Neurogenomics: challenges and opportunities for Ghana
Publication date: Available online 21 June 2015 Source:Applied & Translational Genomics Author(s): Thomas K. Karikari , Emmanuel Quansah (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - June 22, 2015 Category: Genetics & Stem Cells Source Type: research
NDUFA12L mitochondrial complex-I assembly factor: Implications for taupathies
Publication date: Available online 18 June 2015 Source:Applied & Translational Genomics Author(s): Mohamed Salama , Wael M.Y. Mohamed There is a strong correlation between taupathies and the development and progression of neurodegenerative disorders. Abnormal tau becomes hyperphosphorylated and dissociated from microtubules with the aggregation of intracellular tau aggregates within the patient's brain. The current review is divided into two broad sections. In the first section we discuss the molecular biology and the clinicopathologic features of taupathies. While in the second section we discuss the relatio...
Source: Applied and Translational Genomics - June 21, 2015 Category: Genetics & Stem Cells Source Type: research
Investigation of redox status in chronic cerebral hypoperfusion-induced neurodegeneration in rats
Publication date: Available online 20 June 2015 Source:Applied & Translational Genomics Author(s): Anil Kumar Saxena , Saif Saad Abdulmajeed , Sunil Gurtu , Wael M.Y. Mohamed Aging related reduction in cerebral blood flow (CBF) has been linked with neurodegenerative disorders including Alzheimer's disease and dementia. Experimentally, a condition of chronic cerebral hypoperfusion due to reduced CBF can be induced by permanent bilateral occlusion of common carotid arteries (2-vessel occlusion, 2VO) in rats. Since oxidative stress, leading to neuronal apoptosis and death, is one of the mechanisms, which is th...
Source: Applied and Translational Genomics - June 21, 2015 Category: Genetics & Stem Cells Source Type: research
NDUFA12L mitochondrial complex-I assembly factor: Implications for tauopathies
Publication date: Available online 18 June 2015 Source:Applied & Translational Genomics Author(s): Mohamed Salama , Wael M.Y. Mohamed There is a strong correlation between taupathies and the development and progression of neurodegenerative disorders. Abnormal tau becomes hyperphosphorylated and dissociated from microtubules with the aggregation of intracellular tau aggregates within the patient's brain. The current review is divided into two broad sections. In the first section we discuss the molecular biology and the clinicopathologic features of taupathies. While in the second section we discuss the relatio...
Source: Applied and Translational Genomics - June 19, 2015 Category: Genetics & Stem Cells Source Type: research
Risperidone-associated adverse drug reactions and CYP2D6 polymorphisms in a South African cohort
Conclusion CYP2D6 variation appeared not to be a good pharmacogenetic marker for predicting risperidone-related ADRs in this naturalistic South African cohort. Evaluation of a larger cohort would be needed to confirm these observations, including an examination of the role of potential intermediaries between the hypothesised genetic and clinical phenotypes. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - May 15, 2015 Category: Genetics & Stem Cells Source Type: research
Neurogenethics: An emerging discipline at the intersection of ethics, neuroscience, and genomics
Publication date: Available online 15 May 2015 Source:Applied & Translational Genomics Author(s): Turhan Canli The analysis of ethical, legal, and social implications (ELSI) associated with genetics (“genethics”) has focused on traditional concerns in bioethics, such as privacy and informed consent. The analysis of ELSI associated with neuroscience (“neuroethics”) has focused on issues related to personhood etc. With neurogenomics coming of age, this is an appropriate time to attend to the set of novel concerns that arises when we consider the confluence of these two lines of research. I call this area...
Source: Applied and Translational Genomics - May 15, 2015 Category: Genetics & Stem Cells Source Type: research
Drought and drought with triazoles induced changes on pigment composition and biochemical constituents of Zea mays L. (Maize)
Publication date: Available online 14 April 2015 Source:Applied & Translational Genomics Author(s): Mahalingam Rajasekar , Paramasivam Manivannan In the present study pot culture experiment was conducted to estimate the ameliorating effect of triazoles, namely triadimefon (TDM), paclobutrazol (PBZ) and hexaconazole (HEX) on drought stress, pigment composition and biochemical constituents of Zea mays L. (Maize) belongs to the family poaceae. From 30days after sowing (DAS), the plants were subjected to 4days interval drought (DID) stress and drought stress with TDM at 15mgl−1, PBZ at 15mgl−1 and HEX at 10mg...
