Birth Defects Research Part B: Developmental and Reproductive Toxicology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Effects of Maternal Exposure to Piperonyl Butoxide (PBO) on Behavioral Development in F1‐Generation Mice
Female mice were exposed maternally to piperonyl butoxide (PBO) through diet to provide dietary levels of 0% (control), 0.01%, 0.03%, and 0.09% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in the F1 generation. There was no adverse effect of PBO on litter size, litter weight, or sex ratio at birth. The average body weights of male offspring decreased significantly in dose‐related manners on postnatal days (PNDs) 0, 4, 7, and 14 (p = 0.0019, 0.0096, 0.033, and 0.038, respectively) during the lactation period. In female offspring, the average body weights de...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - August 1, 2015 Category: Perinatology & Neonatology Authors: Toyohito Tanaka, Akiko Inomata Tags: Original Article Source Type: research

The Effect of Dofetilide on the Heart Rate of GD11 and GD13 Rat Embryos, in vivo, Using Ultrasound
CONCLUSIONSUltrasound is a useful technique to investigate the effect of maternally administered drugs on the embryonic HR in the rat. The results may provide more information about the safety of these drugs in pregnancy leading to better risk assessment for the human (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - August 1, 2015 Category: Perinatology & Neonatology Authors: Helen Ritchie, Diana Oakes, Tzong‐tyng Hung, Elizabeth Hegedus, Shreya Sood, William Webster Tags: Research Article Source Type: research

Impact of Early Postnatal NSAID Treatment on Nephrogenesis in Wistar Rats
CONCLUSIONA clinical Ibuprofen dose showed potential to inhibit kidney development in neonatal rats. FR did not modulate these effects (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - August 1, 2015 Category: Perinatology & Neonatology Authors: Ruud R. G. Bueters, Annelies Klaasen, Nuria Maicas, Sandrine Florquin, Lambertus P. Heuvel, Michiel F. Schreuder Tags: Original Article Source Type: research

Effect of Himatanthus sucuuba in Maternal Reproductive Outcome and Fetal Anomaly Frequency in Rats
The aim of this study was to evaluate the effect of Himatanthus sucuuba on the maternal reproductive outcome and fetal anomaly incidence in rats. Pregnant rats were randomly divided into three experimental groups as follows: Control = treated with water (vehicle), treated 250 = treated with H. sucuuba at dose 250 mg/kg, and treated 500 = treated with H. sucuuba at dose 500 mg/kg. The rats were orally treated, by gavage, with H. sucuuba or vehicle (water) during preimplantation and organogenic period (from gestational day 0–14). At day 21 of pregnancy, all rats were killed to obtain maternal–fetal data. The treatment wi...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - August 1, 2015 Category: Perinatology & Neonatology Authors: Thaigra Soares, Débora Cristina Damasceno, Wilma De Grava Kempinas, Flávia Mayara Campos Resende, Maria Aparecida Correa dos Santos, Clélia Akiko Hiruma‐Lima, Gustavo Tadeu Volpato Tags: Research Article Source Type: research

The Effect of Exposure to Atrazine on Dopaminergic Development in Pubertal Male SD Rats
In this study, we examined the hypothesis that pubertal exposure to ATR would disrupt the development of the nigrostriatal dopamine (DA) system. The content of DA and levodopa (L‐DA) were examined in striatum samples by HPLC‐FL, and the mRNA and protein expression of tyrosine hydroxylase, orphan nuclear hormone receptor (Nurr1), Nurr1 interacting protein (NuIP), and cyclin‐dependent kinase inhibitors of the Cip̲Kip family (p57kip2) were examined in samples of the nigrostriatum by use of fluorescence Real‐Time quantitative polymerase chain reaction (PCR). Exposure of juvenile rats to the high dose of ATR led to red...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - August 1, 2015 Category: Perinatology & Neonatology Authors: Yan‐Shu Li, Xi He, Kun Ma, Yan‐Ping Wu, Bai‐Xiang Li Tags: Research Article Source Type: research

Valproic Acid Induces the Hyperacetylation of P53, Expression of P53 Target Genes, and Markers of the Intrinsic Apoptotic Pathway in Midorganogenesis Murine Limbs
In utero exposure to valproic acid (VPA), an anticonvulsant and histone deacetylase inhibitor (HDACi), increases the risk of congenital malformations. Although the mechanisms leading to the teratogenicity of VPA remain unsolved, several HDAC inhibitors increase cell death in cancer cell lines and embryonic tissues. Moreover, P53, the master regulator of apoptosis, is an established HDAC target. The purpose of this study was to investigate the effects of VPA on P53 signaling and markers of apoptosis during midorganogenesis in vitro limb development. Timed‐pregnant CD1 mice (gestation day 12) were euthanized; embryonic for...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - August 1, 2015 Category: Perinatology & Neonatology Authors: France‐Hélène Paradis, Barbara F. Hales Tags: Research Article Source Type: research

