Best Practice and Research. Clinical Gastroenterology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

The role of smoking and alcohol behaviour in the management of inflammatory bowel disease
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Mais Khasawneh, Andrew D. Spence, Jennifer Addley, Patrick B. AllenAbstractIn the era of increasing use of immunosuppressive and biologic therapy for inflammatory bowel disease, environmental influences remain important independent risk factors to modify the course of the disease, affect the need for surgery and recurrence rates post-surgical resection. The effect of smoking on inflammatory bowel disease has been established over the decades, however the exact mechanism of how smoking affects remains as ar...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Key role of local acetaldehyde in upper GI tract carcinogenesis
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Mikko SalaspuroAbstractEthanol is neither genotoxic nor mutagenic. Its first metabolite acetaldehyde, however, is a powerful local carcinogen. Point mutation in ALDH2 gene proves the causal relationship between acetaldehyde and upper digestive tract cancer in humans. Salivary acetaldehyde concentration and exposure time are the two major and quantifiable factors regulating the degree of local acetaldehyde exposure in the ideal target organ, oropharynx. Instant microbial acetaldehyde formation from alcohol ...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Alcohol, smoking and the liver disease patient
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Hannes HagströmAbstractAlcohol is an established risk factor for cirrhosis. Current recommendations for a “safe” limit for alcohol consumption are usually set to around 30 g of alcohol per day for men and 20 g per day for women, but evidence is mounting that these cut-offs might be set too high. Also, inter-individual differences in the hepatic sensitivity for alcohol likely play into the risk of development of cirrhosis. In patients with concomitant liver diseases, a synergistic effect on fibrosis ...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Tobacco and alcohol as risk factors for pancreatic cancer
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Murray Korc, Christie Y. Jeon, Mouad Edderkaoui, Stephen J. Pandol, Maxim S. Petrov, on behalf of the Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC)AbstractPancreatic cancer is projected to become the leading cause of cancer deaths by 2050. The risk for pancreatic cancer may be reduced by up to 27% by modifying lifestyle risk factors, most notably tobacco smoking. Based on analysis of more than 2 million unselected individuals from general population, this article...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Alcohol, smoking and benign hepato-biliary disease
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Daniel Mønsted Shabanzadeh, Srdan NovovicAbstractGallstone disease and pancreatitis are the most frequent benign hepato-biliary causes of hospital admissions. Gallstone disease is prevalent, but symptomatic disease develops only in about one out of five carriers. Alcohol intake seems to protect gallstone formation in cohort studies possibly through effects on bile cholesterol metabolism, the enterohepatic circulation, and gallbladder function. The impact of smoking on gallstone formation seems minor. Both...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Alcohol, smoking and risk of oesophago-gastric cancer
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Jing Dong, Aaron P. ThriftAbstractOesophago-gastric cancers (oesophageal and gastric cancers) are common, highly fatal cancers. Oesophageal squamous cell carcinoma (OSCC) and oesophageal adenocarcinoma (OAC) are the two main histological subtypes of oesophageal cancer. Globally, OSCC remains the most common histological subtype of oesophageal cancer, with the highest burden occurring along two geographic belts, one from north central China through the central Asian republics to northern Iran, and one from ...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Tobacco smoking, alcohol consumption and gastro-oesophageal reflux disease
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Eivind Ness-Jensen, Jesper LagergrenAbstractGastro-oesophageal reflux disease (GORD) develops when reflux of gastric content causes troublesome symptoms or complications. The main symptoms are heartburn and acid regurgitation and complications include oesophagitis, strictures, Barrett's oesophagus and oesophageal adenocarcinoma. In addition to hereditary influence, GORD is associated with lifestyle factors, mainly obesity. Tobacco smoking is regarded as an aetiological factor of GORD, while alcohol consump...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Aims & Scope/ Editorial Board
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

The role of smoking and alcohol behaviour in management of functional gastrointestinal disorders
Publication date: October 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 5Author(s): Bodil OhlssonAbstractFunctional gastrointestinal disorders (FGIDs) are common disorders in the population. Lifestyle habits have been suspected to influence the presence and degree of symptoms, and many studies have examined the role of food components and physical activity on the disease development. The role of smoking and alcohol intake on FGID has been less thoroughly examined. This systematic literature review, of a large amount of studies from different countries around the world with different desig...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Intervening in disease through genetically-modified bacteria
Publication date: December 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 6Author(s): Adilson K. Ferreira, Lisley I. Mambelli, Saravanan Y. PillaiAbstractThe comprehension of the molecular basis of different diseases is rapidly being dissected as a consequence of advancing technology. Consequently, proteins with potential therapeutic usefulness, including cytokines and signaling molecules have been identified in the last decades. However, their clinical use is hampered by disadvantageous functional and economic considerations. One of the most important of these considerations is targeted t...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Preface to “Gut microbiome in health and disease”
Publication date: December 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 6Author(s): Maikel P. Peppelenbosch (Source: Best Practice and Research Clinical Gastroenterology)
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

The gastrointestinal microbiota and its role in oncogenesis
Publication date: December 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 6Author(s): S.Y. Lam, J. Yu, S.H. Wong, M.P. Peppelenbosch, G.M. FuhlerAbstractAdvances in research techniques have made it possible to map the microbial communities in the gastrointestinal (GI) tract, where the majority of bacteria in the human body reside. Disturbances in these communities are referred to as dysbiosis and have been associated with GI cancers. Although dysbiosis is observed in several GI malignancies, the specific role of these changes has not been understood to the extent of Helicobacter pylori (HP...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Microbiome measurement: Possibilities and pitfalls
Publication date: December 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 6Author(s): Djawad Radjabzadeh, André G. Uitterlinden, Robert KraaijAbstractMicrobiome research is an emerging field in medical sciences. Several studies have made headways in understanding the influence of microbes on our health and disease states. Further progress in mapping microbiome populations across different body sites and understanding the underlying mechanisms of microbiome-host interactions depends critically on study design, collection protocols, analytical genetic techniques, and reference databases. In...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Lifestyle alters GUT-bacteria function: Linking immune response and host
Publication date: December 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 6Author(s): Omid Jazayeri, S. Mojtaba Daghighi, Farhad RezaeeAbstractMicrobiota in human is a “mixture society” of different species (i.e. bacteria, viruses, funguses) populations with a different way of relationship classification to Human. Human GUT serves as the host of the majority of different bacterial populations (GUT flora, more than 500 species), which are with us (“from the beginning”) in an innate manner known as the commensal (no harm to each other) and symbiotic (mutual benefit) relationship. A h...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research

Action and function of Akkermansia muciniphila in microbiome ecology, health and disease
Publication date: December 2017Source: Best Practice & Research Clinical Gastroenterology, Volume 31, Issue 6Author(s): Noora Ottman, Sharon Y. Geerlings, Steven Aalvink, Willem M. de Vos, Clara BelzerAbstractThe discovery of Akkermansia muciniphila has opened new avenues for the use of this abundant intestinal symbiont in next generation therapeutic products, as well as targeting microbiota dynamics. A. muciniphila is known to colonize the mucosal layer of the human intestine where it triggers both host metabolic and immune responses. A. muciniphila is particularly effective in increasing mucus thickness and increasing ...
Source: Best Practice and Research Clinical Gastroenterology - July 5, 2018 Category: Gastroenterology Source Type: research