Source: Applied and Translational Genomics - May 11, 2015 Category: Genetics & Stem Cells Source Type: research
Neurogenomics: An Egyptian Perspective
Publication date: Available online 5 May 2015 Source:Applied & Translational Genomics Author(s): Wael M.Y. Mohamed (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - May 11, 2015 Category: Genetics & Stem Cells Source Type: research
Exercise Intensity Modulates Capillary Perfusion in Correspondence with ACE I/D Modulated Serum Angiotensin II Levels
Publication date: Available online 27 March 2015 Source:Applied & Translational Genomics Author(s): Sander van Ginkel , Arnold de Haan , Jorn Woerdeman , Luc Vanhees , Erik Serné , Jos de Koning , Martin Flück During exercise the renin-angiotensin system is stimulated. We hypothesized that the increase in serum angiotensin II (AngII) levels after exercise is dependent on exercise intensity and duration and secondly that people with the ACE-II genotype will show a higher increase in AngII serum levels. We also assumed that perfusion of upper limbs is transiently reduced with maximal cycling exercise and...
Source: Applied and Translational Genomics - March 27, 2015 Category: Genetics & Stem Cells Source Type: research
The Clinical Validity and Utility of Combinatorial Pharmacogenomics: Enhancing Patient Outcomes
Publication date: Available online 24 March 2015 Source:Applied & Translational Genomics Author(s): Joachim Benitez , Michael R. Jablonski , Josiah D. Allen , Joel G. Winner Prescribing safe and effective medications is a challenge in psychiatry. While clinical use of pharmacogenomic testing for individual genes has provided some clinical benefit, it has largely failed to show clinical utility. However, pharmacogenomic testing that integrates relevant genetic variation from multiple loci for each medication has shown clinical validity, utility and cost savings in multiple clinical trials. While some challen...
Source: Applied and Translational Genomics - March 25, 2015 Category: Genetics & Stem Cells Source Type: research
Patients' views on incidental findings from clinical exome sequencing
This article characterizes the opinions of patients and family members of patients undergoing clinical genomic-based testing regarding the return of incidental findings from these tests. Over sixteen months, we conducted 55 in-depth interviews with individuals to explore their preferences regarding which types of results they would like returned to them. Responses indicate a diversity of attitudes toward the return of incidental findings and a diversity of justifications for those attitudes. The majority of participants also described an imperative to include the patient in deciding which results to return rather than havi...
Source: Applied and Translational Genomics - March 9, 2015 Category: Genetics & Stem Cells Source Type: research
Harnessing big data for precision medicine: A panel of experts elucidates the data challenges and proposes key strategic decisions points
This article reports the panel discussion. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - February 28, 2015 Category: Genetics & Stem Cells Source Type: research
Patients’ Views on Incidental Findings from Clinical Exome Sequencing
This article characterizes the opinions of patients and family members of patients undergoing clinical genomic-based testing regarding the return of incidental findings from these tests. Over sixteen months, we conducted 55 in-depth interviews with individuals to explore their preferences regarding which types of results they would like returned to them. Responses indicate a diversity of attitudes toward the return of incidental findings and a diversity of justifications for those attitudes. The majority of participants also described an imperative to include the patient in deciding which results to return rather than havi...
Source: Applied and Translational Genomics - February 21, 2015 Category: Genetics & Stem Cells Source Type: research
Nutrigenomics: A controversy
Publication date: Available online 14 February 2015 Source:Applied & Translational Genomics Author(s): Cristiana Pavlidis , George P. Patrinos , Theodora Katsila Nutrigenomics is an emerging science which investigates a certain area of nutrition that uses molecular tools to search access and understand the several responses obtained through a certain diet applied between individual or population groups. The increased need for the use of personalised nutrition in patients is increasing and research is being made on its possible effects. However, research on nutrigenomics and in particular, obesity is still on...
Source: Applied and Translational Genomics - February 14, 2015 Category: Genetics & Stem Cells Source Type: research
The lifestylisation of healthcare? ‘Consumer genomics’ and mobile health as technologies for healthy lifestyle
Publication date: Available online 7 February 2015 Source:Applied & Translational Genomics Author(s): Federica Lucivero , Barbara Prainsack Consumer genomics and mobile health provide health-related information to individuals and offer advice for lifestyle change. These ‘technologies for healthy lifestyle’ occupy an ambiguous space between the highly regulated medical domain and the less regulated consumer market. We argue that this ambiguity challenges implicit distinctions between what is medical and what is related to personal lifestyle choices within current regulatory systems. In this article, we dis...
Source: Applied and Translational Genomics - February 8, 2015 Category: Genetics & Stem Cells Source Type: research
