Best Practice and Research. Clinical Endocrinology and Metabolism Best Practice and Research. Clinical Endocrinology and Metabolism RSS feedThis is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Autoimmune Polyglandular Diseases
Publication date: Available online 4 October 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): George J. Kahaly, Lara FrommerAbstractAutoimmune polyglandular diseases (APD) are defined as the presence of two autoimmune –induced endocrine failures. With respect to the significant morbidity and potential mortality of APD, the diagnostic objective is to detect APD at an early stage, with the advantage of less frequent complications, effective therapy and better prognosis. This requires that patients at risk be regularly screened for subclinical endocrinopathies prior to clinical manifestatio...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - October 5, 2019 Category: Endocrinology Source Type: research

Modern endocrine surgery – striving for a better quality of life
Publication date: Available online 28 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Henning Dralle, Frank Weber (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 29, 2019 Category: Endocrinology Source Type: research

Value of ileus-prophylactic surgery for metastatic neuroendocrine midgut tumours
Publication date: Available online 25 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Frank Weber, Henning DralleAbstractNeuroendocrine tumours of the small intestine (SINET) are a rare disease. However, a rising incidence rate and excellent long-term survival, even in the setting of metastatic disease lead to a high prevalence of SINET of up to 11/100.000. At the time of diagnosis, most patients already suffer from metastatic disease.About one third of patients demonstrate localized or regional metastatic disease at time of presentation. For those patients the indication for cu...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 26, 2019 Category: Endocrinology Source Type: research

Editorial Board
Publication date: April 2019Source: Best Practice & Research Clinical Endocrinology & Metabolism, Volume 33, Issue 2Author(s): (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 25, 2019 Category: Endocrinology Source Type: research

The epidemiology, diagnosis and treatment of Prolactinomas: The old and the new
Publication date: April 2019Source: Best Practice & Research Clinical Endocrinology & Metabolism, Volume 33, Issue 2Author(s): Philippe Chanson, Dominique MaiterPrevalence and incidence of prolactinomas are approximately 50 per 100,000 and 3–5 new cases/100,000/year. The pathophysiological mechanism of hyperprolactinemia-induced gonadotropic failure involves kisspeptin neurons. Prolactinomas in males are larger, more invasive and less sensitive to dopamine agonists (DAs). Macroprolactin, responsible for pseudohyperprolactinemia is a frequent pitfall of prolactin assay.DAs still represent the primary therapy for most prol...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 25, 2019 Category: Endocrinology Source Type: research

Autoimmune diseases and pregnancy
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Angela Tincani, Cecilia Nalli, Jamilya Khizroeva, Victoria Bitsadze, Andrea Lojacono, Laura Andreoli, Yehuda Shoenfeld, Alexander MakatsariyaPregnancy in autoimmune diseases remains an argument of debate. In last years great improvements were done and with the correct medical support women with disease such as Systemic Lupus Erythematosus or Antiphospholipid Syndrome can afford a pregnancy and have healthy babies. The starting point is a good counselling. Women should be informed about risks th...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 19, 2019 Category: Endocrinology Source Type: research

Insights into the autoimmune aspect of premature ovarian insufficiency
Publication date: Available online 16 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Kassem Sharif, Abdulla Watad, Charlie Bridgewood, Darja Kanduc, Howard Amital, Yehuda ShoenfeldAbstractPremature ovarian insufficiency (POI) refers to a continuum of decreasing ovarian function in women before the age of 40. To date, the cause of POI in the majority of cases remain unresolved. Many cases has been linked to genetic, toxic, infections, enzymatic and iatrogenic causes.A key function of the immune system is to identify and differentiate “self” and “non self” i.e. tolerance....
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 17, 2019 Category: Endocrinology Source Type: research

Treatment of patients with Graves' disease and the appropriate extent of thyroidectomy
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Iuliana D. Bobanga, Christopher R. McHenryGraves' disease is an autoimmune disorder caused by thyroid stimulating auto-antibodies directed against the thyrotropin receptor on thyroid follicular cells. It is the most common cause of hyperthyroidism and is associated with cardiovascular, ophthalmologic and other systemic manifestations. Three treatment options are available for Graves' disease: anti-thyroid drugs, radioactive iodine and thyroidectomy. While thyroidectomy is the least common option u...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 15, 2019 Category: Endocrinology Source Type: research

