Does bioimpedance analysis or measurement of natriuretic peptides aid volume assessment in peritoneal dialysis patients?
Authors: Davenport A Abstract Cardiovascular mortality remains the commonest cause of death for peritoneal dialysis patients. As such, preventing persistent hypervolemia is important. On the other hand, hypovolemia may potentially risk episodes of acute kidney injury and loss of residual renal function, a major determinant of peritoneal dialysis technique survival. Bioimpedance has developed from a single-frequency research tool to a multi-frequency bioelectrical impedance analysis readily available in the clinic and capable of measuring extracellular, intracellular, and total body water. Similarly, natriu...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Hemoperitoneum in a peritoneal dialysis patient from a retroperitoneal source.
Authors: Balsera C, Guest S Abstract Hemoperitoneum in peritoneal dialysis patients is a known but infrequent complication. Hemoperitoneum is more frequent in women because of its association with a variety of gynecologic presentations such as reflux menstruation, ovulation, endometrial tissue implants within the peritoneal cavity (endometriosis), and bleeding follicular cysts. Other intraperitoneal causes of hemoperitoneum include minor catheter or abdominal trauma, vascular anomalies, or hepatic or splenic cysts. Less frequently encountered is a presentation of hemoperitoneum from a retroperitoneal sourc...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Nondialytic therapy for end-stage renal disease is an underutilized care paradigm in the United States: time for a more robust reappraisal of this treatment option.
Authors: Onuigbo MA Abstract Nondialytic therapy (NDT)--also calledconservative kidney management--is a growing modality of treatment for select chronic kidney disease and end-stage renal disease (ESRD) patients globally. Nevertheless, NDT is rarely practiced in the United States. We set out to investigate NDT activity before initiation of renal replacement therapy in a Northwestern Wisconsin Mayo Clinic ESRD population. Records of all prevalent ESRD patients on chronic hemodialysis in our practice were retrospectively reviewed in May 2012. Dialysis nurses and social workers were informally interviewed to ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Effects of spironolactone on residual renal function and peritoneal function in peritoneal dialysis patients.
Authors: Yelken B, Gorgulu N, Gursu M, Yazici H, Caliskan Y, Telci A, Ozturk S, Kazancioglu R, Ecder T, Bozfakioglu S Abstract There is increasing evidence that long-term peritoneal dialysis (PD) is associated with structural changes in the peritoneal membrane. Inhibition of the renin-angiotensin system has been demonstrated to lessen peritoneal injury and to slow the decline in residual renal function. Whether spironolactone affects residual renal function in addition to the peritoneal membrane is unknown. We evaluated 23 patients (13 women) with a glomerular filtration rate of 2 mL/min/1.73 m2 or more wh...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Subcutaneous pathway diversion for peritoneal dialysis catheter salvage.
Authors: Sakurada T, Okamoto T, Oishi D, Koitabashi K, Sueki S, Kaneshiro N, Matsui K, Nakazawa R, Yoshioka M, Konno Y, Sato Y, Shibagaki Y, Chikaraishi T, Kimura K Abstract Peritoneal dialysis (PD) catheter-related infection is still is the most troublesome problem for continuation of PD without the need to switch to hemodialysis. We have been performing subcutaneous pathway diversion (SPD) as a surgical treatment for refractory exit-site and tunnel infection (ESTI). To clarify the efficacy and safety of SPD, we conducted a retrospective study. From August 2008 to August 2013, 30 SPDs were performed in 26...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Peritoneal solute transport rate as an independent risk factor for total and cardiovascular mortality in a population of peritoneal dialysis patients.
Authors: Janda K, Krzanowski M, Dumnicka P, Kuśnierz-Cabala B, Miarka P, Sułowicz W Abstract The aim of the present study was to assess the influence of peritoneal permeability expressed as the dialysate-to-plasma ratio of creatinine (D/P Cr) on total and cardiovascular (CV) mortality in a population of peritoneal dialysis (PD) patients during a 6-year observation period. The study recruited 55 patients (mean age: 53 years) treated with PD for a median of 24 months. Hematology parameters and serum albumin were determined using routine methods. Tumor necrosis factor alpha (TNF-alpha) and transforming grow...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

The value of osmotic conductance and free water transport in the prediction of encapsulating peritoneal sclerosis.
