Exercise Intensity Modulates Capillary Perfusion in Correspondence with ACE I/D Modulated Serum Angiotensin II Levels

Publication date: Available online 27 March 2015 Source:Applied & Translational Genomics Author(s): Sander van Ginkel , Arnold de Haan , Jorn Woerdeman , Luc Vanhees , Erik Serné , Jos de Koning , Martin Flück During exercise the renin-angiotensin system is stimulated. We hypothesized that the increase in serum angiotensin II (AngII) levels after exercise is dependent on exercise intensity and duration and secondly that people with the ACE-II genotype will show a higher increase in AngII serum levels. We also assumed that perfusion of upper limbs is transiently reduced with maximal cycling exercise and that subjects with the ACE-II compared to the ACE-ID/DD genotype will have a higher capillary perfusion due to lower AngII levels. Ten healthy subjects completed a maximal exercise test, a 12-minutes exercise test at ventilatory threshold and a 3-minutes test at the respiratory compensation point. AngII serum levels and capillary recruitment of the skin in the third finger was measured before and after exercise and breath-by-breath gas exchange during exercise was assessed. Baseline levels of AngII levels were lower prior to the 3-minutes test which took place on average 5 days after the last exercise. A two-fold increase compared to baseline levels was found for AngII only immediately after the 3-minutes test and not after the maximal exercise test and 12-minutes of exercise. Subjects without the I allele showed a decrease in AngII values after the maximal...
Source: Applied and Translational Genomics - Category: Genetics & Stem Cells Source Type: research