Effect of Grain Sizes on Mechanical Properties and Biodegradation Behavior of Pure Iron for Cardiovascular Stent Application.
Authors: Obayi CS, Tolouei R, Mostavan A, Paternoster C, Turgeon S, Okorie BA, Obikwelu DO, Mantovani D
Abstract
Abstract Pure iron has been demonstrated as a potential candidate for biodegradable metal stents due to its appropriate biocompatibility, suitable mechanical properties and uniform biodegradation behavior. The competing parameters that control the safety and the performance of BMS include proper strength-ductility combination, biocompatibility along with matching rate of corrosion with healing rate of arteries. Being a micrometre-scale biomedical device, the mentioned variables have been found t...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Interfacing polymeric scaffolds with primary pancreatic ductal adenocarcinoma cells to develop 3D cancer models.
In conclusion, primary PDAC cells showed diverse behaviors while interacting with different scaffold types that can be potentially exploited to create stage-specific pancreatic cancer models likely to provide new knowledge on the modulation and drug susceptibility of MMPs.
PMID: 25482337 [PubMed - indexed for MEDLINE] (Source: Biomatter)
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Influence of ECAP process on mechanical and corrosion properties of pure Mg and ZK60 magnesium alloy for biodegradable stent applications.
Authors: Mostaed E, Vedani M, Hashempour M, Bestetti M
Abstract
Equal channel angular pressing (ECAP) was performed on ZK60 alloy and pure Mg in the temperature range 150-250 °C. A significant grain refinement was detected after ECAP, leading to an ultrafine grain size (UFG) and enhanced formability during extrusion process. Comparing to conventional coarse grained samples, fracture elongation of pure Mg and ZK60 alloy were significantly improved by 130% and 100%, respectively, while the tensile strength remained at high level. Extrusion was performed on ECAP processed billets to produce small tubes (with...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
The effects of a SiO2 coating on the corrosion parameters cpTi and Ti-6Al-7Nb alloy.
Authors: Basiaga M, Walke W, Paszenda Z, Karasiński P, Szewczenko J
Abstract
The aim of this paper was to evaluate the usefulness of the sol-gel method application, to modificate the surface of the Ti6Al7Nb alloy and the cpTi titanium (Grade 4) with SiO2 oxide, applied on the vascular implants to improve their hemocompatibility. Mechanical treatment was followed by film deposition on surface of the titanium samples. An appropriate selection of the process parameters was verified in the studies of corrosion, using potentiodynamic and impedance method. A test was conducted in the solution simulating blood v...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Poly(vinyl alcohol) hydrogel coatings with tunable surface exposure of hydroxyapatite.
Authors: Moreau D, Villain A, Ku DN, Corté L
Abstract
Insufficient bone anchoring is a major limitation of artificial substitutes for connective osteoarticular tissues. The use of coatings containing osseoconductive ceramic particles is one of the actively explored strategies to improve osseointegration and strengthen the bone-implant interface for general tissue engineering. Our hypothesis is that hydroxyapatite (HA) particles can be coated robustly on specific assemblies of PVA hydrogel fibers for the potential anchoring of ligament replacements. A simple dip-coating method is described to produce compo...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Dextran grafting on PTFE surface for cardiovascular applications.
Authors: Michel EC, Montaño-Machado V, Chevallier P, Labbé-Barrère A, Letourneur D, Mantovani D
Abstract
The modification of biomaterial surfaces with biomolecules influences the biological response. In this work, caboxymethyldextrans (CMD) with different degrees of substitution have been grafted to surfaces by introduction of amino moieties directly onto the substrate surface. Polytetrafluoroethylene was selected as a model substrate for biomaterial as it is already largely used for cardiovascular clinical applications. Firstly, CMD polymers were characterized by FTIR, (1)H-NMR, and conductimetric titr...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Platinum metallization for MEMS application. Focus on coating adhesion for biomedical applications.
Authors: Guarnieri V, Biazi L, Marchiori R, Lago A
Abstract
The adherence of Platinum thin film on Si/SiO2 wafer was studies using Chromium, Titanium or Alumina (Cr, Ti, Al2O3) as interlayer. The adhesion of Pt is a fundamental property in different areas, for example in MEMS devices, which operate at high temperature conditions, as well as in biomedical applications, where the problem of adhesion of a Pt film to the substrate is known as a major challenge in several industrial applications health and in biomedical devices, such as for example in the stents. We investigated the properties of Chromium, Tita...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Nanotemplated polyelectrolyte films as porous biomolecular delivery systems. Application to the growth factor BMP-2.
