Best Practice and Research. Clinical Endocrinology and Metabolism Best Practice and Research. Clinical Endocrinology and Metabolism RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Surgical Management of the Compromised Recurrent Laryngeal Nerve in Thyroid Cancer
Publication date: Available online 4 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Marika D. Russell, Dipti Kamani, Gregory W. RandolphAbstractSurgical management of thyroid cancer requires careful consideration of the recurrent laryngeal nerve and its impact on glottic function. Management of the compromised recurrent laryngeal nerve is a complex task, requiring synthesis of multiple elements. The surgeon must have an appreciation for preoperative recurrent laryngeal nerve function, intraoperative anatomic and electromyographic information, disease characteristics, and relevant pa...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 4, 2019 Category: Endocrinology Source Type: research

Risk-Oriented Concept of Treatment for Intrathyroid Papillary Thyroid Cancer
Publication date: Available online 4 June 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Dana M. Hartl, Julien Hadoux, Joanne Guerlain, Ingrid Breuskin, Fabienne Haroun, Sophie Bidault, Sophie Leboulleux, Livia LamartinaAbstractAdapting treatment and follow-up according to the risk of recurrence and/or death from thyroid cancer is a relatively recent concept of “personnalized” medicine, developed particularly to avoid overtreatment of low-risk thyroid cancer which represents the majority of thyroid cancers diagnosed in the world today. For low-risk thyroid cancer, this decrease in ex...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - June 4, 2019 Category: Endocrinology Source Type: research

Modern neuro-ophthalmological evaluation of patients with pituitary disorders
Publication date: Available online 30 May 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Anne-Laure Vié, Gérald RaverotAbstractPituitary adenomas can manifest as ophthalmological symptoms, such as decreased vision, impaired visual field or diplopia. It is important to recognize these neuro-ophthalmological syndromes to achieve early diagnosis and treatment and to improve prognosis. Currently, ophthalmological examination includes precise measuring instruments, such as optical coherence tomography (OCT), which allows the evaluation of optic atrophy related to compression of the anterior...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - May 31, 2019 Category: Endocrinology Source Type: research

Modern Imaging of Pituitary Adenomas
This article reviews current recommendations for imaging of PA, examines the potential added value that alternative MR sequences and/or CT can offer, and considers how the use of functional/molecular imaging might allow definitive treatment to be recommended for a subset of patients who would otherwise be deemed unsuitable for (further) surgery and/or RT. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - May 29, 2019 Category: Endocrinology Source Type: research

Prevention of pre-eclampsia after infertility treatment: Preconceptional minimalisation of risk factors
Publication date: Available online 15 May 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Hanna Hürter, Shane Vontelin van Breda, Lenka Vokalova, Marlene Brandl, Marc Baumann, Irene Hösli, Evelin Annegret Huhn, Christian De Geyter, Simona W. Rossi, Olav LapaireAbstractAlthough an increased risk of pre-eclampsia in pregnancies conceived after infertility treatment has been reported, it remains unknown whether preconceptional minimalisation of known risk factors would help in preventing pre-eclamsia. Obesity and preconceptional blood pressure are discussed as major risks for the developme...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - May 15, 2019 Category: Endocrinology Source Type: research

Therapeutic options after surgical failure in Cushing's disease: A critical review
Publication date: Available online 16 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): German Rubinstein, Andrea Osswald, Stephanie Zopp, Katrin Ritzel, Marily Theodoropoulou, Felix Beuschlein, Martin ReinckeCushing's disease (CD) is the most common etiology of Cushing's syndrome (CD) due to corticotroph pituitary adenoma, which are in most cases small (80–90% microadenomas) and in about 40% cannot be visualized on imaging of the sella. First-line treatment for CD is transsphenoidal surgery (TSS) with the aim of complete adenoma removal and preservation of pituitary gland function....
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 27, 2019 Category: Endocrinology Source Type: research

New Causes of Hypophysitis
Publication date: Available online 26 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Kevin C.J. Yuen, Vera Popovic, Peter J. TrainerAbstractHypophysitis is a rare entity characterized by inflammation of the pituitary gland and its stalk that can cause hypopituitarism and/or mass effect. Etiology can be categorized as primary or secondary to systemic disease, but may also be classified according to anatomical and hispathological criteria. Newly recognized causes of hypophysits have been recently described, mainly secondary to immunomodulatory medications and IgG4-related disease. Di...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 27, 2019 Category: Endocrinology Source Type: research

