Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity
Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Jacqulyne P. Robichaux, Yasir Y. Elamin, R.S.K. Vijayan, Monique B. Nilsson, Lemei Hu, Junqin He, Fahao Zhang, Marlese Pisegna, Alissa Poteete, Huiying Sun, Shuai Li, Ting Chen, Han Han, Marcelo Vailati Negrao, Jordi Rodon Ahnert, Lixia Diao, Jing Wang, Xiuning Le, Funda Meric-Bernstam, Mark Routbort (Source: Cancer Cell)
Source: Cancer Cell - March 18, 2020 Category: Cancer & Oncology Source Type: research
An Integrated Gene Expression Landscape Profiling Approach to Identify Lung Tumor Endothelial Cell Heterogeneity and Angiogenic Candidates
Publication date: 16 March 2020Source: Cancer Cell, Volume 37, Issue 3Author(s): Jermaine Goveia, Katerina Rohlenova, Federico Taverna, Lucas Treps, Lena-Christin Conradi, Andreas Pircher, Vincent Geldhof, Laura P.M.H. de Rooij, Joanna Kalucka, Liliana Sokol, Melissa García-Caballero, Yingfeng Zheng, Junbin Qian, Laure-Anne Teuwen, Shawez Khan, Bram Boeckx, Els Wauters, Herbert Decaluwé, Paul De Leyn, Johan Vansteenkiste (Source: Cancer Cell)
Source: Cancer Cell - March 18, 2020 Category: Cancer & Oncology Source Type: research
Neurofibromin Is an Estrogen Receptor-α Transcriptional Co-repressor in Breast Cancer
Publication date: Available online 5 March 2020Source: Cancer CellAuthor(s): Ze-Yi Zheng, Meenakshi Anurag, Jonathan T. Lei, Jin Cao, Purba Singh, Jianheng Peng, Hilda Kennedy, Nhu-Chau Nguyen, Yue Chen, Philip Lavere, Jing Li, Xin-Hui Du, Burcu Cakar, Wei Song, Beom-Jun Kim, Jiejun Shi, Sinem Seker, Doug W. Chan, Guo-Qiang Zhao, Xi Chen (Source: Cancer Cell)
Source: Cancer Cell - March 6, 2020 Category: Cancer & Oncology Source Type: research
Mutant ACVR1 Arrests Glial Cell Differentiation to Drive Tumorigenesis in Pediatric Gliomas
Publication date: Available online 5 March 2020Source: Cancer CellAuthor(s): Jerome Fortin, Ruxiao Tian, Ida Zarrabi, Graham Hill, Eleanor Williams, Gonzalo Sanchez-Duffhues, Midory Thorikay, Parameswaran Ramachandran, Robert Siddaway, Jong Fu Wong, Annette Wu, Lorraine N. Apuzzo, Jillian Haight, Annick You-Ten, Bryan E. Snow, Andrew Wakeham, David J. Goldhamer, Daniel Schramek, Alex N. Bullock, Peter ten Dijke (Source: Cancer Cell)
Source: Cancer Cell - March 6, 2020 Category: Cancer & Oncology Source Type: research
Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer
Publication date: Available online 27 February 2020Source: Cancer CellAuthor(s): Daniel J. McGrail, Jeannine Garnett, Jun Yin, Hui Dai, David J.H. Shih, Truong Nguyen Anh Lam, Yang Li, Chaoyang Sun, Yongsheng Li, Rosemarie Schmandt, Ji Yuan Wu, Limei Hu, Yulong Liang, Guang Peng, Eric Jonasch, David Menter, Melinda S. Yates, Scott Kopetz, Karen H. Lu, Russell Broaddus (Source: Cancer Cell)
Source: Cancer Cell - February 28, 2020 Category: Cancer & Oncology Source Type: research
CDK4/6 Inhibitors Impair Recovery from Cytotoxic Chemotherapy in Pancreatic Adenocarcinoma
Publication date: Available online 27 February 2020Source: Cancer CellAuthor(s): Beatriz Salvador-Barbero, Mónica Álvarez-Fernández, Elisabet Zapatero-Solana, Aicha El Bakkali, María del Camino Menéndez, Pedro P. López-Casas, Tomas Di Domenico, Tao Xie, Todd VanArsdale, David J. Shields, Manuel Hidalgo, Marcos Malumbres (Source: Cancer Cell)
Source: Cancer Cell - February 28, 2020 Category: Cancer & Oncology Source Type: research
Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer
Publication date: 10 February 2020Source: Cancer Cell, Volume 37, Issue 2Author(s): Sharanya Sivanand, Matthew G. Vander HeidenMetabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer. (Source: Cancer Cell)
Source: Cancer Cell - February 12, 2020 Category: Cancer & Oncology Source Type: research
Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T-cell Leukemogenesis
Publication date: 10 February 2020Source: Cancer Cell, Volume 37, Issue 2Author(s): Jue Jiang, Jingchao Wang, Ming Yue, Xiaolian Cai, Tianci Wang, Chao Wu, Hexiu Su, Yanwu Wang, Meng Han, Yingchi Zhang, Xiaofan Zhu, Peng Jiang, Peng Li, Yonghua Sun, Wuhan Xiao, Hui Feng, Guoliang Qing, Hudan LiuSummaryDeregulation of MYC plays an essential role in T cell acute lymphoblastic leukemia (T-ALL), yet the mechanisms underlying its deregulation remain elusive. Herein, we identify a molecular mechanism responsible for reciprocal activation between Aurora B kinase (AURKB) and MYC. AURKB directly phosphorylates MYC at serine 67, co...