We report here on the loading and release of the growth factor bone morphogenetic protein 2 (BMP-2), and the influence of BMP-2 loaded films on contacting murine C2C12 myoblasts. We observe nanotemplating to enable stable BMP-2 loading throughout the thickness of the film, and find the nanotemplated film to exhibit comparable cell adhesion, and enhanced cell differentiation, compared with a non-porous cross-linked film (where BMP-2 loading is mainly confined to the film surface).
PMID: 25482416 [PubMed - indexed for MEDLINE] (Source: Biomatter)
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
A brief review of mathematical models of thin film growth and surfaces. A possible route to avoid defects in stents.
Authors: Forgerini FL, Marchiori R
Abstract
The morphology of thin films has been extensively studied in the last years. The properties of a thin film are closely related to its microstructure, especially to its morphology and surface roughness. Optical reflectivity, conductivity, and porosity are characteristics that depend on the film structure. The knowledge of atomistic details of the thin film growth process is useful for the development of new techniques and the control of thin films and new materials. Models of growth process are very powerful tools that can help researchers to predict and control p...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
On the potential for fibronectin/phosphorylcholine coatings on PTFE substrates to jointly modulate endothelial cell adhesion and hemocompatibility properties.
In conclusion, FN-PRC coating improves cell adhesion and non-thrombogenic properties, thus revealing a certain potential for the development of this combined deposition strategy in cardiovascular applications.
PMID: 25785369 [PubMed - in process] (Source: Biomatter)
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Development of a novel carrier optimized for cell sheet transplantation.
In this study, we examined the utility of a novel, poly(lactic acid)-based carrier for cell sheets transplantation to the cornea of dogs and the skin of rats. The poly(lactic acid)-based carrier easily picked a cell sheet up from the dish, fit to the shape of the transplantation sites, and saved time for cell sheets detachment comparing to a conventional carrier. Thus, the poly(lactic acid)-based carrier would be useful for easy cell sheet transplantations.
PMID: 25869322 [PubMed - in process] (Source: Biomatter)
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Cell infiltration into a 3D electrospun fiber and hydrogel hybrid scaffold implanted in the brain.
Authors: Rivet CJ, Zhou K, Gilbert RJ, Finkelstein DI, Forsythe JS
Abstract
Tissue engineering scaffolds are often designed without appropriate consideration for the translational potential of the material. Solid scaffolds implanted into central nervous system (CNS) tissue to promote regeneration may require tissue resection to accommodate implantation. Or alternatively, the solid scaffold may be cut or shaped to better fit an irregular injury geometry, but some features of the augmented scaffold may fail to integreate with surrounding tissue reducing regeneration potential. To create a biomaterial able to...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Small-sized granules of biphasic bone substitutes support fast implant bed vascularization.
Authors: Barbeck M, Dard M, Kokkinopoulou M, Markl J, Booms P, Sader RA, Kirkpatrick CJ, Ghanaati S
Abstract
The present study investigated the influence of granule size of 2 biphasic bone substitutes (BoneCeramic® 400-700 μm and 500-1000 μm) on the induction of multinucleated giant cells (MNGCs) and implant bed vascularization in a subcutaneous implantation model in rats. Furthermore, degradation mechanisms and particle phagocytosis of both materials were examined by transmission electron microscopy (TEM). Both granule types induced tissue reactions involving primarily mononuclear cells and only smal...
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
Strontium ranelate improves the interaction of osteoblastic cells with titanium substrates: Increase in cell proliferation, differentiation and matrix mineralization.
In conclusion, strontium ranelate improved the interaction of osteoblastic cells with titanium substrates, increasing cell proliferation and differentiation into mature osteoblasts and the production of bone-like mineralized matrix for all substrates. This study highlights a promising role of strontium ranelate on enhancing the clinical success of bone implants, particularly in patients with osteoporosis.
PMID: 26176488 [PubMed - as supplied by publisher] (Source: Biomatter)
Source: Biomatter - November 20, 2015 Category: Biotechnology Tags: Biomatter Source Type: research
