A systematic review on the genetics of male infertility in the era of next-generation sequencing
ConclusionsMale infertility is a condition that is genetically heterogeneous, and therefore remarkably amenable to study by NGS. Although some headway has been made, given the high incidence of this condition despite its detrimental effect on reproductive fitness, there is significant potential for further discoveries. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
A systematic review on sperm DNA fragmentation in male factor infertility: Laboratory assessment
ConclusionThere are pros and cons to all the available SDF assays. TUNEL is a reliable technique with greater accuracy and as an additional diagnostic test in Andrology laboratories along with basic semen analysis can predict fertility outcome, and thus direct the choice of an assisted reproductive technology procedure for infertile couples. Also, the TUNEL assay can be used as a prognostic test and results are beneficial in deciding personalised treatment for infertile men. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Laboratory assessment of oxidative stress in semen
ConclusionTraditional OS laboratory assessments have their limitations. Amongst the prevalent laboratory techniques, ORP is novel and better option as it can be easily used in a clinical setting to provide a comprehensive review of OS. However, more studies are needed to evaluate its reproducibility across various laboratory centres. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Oxidation–reduction potential and sperm DNA fragmentation, and their associations with sperm morphological anomalies amongst fertile and infertile men
ConclusionA direct inverse relationship exists between seminal ORP and SDF with various levels of normal sperm morphology. Using ORP and SDF measures in conjunction with standard semen morphology analysis could validate the result of the fertility status of patients. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Prediction of male infertility by the World Health Organization laboratory manual for assessment of semen analysis: A systematic review
ConclusionsImpaired semen parameters alone cannot be used to predict fertility as these men still have a chance of being fertile, except when a man has azoospermia, necrospermia or globozoospermia. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Update on the proteomics of male infertility: A systematic review
ConclusionIn this molecular era, sperm proteomics has created a platform for enhanced understanding of male reproductive physiology as a potential tool for identification of novel protein biomarkers related to sperm function in infertile men. Therefore, it is believed that proteomic biomarkers can overcome the gaps in information from conventional semen analysis that are of limited clinical utility. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Systematic review of antioxidant types and doses in male infertility: Benefits on semen parameters, advanced sperm function, assisted reproduction and live-birth rate
ConclusionAntioxidants generally have a favourable effect on male fertility. Further studies are needed to identify the optimal antioxidant regimen that can be used safely and efficiently in clinical practice. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Advances in sperm retrieval techniques in azoospermic men: A systematic review
ConclusionMicro-TESE is the most efficient method for retrieving sperm but requires special expertise and can be traumatic for the testes. Conventional biopsies are twice more likely to retrieve sperm than fine-needle aspiration. Testicular aspiration performed by multiple passes into the testis is traumatic and is not efficient for sperm retrieval. Needle-aspiration biopsy and open real-time testicular mapping by the single seminiferous tubule technique can offer less traumatic methods for sperm retrieval, which can be tried before proceeding to micro-TESE. The first attempt at sperm retrieval is the best chance the patie...
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Chromosomal abnormalities in infertile men with azoospermia and severe oligozoospermia in Qatar and their association with sperm retrieval intracytoplasmic sperm injection outcomes
ConclusionThe incidence of chromosomal abnormalities in Qatar as a cause of severe male infertility is within a similar range as their prevalence internationally. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Systematic review of hormone replacement therapy in the infertile man
ConclusionsExogenous testosterone inhibits spermatogenesis. Hypogonadal men wanting to preserve their fertility and at the same time benefiting from TRT effects can be prescribed selective oestrogen receptor modulators or testosterone plus low-dose human chorionic gonadotrophin (hCG). Patients treated for infertility with hypogonadotrophic hypogonadism can be prescribed hCG alone at first followed by or in combination from the start with follicle-stimulating hormone preparations. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Review of the role of robotic surgery in male infertility
ConclusionsRobotic assistance for microsurgical procedures in male infertility appears to be safe and feasible. It has several advantages including elimination of tremor, multi-view magnification, additional instrument arms, and enhanced dexterity with articulating instrument arms. It also has a short learning curve with a small skin incision. However, larger, prospective studies are needed to establish the clinical benefits over standard microsurgery. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Varicocele management for infertility and pain: A systematic review
Publication date: March 2018Source: Arab Journal of Urology, Volume 16, Issue 1Author(s): Scott D. Lundy, Edmund S. SabaneghAbstractDespite being first described two thousand years ago, the varicocele remains a controversial multifaceted disease process with numerous biological consequences including infertility, hypogonadism, and chronic orchidalgia. The underlying mechanisms remain poorly understood and likely include hypoxia, oxidative stress, hyperthermia, anatomical aberrations, and genetics as primary components. Despite a high prevalence amongst asymptomatic fertile men, varicoceles paradoxically also represent the ...
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Spermatogonial stem cell transplantation and male infertility: Current status and future directions
ConclusionsEvidence does not yet support clinical application of SSCs in humans. However, significant progress in the in vitro and in vivo development of SSCs, including differentiation into functional germ cells, gives reason for cautious optimism for future research. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Microscopic subinguinal varicocelectomy in 100 consecutive cases: Spermatic cord vascular anatomy, recurrence and hydrocele outcome analysis
ConclusionMicroscopic subinguinal varicocelectomy accurately evaluated the detailed vascular anatomy of the spermatic cord, achieving excellent surgical outcome with minimal varicocele recurrence and hydrocele formation. Microscopic subinguinal varicocelectomy should be the ‘gold standard’ for varicocelectomy. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
Role of varicocele treatment in assisted reproductive technologies
ConclusionVaricocele repair is a cost-effective treatment method that can improve semen parameters, pregnancy rates, and live-birth rates in most infertile men with clinical varicocele. By improving semen parameters and sperm structure, varicocele repair can decrease or even eliminate ART requirement. (Source: Arab Journal of Urology)
Source: Arab Journal of Urology - July 10, 2018 Category: Urology & Nephrology Source Type: research
