Birth Defects Research Part B: Developmental and Reproductive Toxicology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The Inhibin B Response to the Testicular Toxicant 1, 3 Dinitrobenzene in Male Rats
CONCLUSIONSChanges in serum Inhibin B levels were detected only in association with moderate or severe testicular toxicity as evidenced by histopathology and is therefore considered to be of limited value as a biomarker for Sertoli cell toxicity. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Manisha Sonee, Nancy Bogdan, LeRoy Hall, Stewart Bryant, Petra Vinken Tags: Original Article Source Type: research

The Inhibin B Response to Testicular Toxicants Ethylene Glycol Monomethyl Ether or Dibromoacetic Acid in Male Rats
CONCLUSIONSSerum inhibin B levels in rats provided a signal of testicular toxicity for each of these known testicular toxicants administered at high levels; however, histopathology provided the earliest evidence of toxic effects. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Brian P. Enright, Belen Tornesi, Helga Lorenz, Katharine Whitney Tags: Original Article Source Type: research

The Inhibin B Response in Male Rats Treated with Two Drug Candidates
CONCLUSIONWe conclude that in these two studies there was a poor correlation between changes in serum levels of Inhibin B and testis histopathology. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Robert E. Chapin, James D. Alvey, Richard A. Goldstein, Melba G. Dokmanovich, William J. Reagan, Kjell Johnson, Frank J. Geoly Tags: Original Article Source Type: research

The Inhibin B Response to a Motilin Receptor Agonist in Male Rats
CONCLUSIONThere was poor correlation between changes in serum levels of Inhibin B and testis histopathology. Based on these observations, the utility of Inhibin B as a hormonal marker for germ cell toxicity is limited. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Mary K. Ziejewski, Justin D. Vidal, Dinesh Stanislaus, April Apostoli, Probash Chowdhury, Susan Laffan Tags: Orginal Article Source Type: research

The Inhibin B (InhB) Response to the Testicular Toxicants Mono‐2‐Ethylhexyl Phthalate (MEHP), 1,3 Dinitrobenzene (DNB), or Carbendazim (CBZ) Following Short‐term Repeat Dosing in the Male Rat
CONCLUSIONIn conclusion, under the conditions of these studies, changes in InhB were not an effective early onset marker of testicular toxicity or an effective marker for slight to moderate levels of acute injury, and only reflected more severe disruption of spermatogenesis. Changes in plasma InhB and follicle stimulating hormone were poorly correlated except in some instances of moderate to marked testicular toxicity. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: William J. Breslin, April Paulman, Denise Sun‐Lin, Keith M. Goldstein, Angela Derr Tags: Original Article Source Type: research

The Inhibin B Response in Male Rats Treated with a GnRH Agonist and an Endothelin Receptor Antagonist
CONCLUSIONInhibin B showed a good correlation with testicular pathology for GnRH‐A, and following ET‐An administration appeared to give a signal that might reflect changes in tubular function in the absence of degenerative pathology. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Michelle Coulson, Terri Mitchard, Sue Bickerton, Jayne Harris, Catherine Betts, Jane Stewart Tags: Original Article Source Type: research

Inhibin B as a Marker of Sertoli Cell Damage and Spermatogenic Disturbance in the Rat
This study was designed to determine the effects of Compound A on spermatogenesis including assessment of inhibin B levels and on fertility in the male rat over a 15 to 19 weeks treatment and a 19 weeks treatment‐free period in control and 30, 60, and 180 mg/kg dose groups (n = 22/group). Compound A in a dose‐dependent manner induced various degrees of spermatogenic alterations compatible with Sertoli cells being the primary target, for example, inter‐ and intracellular Sertoli cell vacuolization and altered cellular morphology followed by germ cell degeneration and marked reduction of epididymidal sperm numbers. Bl...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Tamara Pfaff, Jon Rhodes, Martin Bergmann, Gerhard F. Weinbauer Tags: Original Article Source Type: research

Analytic Evaluation of a Human ELISA Kit for Measurement of Inhibin B in Rat Samples
CONCLUSIONSThe assay meets the analytical performance criteria; however, precision at the low end of the standard curve, biological variability, and low control values observed in some laboratories indicate that the utility of the assay may be limited in some laboratories. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Michelle Coulson, Sue Bickerton, Catherine J Betts, Matt Jacobsen, Jane Stewart, Robert E. Chapin, William J. Reagan, James Alvey, Zoltan Erdos, Louise Parks Saldutti, Manisha Sonee, Nancy Bogdan, Monica Singer, Petra Vinken, Valerie Barlow, Karen Czajkow Tags: Original Article Source Type: research

Introduction to the HESI‐Sponsored Inhibin Consortium
(Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - January 24, 2013 Category: Perinatology & Neonatology Authors: Robert E. Chapin, James H. Kim Tags: Review Article Source Type: research

Assessment of Inhibin B as a Biomarker of Testicular Injury Following Administration of Carbendazim, Cetrorelix, or 1,2‐Dibromo‐3‐Chloropropane in Wistar Han Rats
This study investigates the correlation of Inhibin B in Wistar Han rats with the onset and reversibility of testicular histopathology from classical testicular toxicants carbendazim, cetrorelix acetate (CTX), and 1,2‐dibromo‐3‐chloropropane (DBCP). The dose regimen included Interim (day 8), Drug (day 29), and nondosing Recovery (day 58) Phases. Inhibin B was not effective at predicting the onset of carbendazim‐ or CTX‐mediated testicular pathology in rats. Inhibin B was reduced by DBCP administration at the end of the Drug Phase only, acting as a leading indicator of the onset of testicular toxicity before the on...
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 1, 2012 Category: Perinatology & Neonatology Authors: Jeffrey S. Moffit, Leah S. Her, Anthony M. Mineo, Brian L. Knight, Jonathan A. Phillips, Michael S. Thibodeau Tags: Original Article Source Type: research

Inhibin B in Plasma Samples from Male Volunteer Panel Selected for Health but Not Fertility: Sources of Variability
CONCLUSIONThese results illustrate that when undertaking longitudinal monitoring of inhibin B in clinical trials as means of monitoring testicular function, it is important to obtain samples from an individual at the same time of day and to use statistical methods which analyze the magnitude of deviation of an individual from their personal baseline as well as looking at group means and influence of study duration. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 1, 2012 Category: Perinatology & Neonatology Authors: Jane Stewart, Sue Bickerton, Catherine J Betts, Sarah Kirk Tags: Original Article Source Type: research

Decreased Expression of GATA4 in the Diaphragm of Nitrofen‐Induced Congenital Diaphragmatic Hernia
CONCLUSIONSWe provide evidence for the first time that diaphragmatic expression of GATA4 is downregulated in the nitrofen model, suggesting that decreased expression of GATA4 may impair diaphragmatic development in nitrofen‐induced CDH. (Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology)
Source: Birth Defects Research Part B: Developmental and Reproductive Toxicology - December 18, 2007 Category: Perinatology & Neonatology Authors: Jens Dingemann, Takashi Doi, Jan‐Hendrik Gosemann, Elke Maria Ruttenstock, Nana Nakazawa, Prem Puri Tags: Original Article Source Type: research