Prolactin and autoimmunity: the hormone as an inflammatory cytokine
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Vânia Vieira Borba, Gisele Zandman-Goddard, Yehuda ShoenfeldAbstractNowadays, more than 80 autoimmune disorders are recognized, in which an aberrant immune response against different organs and tissues plays a crucial role. Hormonal homeostasis has great influence in achieving competent and healthy immune system function. Prolactin has a bioactive function acting as a hormone and a cytokine. It influences the immune system modulation, mainly inhibiting the negative selection of autoreactive B ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research

“Autoimmune Diseases and Pregnancy”
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Angela Tincani, Cecilia Nalli, Jamilya Khizroeva, Victoria Bitsadze, Andrea Lojacono, Laura Andreoli, Yehuda Shoenfeld, Alexander MakatsariyaAbstractPregnancy in autoimmune diseases remains an argument of debate. In last years great improvements were done and with the correct medical support women with disease such as Systemic Lupus Erythematosus or Antiphospholipid Syndrome can afford a pregnancy and have healthy babies. The starting point is a good counselling. Women should be informed about ...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research

Exacerbations of autoimmune diseases during pregnancy and postpartum
Publication date: Available online 11 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Vânia Vieira Borba, Gisele Zandman-Goddard, Yehuda ShoenfeldAbstractAutoimmune diseases represent a complex heterogeneous group of disorders that occur as a results of immune homeostasis dysregulation and loss of self-tolerance. Interestingly, more than 80% of the cases are found among women at reproductive age. Normal pregnancy is associated with remarkable changes in the immune and endocrine signaling required to tolerate and support the development and survival of the placenta and the semi-...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 11, 2019 Category: Endocrinology Source Type: research

Universal Screening For Thyroid Disease During Pregnancy Should Be Performed
Publication date: Available online 6 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Alex Stagnaro-Green, Allan Dong, Mary D. StephensonAbstractThyroid disease can significantly impact the pregnant woman and her child. Human and animal studies have firmly linked overt hypothyroidism and overt hyperthyroidism to miscarriage, preterm delivery and other adverse pregnancy outcomes. Overt hypothyroidism and overt hyperthyroidism affect 1% of all pregnancies. Treatment is widely available, and if detected early, results in decreased rates of adverse outcomes. Universal screening for t...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 6, 2019 Category: Endocrinology Source Type: research

Constitutional delay of puberty versus congenital hypogonadotropic hypogonadism: genetics, management and updates
Publication date: Available online 5 September 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Taneli Raivio, Päivi J. MiettinenAbstractDelayed puberty (DP) affects approximately 2% of adolescents. In the vast majority of patients in both sexes, it is due to constitutional delay of growth and puberty (CDGP), a self-limited condition in which puberty starts later than usual but progresses normally. However, some CDGP patients may benefit from medical intervention with low-dose sex steroids or peroral aromatase inhibitor letrozole (only for boys). Other causes of DP include permanent hypog...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 5, 2019 Category: Endocrinology Source Type: research

Management of disorders of sex development – With a focus on development of the child and adolescent through the pubertal years
This articles will discuss clinical and genetic diagnosis, decisions regarding sex of rearing, ethical dilemmas, medical management of the infant and of the child or adolescent presenting for the first time with a DSD. Surgical options, timing and management are outlined. (Source: Best Practice and Research Clinical Endocrinology and Metabolism)
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 4, 2019 Category: Endocrinology Source Type: research

Contemporary surgical management of the Zollinger-Ellison syndrome in Multiple Endocrine Neoplasia type 1
Publication date: Available online 31 August 2019Source: Best Practice & Research Clinical Endocrinology & MetabolismAuthor(s): Max B. Albers, Jerena Manoharan, Detlef K. BartschAbstractAbout 30% of patients with MEN1 develop a Zollinger-Ellison syndrome. Meanwhile it is well established that the causative gastrinomas are almost exclusively localized in the duodenum and not in the pancreas, MEN1 gastrinomas occur multicentric and are associated with hyperplastic gastrin cell lesions and tiny gastrin-producing micro tumors in contrast to sporadic duodenal gastrinomas. Regardless of the high prevalence of early lymphatic met...
Source: Best Practice and Research Clinical Endocrinology and Metabolism - September 2, 2019 Category: Endocrinology Source Type: research