Noted [News in Brief]
A collection of recently published news items. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
CAR T Cells Infiltrate Brain, Target Tumors [News in Brief]
A single dose of peripherally infused CAR T cells cleared antigen-expressing tumor cells in patients with glioblastoma, a 10-person trial found. However, the cells also triggered an immunosuppressive microenvironment, and the target antigen, EGFR variant III, wasn't expressed uniformly in patients' tumors. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Biomarker for Antitumor Immunity Identified [News in Brief]
Investigators have discovered that a certain type of immune cell in tumors, known as tissue-resident memory cells, are associated with a strong immune response and improved prognosis in lung cancer. The findings may aid in selecting appropriate immunotherapies and developing more effective vaccines for a wide range of cancers. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Spreading Colon Cancer Can Bypass Lymph Nodes [News in Brief]
A new study uses evolutionary analysis to show that some colorectal tumor cells colonize the lymph nodes before metastasizing to the organs. However, the study finds that most metastases descend from subclones in the tumor itself. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
Panel OKs CAR T Therapy for Leukemia [News in Brief]
An expert panel recommended approval of Novartis's experimental chimeric antigen T-cell therapy, tisagenlecleucel, for children and young adults with relapsed or refractory B-cell acute lymphoblastic leukemia. The therapy would be the first of its kind approved for cancer and has the potential to transform standard of care for advanced blood cancers. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
People [News in Brief]
Carlos Arteaga, MD; Steven D. Leach, MD; and Paul M. Harari, MD, are highlighted. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: News in Brief Source Type: research
In This Issue [In This Issue]
(Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: In This Issue Source Type: research
Superenhancers Drive Neuroblastoma Differentiation States [Neuroblastoma]
Superenhancer-associated transcriptional networks promote neuroblastoma heterogeneity. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Neuroblastoma Source Type: research
FOXA1-Dependent Enhancer Reprogramming Promotes Metastasis [Metastasis]
Recurrent enhancer changes accompany the metastatic transition in pancreatic cancer models. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Metastasis Source Type: research
Integrative Genomics Characterize Medulloblastoma Subtypes [Medulloblastoma]
Integrative genomic analysis characterized the genomic landscapes of medulloblastoma subtypes. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Medulloblastoma Source Type: research
CAMKII{gamma} Stabilizes MYC to Promote T-cell Lymphomagenesis [Lymphoma]
Inhibition of CAMKII reduces MYC protein levels, T-cell lymphomagenesis, and tumor burden in vivo. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Lymphoma Source Type: research
Transcription Elongation Factors Are Potential Targets in Glioblastoma [Glioblastoma]
JMJD6 promotes transcription pause-release and elongation and glioblastoma cell survival in vivo. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Glioblastoma Source Type: research
Biallelic Germline Mutations in RFWD3 May Induce Fanconi Anemia [Fanconi Anemia]
The E3 ubiquitin ligase RFWD3 is mutated in a patient with Fanconi anemia lacking known Fanconi mutations. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Fanconi Anemia Source Type: research
GPX4 Blocks Ferroptosis to Drive the Survival of Chemoresistant Cells [Drug Resistance]
The lipid peroxidase GPX4 is critical for the survival of therapy-resistant ZEB1+ cancer cells. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Drug Resistance Source Type: research
Disrupting the APC-Asef Interaction Suppresses Cancer Cell Migration [Drug Design]
Structure-based design yields peptidomimetic APC–ARM pocket inhibitors that block Asef binding. (Source: Cancer Discovery)
Source: Cancer Discovery - August 31, 2017 Category: Cancer & Oncology Tags: Drug Design Source Type: research
