Ethics education for clinician–researchers in genetics: The combined approach
Publication date: Available online 16 December 2014 Source:Applied & Translational Genomics Author(s): Ma'n Zawati , Eliza Cohen , David Parry , Denise Avard , David Syncox Advancements in genomic technology and genetic research have uncovered new and unforeseen ethical and legal issues that must now be faced by clinician–researchers. However, lack of adequate ethical training places clinician–researchers in a position where they might be unable to effectively assess and resolve the issues presented to them. The literature demonstrates that ethics education is relevant and engaging where it is targeted...
Source: Applied and Translational Genomics - February 4, 2015 Category: Genetics & Stem Cells Source Type: research
Genetics, lifestyle and longevity: Lessons from centenarians
Publication date: Available online 4 February 2015 Source:Applied & Translational Genomics Author(s): Diddahally Govindaraju , Gil Atzmon , Nir Barzilai Longevity as a complex life-history trait shares an ontogenetic relationship with other quantitative traits and varies among individuals, families and populations. Heritability estimates of longevity suggest that about a third of the phenotypic variation associated with the trait is attributable to genetic factors, and the rest is influenced by epigenetic and environmental factors. Individuals react differently to the environments they are a part of, as well...
Source: Applied and Translational Genomics - February 4, 2015 Category: Genetics & Stem Cells Source Type: research
NGS meta data analysis for identification of SNP and INDEL patterns in human airway transcriptome: A preliminary indicator for lung cancer
This study is only a preliminary kind and more vigorous data analysis and wet lab validation are required. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - January 25, 2015 Category: Genetics & Stem Cells Source Type: research
Precision medicine is here, break out your wallet
Publication date: Available online 30 December 2014 Source:Applied & Translational Genomics Author(s): Nabil Hafez (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 31, 2014 Category: Genetics & Stem Cells Source Type: research
NGS Meta Data Analysis for Identification of SNPs and INDELs Pattern in Human Airway Transcriptome: A Preliminary Indicator for Lung Cancer
This study is only preliminary kind and more vigorous data analysis and wet lab validation is required. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 25, 2014 Category: Genetics & Stem Cells Source Type: research
Ethics Education for Clinician-Researchers in Genetics: The Combined Approach
Publication date: Available online 16 December 2014 Source:Applied & Translational Genomics Author(s): Ma’n Zawati , Eliza Cohen , David Parry , Denise Avard , David Syncox (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 17, 2014 Category: Genetics & Stem Cells Source Type: research
Challenges in global genomics education
Publication date: 1 December 2014 Source:Applied & Translational Genomics, Volume 3, Issue 4 Author(s): Ashwini de Abrew , Vajira H.W. Dissanayake , Bruce R. Korf In spite of high expectations for the integration of genomics into medicine, it is not clear that health providers are competent to appropriately use new genomic approaches. The issue is further complicated by differences across the globe in terms of educational systems, access to genomic technologies, and priorities in health care. In this commentary we will review some of the major challenges in educating the health provider workforce about genom...
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
Reciprocity and transparency: Normative principles of data sharing
Publication date: 1 December 2014 Source:Applied & Translational Genomics, Volume 3, Issue 4 Author(s): Carol Isaacson Barash (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
Open access and data sharing: Easier said than done
Publication date: 1 December 2014 Source:Applied & Translational Genomics, Volume 3, Issue 4 Author(s): Carol Isaacson Barash , Gholson Lyon (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
Open Steps: A journey to discover and document Open Knowledge projects around the globe
Publication date: 1 December 2014 Source:Applied & Translational Genomics, Volume 3, Issue 4 Author(s): Alex Corbi , Margo Thierry (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
What is translational genomics? An expanded research agenda for improving individual and population health
Publication date: 1 December 2014 Source:Applied & Translational Genomics, Volume 3, Issue 4 Author(s): Sheri D. Schully , Muin J. Khoury (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
Global genomic knowledge sharing — A call for affirmative action
Publication date: 1 December 2014 Source:Applied & Translational Genomics, Volume 3, Issue 4 Author(s): Barash Carol Isaacson Ph.D. (Source: Applied and Translational Genomics)
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
Partial KCNQ1OT1 hypomethylation: A disguised familial Beckwith–Wiedemann syndrome as a sporadic adrenocortical tumor
Publication date: 1 March 2015 Source:Applied & Translational Genomics, Volume 4 Author(s): Dorra H'mida Ben-Brahim , Sabeur Hammami , Marwa Haddaji Mastouri , Saoussen Trabelsi , Maroua Chourabi , Sihem Sassi , Soumaya Mougou , Moez Gribaa , Abdelfattah Zakhama , Mohamed Neji Guédiche , Ali Saad Beckwith–Wiedemann syndrome has a wide spectrum of complications such as embryonal tumors, namely adrenocortical tumor. Tumor predisposition is one of the most challenging manifestations of this syndrome. A 45-day old female with a family history of adrenocortical tumor presented with adrenocortical tumor...
Source: Applied and Translational Genomics - December 15, 2014 Category: Genetics & Stem Cells Source Type: research
Co-evolution of RNA polymerase with RbpA in the phylum Actinobacteria
Publication date: 1 December 2012 Source:Applied & Translational Genomics, Volume 1 Author(s): Abhinav Dey , V.R. Adithi , Dipankar Chatterji The role of RbpA in the backdrop of M. smegmatis showed that it rescues mycobacterial RNA polymerase from rifampicin-mediated inhibition (Dey et al., 2010; Dey et al., 2011). Paget and co-workers (Paget et al., 2001; Newell et al., 2006) have revealed that RbpA homologs occur exclusively in actinobacteria. Newell et al. (2006) showed that MtbRbpA, when complemented in a ∆rbpA mutant of S. coelicolor, showed a low recovery of MIC (from 0.75 to 2μg/ml) as compared to ...
Source: Applied and Translational Genomics - October 12, 2014 Category: Genetics & Stem Cells Source Type: research
A new method for non-invasive prenatal diagnosis of Down syndrome using MeDIP real time qPCR
Publication date: 1 December 2012 Source:Applied & Translational Genomics, Volume 1 Author(s): Philippos C. Patsalis During the last decade, the area of non-invasive prenatal diagnosis (NIPD) has rapidly evolved. Several methodological approaches have been presented and demonstrated a proof of concept for the NIPD of chromosomal aneuploidies. The two most promising methods are NIPD using next generation sequencing technologies and NIPD using Methylation DNA Immunoprecipitation (MeDIP) with real time qPCR. Both approaches have been validated with blind studies and have >99% accuracy. NIPD using next gene...
Source: Applied and Translational Genomics - October 12, 2014 Category: Genetics & Stem Cells Source Type: research