Source: Cancer Cell - February 12, 2020 Category: Cancer & Oncology Source Type: research
The Repertoire of Serous Ovarian Cancer Non-genetic Heterogeneity Revealed by Single-Cell Sequencing of Normal Fallopian Tube Epithelial Cells
Publication date: 10 February 2020Source: Cancer Cell, Volume 37, Issue 2Author(s): Zhiyuan Hu, Mara Artibani, Abdulkhaliq Alsaadi, Nina Wietek, Matteo Morotti, Tingyan Shi, Zhe Zhong, Laura Santana Gonzalez, Salma El-Sahhar, Mohammad KaramiNejadRanjbar, Garry Mallett, Yun Feng, Kenta Masuda, Yiyan Zheng, Kay Chong, Stephen Damato, Sunanda Dhar, Leticia Campo, Riccardo Garruto Campanile, Hooman Soleymani majdSummaryThe inter-differentiation between cell states promotes cancer cell survival under stress and fosters non-genetic heterogeneity (NGH). NGH is, therefore, a surrogate of tumor resilience but its quantification is...
Source: Cancer Cell - February 12, 2020 Category: Cancer & Oncology Source Type: research
Comparative Molecular Life History of Spontaneous Canine and Human Gliomas
Publication date: 10 February 2020Source: Cancer Cell, Volume 37, Issue 2Author(s): Samirkumar B. Amin, Kevin J. Anderson, C. Elizabeth Boudreau, Emmanuel Martinez-Ledesma, Emre Kocakavuk, Kevin C. Johnson, Floris P. Barthel, Frederick S. Varn, Cynthia Kassab, Xiaoyang Ling, Hoon Kim, Mary Barter, Ching C. Lau, Chew Yee Ngan, Margaret Chapman, Jennifer W. Koehler, James P. Long, Andrew D. Miller, C. Ryan Miller, Brian F. PorterSummarySporadic gliomas in companion dogs provide a window on the interaction between tumorigenic mechanisms and host environment. We compared the molecular profiles of canine gliomas with those of h...
Source: Cancer Cell - February 12, 2020 Category: Cancer & Oncology Source Type: research
Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
Publication date: 10 February 2020Source: Cancer Cell, Volume 37, Issue 2Author(s): Dhivya R. Sudhan, Angel Guerrero-Zotano, Helen Won, Paula González Ericsson, Alberto Servetto, Mariela Huerta-Rosario, Dan Ye, Kyung-min Lee, Luigi Formisano, Yan Guo, Qi Liu, Lisa N. Kinch, Monica Red Brewer, Teresa Dugger, James Koch, Michael J. Wick, Richard E. Cutler, Alshad S. Lalani, Richard Bryce, Alan Auerbach (Source: Cancer Cell)
Source: Cancer Cell - February 12, 2020 Category: Cancer & Oncology Source Type: research
EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition
Publication date: Available online 30 January 2020Source: Cancer CellAuthor(s): Sergey Karakashev, Takeshi Fukumoto, Bo Zhao, Jianhuang Lin, Shuai Wu, Nail Fatkhutdinov, Pyoung-Hwa Park, Galina Semenova, Stephanie Jean, Mark G. Cadungog, Mark E. Borowsky, Andrew V. Kossenkov, Qin Liu, Rugang ZhangSummaryIn response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a critical role in the choice between homologous recombination (HR) and non-homologous end-joining (NHEJ)-mediated repair. Here we show that EZH2 inhibition upregulates MAD2L2 and sensitizes HR-proficient epithelial ovarian cancer (EOC) to pol...
Source: Cancer Cell - January 31, 2020 Category: Cancer & Oncology Source Type: research
THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells
Publication date: Available online 30 January 2020Source: Cancer CellAuthor(s): Chuang Sun, Peishun Shou, Hongwei Du, Koichi Hirabayashi, Yuhui Chen, Laura E. Herring, Sarah Ahn, Yang Xu, Kyogo Suzuki, Guangming Li, Ourania Tsahouridis, Lishan Su, Barbara Savoldo, Gianpietro DottiSummaryChimeric antigen receptor (CAR) T cell costimulation mediated by CD28 and 4-1BB is essential for CAR-T cell-induced tumor regression. However, CD28 and 4-1BB differentially modulate kinetics, metabolism and persistence of CAR-T cells, and the mechanisms governing these differences are not fully understood. We found that LCK recruited into ...
Source: Cancer Cell - January 31, 2020 Category: Cancer & Oncology Source Type: research
Science that Inspires
Publication date: Available online 23 January 2020Source: Cancer CellAuthor(s): The Cell Press Team (Source: Cancer Cell)
Source: Cancer Cell - January 25, 2020 Category: Cancer & Oncology Source Type: research
Hyperactivation of TORC1 Drives Resistance to the Pan-HER Tyrosine Kinase Inhibitor Neratinib in HER2-Mutant Cancers
Publication date: Available online 23 January 2020Source: Cancer CellAuthor(s): Dhivya R. Sudhan, Angel Guerrero-Zotano, Helen Won, Paula González Ericsson, Alberto Servetto, Mariela Huerta-Rosario, Dan Ye, Kyung-min Lee, Luigi Formisano, Yan Guo, Qi Liu, Lisa N. Kinch, Monica Red Brewer, Teresa Dugger, James Koch, Michael J. Wick, Richard E. Cutler, Alshad S. Lalani, Richard Bryce, Alan AuerbachSummaryWe developed neratinib-resistant HER2-mutant cancer cells by gradual dose escalation. RNA sequencing identified TORC1 signaling as an actionable mechanism of drug resistance. Primary and acquired neratinib resistance in HER...
Source: Cancer Cell - January 25, 2020 Category: Cancer & Oncology Source Type: research
