief]
An enzyme called ADAM10 cleaves a protein found in synaptic membranes, creating a soluble factor that can fuel the growth of brain tumors. Blocking this enzyme shrinks tumors in xenograft models of pediatric glioblastoma and diffuse intrinsic pontine glioma, two brain cancers with few to no effective drug options, researchers reported at the American Academy of Neurology 2017 Annual Meeting. (Source: Cancer Discovery)
Source: Cancer Discovery - June 1, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Three Cancer Researchers Win CZ Biohub Prizes [News in Brief]
Three cancer researchers are among the first of 47 investigators to receive 5 years of funding through the Chan Zuckerberg Biohub. The financial awards, granted to scientists at the Biohub's three member institutions, will support early stage, high-risk foundational work at the intersection of biology and engineering. (Source: Cancer Discovery)
Source: Cancer Discovery - June 1, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE2-Mediated Suppression of Antitumor Immunity [Research Articles]
This article is highlighted in the In This Issue feature, p. 443 (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Loo, T. M., Kamachi, F., Watanabe, Y., Yoshimoto, S., Kanda, H., Arai, Y., Nakajima-Takagi, Y., Iwama, A., Koga, T., Sugimoto, Y., Ozawa, T., Nakamura, M., Kumagai, M., Watashi, K., Taketo, M. M., Aoki, T., Narumiya, S., Oshima, M., Arita, M., Hara, E., O Tags: Research Articles Source Type: research
BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells [Research Articles]
This article is highlighted in the In This Issue feature, p. 443 (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Valls, E., Lobry, C., Geng, H., Wang, L., Cardenas, M., Rivas, M., Cerchietti, L., Oh, P., Yang, S. N., Oswald, E., Graham, C. W., Jiang, Y., Hatzi, K., Agirre, X., Perkey, E., Li, Z., Tam, W., Bhatt, K., Leonard, J. P., Zweidler-McKay, P. A., Maillard, I Tags: Research Articles Source Type: research
Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2- and TET2-Mutant Acute Myeloid Leukemia [Research Articles]
This article is highlighted in the In This Issue feature, p. 443 (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Shih, A. H., Meydan, C., Shank, K., Garrett-Bakelman, F. E., Ward, P. S., Intlekofer, A. M., Nazir, A., Stein, E. M., Knapp, K., Glass, J., Travins, J., Straley, K., Gliser, C., Mason, C. E., Yen, K., Thompson, C. B., Melnick, A., Levine, R. L. Tags: Research Articles Source Type: research
AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations [Research Articles]
This article is highlighted in the In This Issue feature, p. 443 (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Yen, K., Travins, J., Wang, F., David, M. D., Artin, E., Straley, K., Padyana, A., Gross, S., DeLaBarre, B., Tobin, E., Chen, Y., Nagaraja, R., Choe, S., Jin, L., Konteatis, Z., Cianchetta, G., Saunders, J. O., Salituro, F. G., Quivoron, C., Opolon, P., B Tags: Research Articles Source Type: research
Personalized In Vitro and In Vivo Cancer Models to Guide Precision Medicine [Research Articles]
This article is highlighted in the In This Issue feature, p. 443 (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Pauli, C., Hopkins, B. D., Prandi, D., Shaw, R., Fedrizzi, T., Sboner, A., Sailer, V., Augello, M., Puca, L., Rosati, R., McNary, T. J., Churakova, Y., Cheung, C., Triscott, J., Pisapia, D., Rao, R., Mosquera, J. M., Robinson, B., Faltas, B. M., Emerling, Tags: Research Articles Source Type: research
Optimizing Next-Generation AML Therapy: Activity of Mutant IDH2 Inhibitor AG-221 in Preclinical Models [In the Spotlight]
Summary: AG-221 or enasidenib is a first-in-class selective inhibitor of mutated isocitrate dehydrogenase 2 (IDH2) with early demonstrated clinical efficacy in acute myeloid leukemia as a single agent, yet with persistence of mutant IDH2 clones. Two articles in this issue of Cancer Discovery provide further insight into the biological activity of AG-221 in promoting differentiation of IDH2-mutant cells and reversing aberrant DNA methylation over time, and demonstrating preclinical activity in combination with a targeted FLT3 kinase inhibitor to eliminate IDH2-mutant clones. Cancer Discov; 7(5); 459–61. ©2017 AAC...
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Thomas, D., Majeti, R. Tags: In the Spotlight Source Type: research
A Road Map for Precision Cancer Medicine Using Personalized Models [In the Spotlight]
Summary: A study by Pauli and colleagues in this issue of Cancer Discovery describes the creation of a precision cancer platform for patients with advanced disease, integrating DNA sequencing of patient tumors with the generation of patient-derived organoids and xenografts. They propose the use of this platform for drug testing to nominate therapeutic options for individual patients and for therapeutic biomarker discovery. Cancer Discov; 7(5); 456–8. ©2017 AACR.
See related article by Pauli et al., p. 462. (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Authors: Picco, G., Garnett, M. J. Tags: In the Spotlight Source Type: research
PI3K Signaling Regulates ER Activity via KMT2D in ER+ Breast Cancer [Breast Cancer]
Targeting PI3Kα enhances KMT2D methyltransferase activity to promote ER-mediated transcription. (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Tags: Breast Cancer Source Type: research
Ultraviolet-Induced DNA Damage Promotes RNA m6A Methylation [DNA Damage]
m6A RNA methylation rapidly recruits Pol to UV-induced damage sites to facilitate DNA repair. (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Tags: DNA Damage Source Type: research
Peptidomimetic Inhibitors Target ERG Gene Fusions in Prostate Cancer [Prostate Cancer]
ERG inhibitory peptides promote ERG degradation and suppress the growth of TMPRSS2–ERG+ tumors. (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Tags: Prostate Cancer Source Type: research
Allosteric Plus Catalytic BCR-ABL1 Inhibitors Promote Durable Responses [Kinase Inhibitors]
A selective allosteric ABL1 kinase inhibitor suppresses the growth of BCR–ABL1-driven CML. (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Tags: Kinase Inhibitors Source Type: research
An Anti-CD47 Antibody Is Effective in Pediatric Brain Tumor Models [Brain Tumors]
The anti-CD47 antibody Hu5F9-G4 selectively kills tumor cells in pediatric brain tumor PDX models. (Source: Cancer Discovery)
Source: Cancer Discovery - April 30, 2017 Category: Cancer & Oncology Tags: Brain Tumors Source Type: research
