Selected papers from the 31st Annual Conference on Peritoneal Dialysis, February 20-22, 2011, Phoenix, Arizona.
Authors: PMID: 22220333 [PubMed - indexed for MEDLINE] (Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis)
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Stretch of human mesothelial cells increases cytokine expression.
Authors: He Z, Potter R, Li X, Flessner M Abstract Peritoneal dialysis requires large solution volumes that increase abdominal girth and stretch the mesothelial cells of the abdominal wall. To address the hypothesis that stretch stimulates those cells to increase synthesis and production of inflammatory cytokines, we grew MeT-5A human mesothelial cells to confluence and placed the cells in growth arrest on BioFlex Collagen membranes (Flexcell International Corporation, Hillsborough, NC, U.S.A.). After 48 hours, cells were either left stationary (STA) or cycled using a 3000T system (Flexcell International C...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Salt intake and hypervolemia in the development of hypertension in peritoneal dialysis patients.
Authors: Inal S, Erten Y, Akbulu G, Oneç K, Tek NA, Sahin G, Okyay GU, Sanlier N Abstract Peritoneal dialysis (PD) patients are often volume-expanded and have higher-than-normal blood pressure (BP) levels. In the present study, we aimed to investigate the role of fluid balance and salt intake for BP control in our PD patients. The study included 37 patients undergoing PD and having complete data for 3 consecutive months. Patients were allocated to one of two groups based on measured BP in the preceding 3 months: hypertensive patients (BP > 140/90 mmHg) and normotensive patients (did not meet the hypert...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Determinants of sodium removal with tidal automated peritoneal dialysis.
Authors: Domenici A, Scabbia L, Sivo F, Falcone C, Punzo G, Menè P Abstract In a comprehensive evaluation of dialysis adequacy, major attention has been recently paid to fluid and Na balance. Removal of Na has been reported to be significantly poorer with automated peritoneal dialysis (APD) than with continuous ambulatory peritoneal dialysis. Only limited data on Na removal with tidal APD have been published. We analyzed peritoneal Na mass balance in 122 separate nightly tidal APD sessions performed by 7 peritonitis-free, clinically stable, patients with negligible residual renal function (< 100 mL uri...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Influence of prednisolone on glucose and uric acid transport across peritoneal membrane in vitro.
Authors: Grzelak T, Czyzewska-Majchrzak L, Kramkowska M, Wojciechowska K, Szary B, Witmanowski H, Czyzewska K Abstract Prednisolone and other glucocorticosteroids are used by some peritoneal dialysis patients because of underlying diseases such as peritonitis. Although corticosteroids are potent inhibitors of various processes during inflammation, their influence on the transport properties of peritoneum is little known. Our study investigated the influence of prednisolone (0.001 g/dL) on glucose (1.8 g/dL) and uric acid (0.02 g/dL) transfer across isolated parietal peritoneum taken from the anterior abdom...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

A two-hit approach in the development of an experimental peritoneal sclerosis model.
Authors: Vlijm A, Sampimon DE, de Graaff M, Struijk DG, Krediet RT Abstract Models of encapsulating peritoneal sclerosis (EPS) are often based on local administration of chemical irritants. Our aim was to develop a clinically relevant "two-hit" model with incorporation of renal failure and exposure to conventional dialysis solutions. We randomly allocated 36 male Wistar rats that had undergone catheter implantation and a 70% nephrectomy to 3 peritoneal infusion groups. The experimental group was exposed to a 3.86% glucose-based conventional dialysis solution for 8 weeks, after which the animals received a ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Increase in serum creatinine in a patient on continuous peritoneal dialysis: potential mechanisms and management.
Authors: Xu Z, Gabaldon D, Wiggins B, Rondon-Berrios H, VanderJagt DJ, Tzamaloukas AH Abstract A large elevation in serum creatinine (S(Cr)) on an unchanged peritoneal dialysis (PD) schedule is usually caused by a decrease in total creatinine clearance (C(Cr)), but may also reflect an increase in creatinine (Cr) production. A meticulously compliant 43-year-old man with lupus nephritis on automated nocturnal PD plus an additional daytime exchange developed a rise in S(Cr) to 16.73 mg/dL from 8.06 mg/dL after starting fenofibrate, while total C(Cr) decreased only to 61.5 L/1.73 m2 from 77.4 m2 weekly. Creati...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Novel ways to preserve the peritoneal membrane.
Authors: Sajwani SH, Bargman JM Abstract The underlying pathophysiology that leads to morphologic and functional changes in the peritoneal membrane over time among patients on peritoneal dialysis is not well understood. Many studies have been conducted to try to abrogate those changes and so preserve peritoneal function. Conventional interventions that attempt to accomplish that end include prevention of peritonitis, timely removal of the peritoneal catheter in the face of non-resolving peritonitis, use of biocompatible dialysate, and limitation of total glucose exposure by avoiding hypertonic dextrose sol...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Continuous ambulatory peritoneal dialysis versus automated peritoneal dialysis and peritonitis in the short and very long term at risk.
