Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

Publication date: 10 February 2020Source: Cancer Cell, Volume 37, Issue 2Author(s): Sharanya Sivanand, Matthew G. Vander HeidenMetabolic pathways must be adapted to support cell processes required for transformation and cancer progression. Amino acid metabolism is deregulated in many cancers, with changes in branched-chain amino acid metabolism specifically affecting cancer cell state as well as systemic metabolism in individuals with malignancy. This review highlights key concepts surrounding the current understanding of branched-chain amino acid metabolism and its role in cancer.
Source: Cancer Cell - Category: Cancer & Oncology Source Type: research