Corrigendum
(Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - July 27, 2015 Category: Perinatology & Neonatology Tags: Corrigendum Source Type: research

Issue Information
(Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - July 27, 2015 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Developmental Toxicity and Fertility Assessment in Rabbits with Tabalumab: A Human IgG4 Monoclonal Antibody
In conclusion, no adverse reproductive or developmental effects were observed in rabbits following exposure to tabalumab at doses as high as 30 mg/kg and exposures at least 14‐fold greater than human exposure levels. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - July 20, 2015 Category: Perinatology & Neonatology Authors: William J. Breslin, Kim G. Hilbish, Jennifer A. Martin, Carolyn A. Halstead, Tammy L. Edwards Tags: Research Article Source Type: research

Time Course for Onset and Recovery from Effects of a Novel Male Reproductive Toxicant: Implications for Apical Preclinical Study Designs
In the pharmaceutic ICH S5(R2) guidelines for reproductive toxicity testing, a premating dose duration of 14 days is considered sufficient for assessment of male fertility for compounds that are not testicular toxicants. A novel α7 subtype of nicotinic acetylcholine receptor (α7nAChR) agonist, originally intended for treatment of Alzheimer's disease, did not cause changes in sperm counts, motility, or testicular histopathology in rat toxicity studies of up to 6 months duration. However, profound decrements in male fertility (reduced pregnancy rates and litter sizes) occurred after 11 weeks of dosing in male rats. In two ...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - July 20, 2015 Category: Perinatology & Neonatology Authors: Nicola Powles‐Glover, Terri Mitchard, Jane Stewart Tags: Research Article Source Type: research

Agent Orange Exposure and 2,3,7,8‐Tetrachlorodibenzo‐p‐Dioxin (TCDD) in Human Milk
Agent Orange was sprayed in parts of southern Vietnam during the U.S.‐Vietnam war and was a mixture of two chlorophenoxy herbicides. The mixture was contaminated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD). TCDD and other dioxins and furans are measurable in the milk of Vietnamese women. We explored whether the TCDD in milk from these women was from Agent Orange and whether lactational exposure can be a mode of transgenerational effects of TCDD from Agent Orange. A review of the world's literature on milk concentrations of polychlorinated compounds showed the presence of TCDD and other dioxins and furans in all...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - July 20, 2015 Category: Perinatology & Neonatology Authors: Anthony R. Scialli, Deborah K. Watkins, Michael E. Ginevan Tags: Review Article Source Type: research

Issue Information
(Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - June 27, 2015 Category: Perinatology & Neonatology Tags: Issue Information Source Type: research

Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446‐Part I: Effects on Embryo‐Fetal Development in New Zealand White Rabbits and Sprague Dawley Rats
The pharmacotoxicology impacts of dietary supplements taken at the time of pregnancy have remained alarming since women are the frequent herbal medicine users in many countries as a complement to the conventional pregnancy management. The use of herbal medicines and diet supplements in expectant mothers linked closely to the health of the childbearing mothers and the fetuses where the lack of developmental safety data imposes a challenge to make the right choices. Here, we describe the potential adverse effects of UP446, a standardized bioflavonoid composition from the roots of Scutellaria baicalensis and the heartwoods of...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - June 1, 2015 Category: Perinatology & Neonatology Authors: Mesfin Yimam, Young‐Chul Lee, Eu‐Jin Hyun, Qi Jia Tags: Research Article Source Type: research

An Enhanced Pre‐ and Postnatal Development Study in Cynomolgus Monkeys with Tabalumab: A Human IgG4 Monoclonal Antibody
In conclusion, the no‐observed‐adverse‐effect level for maternal and developmental toxicity was 30 mg/kg, the highest dose tested. Exposures at 30 mg/kg provide a margin of safety of 16× the anticipated clinical exposure. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - April 1, 2015 Category: Perinatology & Neonatology Authors: William J. Breslin, Kim G. Hilbish, Jennifer A. Martin, Carolyn A. Halstead, Deanna L. Newcomb, Gary J. Chellman Tags: Research Article Source Type: research

Reproductive and Developmental Toxicity of Orally Administered Botanical Composition, UP446‐Part III: Effects on Fertility and Early Embryonic Development to Implantation in Sprague Dawley Rats
In recent years, high prevalence of adverse effects associated to the use of traditional medicines during pregnancy is becoming alarming due to the self‐medication of oral supplements by expecting mothers without supervision. Many expectant mothers use alternative and complementary medicines as a supplement to conventional pregnancy management with an inherent belief of considering herbal remedies as harmless. To the contrary, herbal remedies could incur a potential teratogenic risk both to the child bearing mother and the developing fetuses when consumed before or at the time of gestation. Here, we describe the potentia...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - April 1, 2015 Category: Perinatology & Neonatology Authors: Mesfin Yimam, Young‐Chul Lee, Eu‐Jin Hyun, Qi Jia Tags: Research Article Source Type: research