Authors: Barone RJ, Cámpora MI, Gimenez NS, Ramirez L, Panese SA, Santopietro M Abstract Peritonitis (P) is the most important infectious complication in peritoneal dialysis (PD), but disagreement remains about the impact of PD modality on the frequency of P episodes. We compared indices linked to P between patients on continuous ambulatory PD (CAPD) and those on automated PD (APD) in the short and very long term. The study included 9 prevalent and 72 incident patients on CAPD (twin-bag system) and 37 incident patients on APD from 4 August 1995 to 31 March 2011. Data were collected prospectively from our ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Aging is an important risk factor for peritoneal dialysis-associated peritonitis.
Authors: Okayama M, Inoue T, Nodaira Y, Kimura Y, Nobe K, Seto T, Sueyoshi K, Takane H, Takenaka T, Okada H, Suzuki H Abstract Peritonitis remains a leading complication of peritoneal dialysis (PD). The aim of this observational retrospective cohort study, conducted at our single center, was to determine the risk factors for peritonitis. A Cox proportional hazards model was used for the multivariate analysis. The event investigated was peritonitis, and the variables studied were sex, age, diabetes mellitus, use of statins, and several laboratory values including albumin and total cholesterol. All PD patien...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Cardiovascular mortality in dialysis patients.
Authors: Al-Dadah A, Omran J, Nusair MB, Dellsperger KC Abstract In their broad spectrum, cardiovascular diseases are, collectively, the major cause of death in patients on dialysis. The population of patients treated with peritoneal dialysis and hemodialysis are not only subject to the traditional risk factors for heart disease, but also to certain uremia-associated risk factors that are unique in this population. In the dialysis population, data regarding the effectiveness of routine pharmacologic and procedural interventions on cardiovascular outcomes are limited. Most dialysis patients are excluded fro...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Peritoneal dialysis technique success during the initial 90 days of therapy.
Authors: Guest S, Hayes AC, Story K, Davis ID Abstract Comparisons of technique success by peritoneal dialysis (PD) modality have typically excluded the initial 90 days of therapy. We analyzed a database of 51,469 new PD starts from 2004 to 2008 in the United States. The analysis concentrated on the initial 90 days of therapy to determine technique success and the impact of the continuous ambulatory PD (CAPD) and automated PD (APD) modalities. Overall, 13.3% of patients stopped PD within 90 days. Of patients starting directly on APD, 14.3% stopped PD within 90 days. Of patients starting on CAPD, 12.6% stop...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Examination of survival after transfer from peritoneal dialysis to hemodialysis.
Authors: Piraino B, Wyman AE, Sheth H Abstract Data on survival after transfer from peritoneal dialysis (PD) to hemodialysis (HD) is conflicting. We reviewed two decades of outcomes in a PD program to examine short-term survival after transfer from PD to HD. Of 379 patients on PD, 33% transferred to HD. The reasons for transfer were PD-related infections (340%), uremia or failure to thrive (26%), PD catheter problems or loss of mechanical skills (15%), dementia or unable to train (7%), noncompliant with PD (7%), other (10%, including gastrointestinal complications, hernia, encapsulating peritoneal sclerosi...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Early start of combination therapy with hemodialysis and peritoneal dialysis prolongs survival and reduces cardiovascular events in male patients.
Authors: Suzuki H, Hoshi H, Inoue T, Kikuta T, Tsuda M, Takenaka T Abstract Although peritoneal dialysis (PD) has been recommended for initial dialysis therapy, a larger proportion of patients with end-stage renal disease choose hemodialysis (HD) instead. Several previous studies comparing the outcomes of these two therapies, including survival rates and cardiovascular events, have not clearly demonstrated the superiority of one over the other. Our recent study indicated that, compared with HD or PD alone, renal replacement therapy with HD and PD in combination prolongs survival and reduces cardiovascular ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Continuous ambulatory Peritoneal dialysis beyond a decade: cases from a single center.
Authors: Nobe K, Inoue T, Nodaira Y, Kimura Y, Okayama M, Gen S, Seto T, Sueyoshi K, Takane H, Takenaka T, Okada H, Suzuki H Abstract A broad consensus has not been reached on the appropriate timing for cessation of peritoneal dialysis (PD). Decreasing urine volume, repeated and refractory peritonitis, and deterioration of the peritoneal membrane are major reasons to stop PD. Also, the link between length of time on PD and encapsulating peritoneal sclerosis (EPS) should be an additional concern. The aim of the present study was to investigate patients who had been on continuous ambulatory PD (CAPD) for a l...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research