Pubertal Abnormalities In Adolescents with Chronic Disease
Publication date: Available online 19 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): K.T. Kao, M. Denker, M. Zacharin, S.C. WongAbstractPubertal disorders in the context of chronic disease especially in those with chronic inflammatory disorders or those requiring prolonged periods of treatment with glucocorticoid are common reasons for referral to the paediatric endocrine clinic. Disorders of puberty are also common in adolescents with disability requiring management by paediatric endocrinologists. In these adolescents, impaired skeletal development is also observed and this can be...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 20, 2019 Category: Endocrinology Source Type: research

Therapeutic options after surgical failure in Cushing’s disease: a critical review
Publication date: Available online 16 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): German Rubinstein, Andrea Osswald, Stephanie Zopp, Katrin Ritzel, Marily Theodoropoulou, Felix Beuschlein, Martin ReinckeAbstractCONTEXT:Cushing’s disease (CD) is the most common etiology of Cushing’s syndrome (CD) due to corticotroph pituitary adenoma, which are in most cases small (80-90% microadenomas) and in about 40% cannot be visualized on imaging of the sella. First-line treatment for CD is transsphenoidal surgery (TSS) with the aim of complete adenoma removal and preservation of pituitr...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 18, 2019 Category: Endocrinology Source Type: research

The risk/benefit ratio of radiotherapy in pituitary tumors
Publication date: Available online 16 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Giuseppe Minniti, John FlickingerAbstractRadiation therapy (RT) is an effective treatment for patients with either nonfunctioning or secreting pituitary adenomas unsuccessfully treated by surgery and/or medical therapy, resulting in local control of 90-95% at 5-10 years and variable normalization of hormonal hypersecretion for patients with GH-, ACTH-, and prolactin-secreting adenomas in the range of 40 to 80% at 5 years; however, its use has been limited because of concerns regarding potential lat...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 18, 2019 Category: Endocrinology Source Type: research

Long-Term Outcome after DNA-Based Prophylactic Neck Surgery in Children at Risk of Hereditary Medullary Thyroid Cancer
Publication date: Available online 17 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Andreas Machens, Henning DralleAbstractAdvances in sequencing technology, providing unprecedented insights into cancer progression, have shifted the treatment paradigm towards precision medicine for hereditary medullary thyroid cancer (MTC), away from the ‘one-size-fits-all’ approach predicated on genetic risk alone.The DNA-based/biochemical concept, factoring serum calcitonin into the benefit-risk equation, optimizes biochemical cure while minimizing extent of prophylactic surgery and operativ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 18, 2019 Category: Endocrinology Source Type: research

Puberty: Normal physiology (brief overview)
Publication date: Available online 30 March 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Claire L. Wood, Laura C. Lane, Tim CheethamPuberty is a defining phase of human development where growth ends and the ability to reproduce begins. An understanding of the events leading up to puberty highlights the fact that this is the culmination of a process of skeletal and gonadal activity that has been ongoing since conception. Although there is natural variation in the timing of events in and around puberty the basic underlying processes are common to all healthy human beings. This chapter is...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 16, 2019 Category: Endocrinology Source Type: research

Management of pituitary incidentaloma
Publication date: Available online 13 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Cesar Luiz Boguszewski, Nina Rosa de Castro Musolino, Leandro KasukiAbstractPituitary incidentalomas (PIs) represent a modern clinical entity increasingly recognized due to advances and easier accessibility to imaging techniques. By definition, PIs should be detected during brain imaging performed for investigation of a non-pituitary disease. Although anatomic variations, technical artefacts or pituitary hyperplasia might also be interpreted as PIs, the most relevant incidentally detected lesions a...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 14, 2019 Category: Endocrinology Source Type: research

Polycystic Ovary Syndrome in Adolescents
Publication date: Available online 13 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Preeti DabadghaoAbstractMenstrual irregularity and evidence of hyperandrogenism are characteristic features of polycystic ovary syndrome (PCOS) in adolescents. Diagnosis of PCOS is challenging as clinical features cannot be differentiated from the events of normal development. The specific aetiology of PCOS is not known but it is a complex disease resulting from interplay of genetic susceptibility, intrauterine, extra-uterine and environmental factors. Obesity and insulin resistance are common asso...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 14, 2019 Category: Endocrinology Source Type: research

Update on the genetics of differences of sex development (DSD)
Publication date: Available online 13 April 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Dorien Baetens, Hannah Verdin, Elfride De Baere, Martine CoolsAbstractHuman gonadal development is regulated by the temporospatial expression of many different genes with critical dosage effects. Subsequent sex steroid hormone production requires several consecutive enzymatic steps and functional hormone receptors. Disruption of this complex process can result in atypical sex development and lead to conditions referred to as differences (disorders) of sex development (DSD). With the advent of massi...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - April 14, 2019 Category: Endocrinology Source Type: research