Authors: Sampimon DE, Barreto DL, Coester AM, Struijk DG, Krediet RT Abstract Qualitative assessments in long-term patients and in those with encapsulating peritoneal sclerosis (EPS) have shown that impaired osmotic conductance is likely a factor contributing to the presence of ultrafiltration failure in those individuals. In the present study, we investigated the value of osmotic conductance, its components LpA and the reflection coefficient sigma, and free water transport (FWT) in 12 patients with EPS, in 21 patients with long-term ultrafiltration failure, and in 26 time-restricted control subjects with ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Evaluation of a single-item screening question to detect limited health literacy in peritoneal dialysis patients.
Authors: Jain D, Sheth H, Bender FH, Weisbord SD, Green JA Abstract Studies have shown that a single-item question might be useful in identifying patients with limited health literacy. However, the utility of the approach has not been studied in patients receiving maintenance peritoneal dialysis (PD). We assessed health literacy in a cohort of 31 PD patients by administering the Rapid Estimate of Adult Literacy in Medicine (REALM) and a single-item health literacy (SHL) screening question "How confident are you filling out medical forms by yourself?" (Extremely, Quite a bit, Somewhat, A little bit, or Not ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Long-term survival benefits of combined hemodialysis and peritoneal dialysis.
Authors: Suzuki H, Hoshi H, Inoue T, Kikuta T, Takane H, Takenaka T, Watanabe Y, Okada H, Kimura Y Abstract Recently, it was reported that concomitant hemodialysis (HD) in peritoneal dialysis (PD) patients facilitated continuation of PD treatment and mitigated the deterioration of peritoneal function in patients with uremic symptoms and excess body fluid associated with loss of residual renal function. To determine the effect of combined HD and PD on patient and technique survival, we undertook a retrospective cohort study of patients who underwent PD at Saitama Medical University Hospital between 1995 and...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Early technique success after initiation of treatment with urgent-start peritoneal dialysis.
In this report, we describe 90-day technique success and causes of hospitalization in 81 patients initiating PD in our urgent-start pathway. PMID: 25338420 [PubMed - indexed for MEDLINE] (Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis)
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Cardiovascular disease in chronic kidney disease: risk factors, pathogenesis, and prevention.
Authors: Ardhanari S, Alpert MA, Aggarwal K Abstract Patients with chronic kidney disease (CKD) experience serious adverse cardiovascular (CV) consequences. Cardiovascular disease is the leading cause of morbidity and mortality in patients with CKD, being secondary not only to an increased prevalence of traditional CV risk factors, but also to the presence of a wide array of nontraditional risk factors unique to patients with CKD. Pathogenesis includes both functional and structural alterations in the CV system. Those alterations give rise to a wide range of clinical CV syndromes, including ischemic heart ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Diurnal variations of blood glucose by continuous blood glucose monitoring in peritoneal dialysis patients with diabetes.
Authors: Mori T, Chida M, Oba I, Koizumi K, Furusho M, Tanno M, Naganuma E, Ito S Abstract Exaggerated postprandial increase in blood glucose has been postulated to be associated with cardiovascular injury. The concentration of blood glucose is altered by glucose absorption from peritoneal dialysis (PD) fluids. In PD patients, we used continuous blood glucose monitoring (CGM) to analyze diurnal variations in blood glucose. Diurnal blood glucose was determined in 10 diabetic PD patients who used CGM (iPro2: Medtronic, Northridge, CA, U.S.A.) for 3 days. Blood glucose concentrations before and after glycemic...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Peritoneal dialysis peritonitis: common presentation by an uncommon organism.
We present a case of peritonitis in a patient on automated PD in whom the infection was not related to a break in PD technique, but to an unusual cause: retrograde transmission of a gonococcal organism. PMID: 25338423 [PubMed - indexed for MEDLINE] (Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis)
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Hyperosmolality-mediated peritoneal microvascular vasodilation is linked to aquaporin function.
Authors: Zakaria el R, Althani A, Fawzi AA, Fituri OM Abstract Glucose-based peritoneal dialysis (PD) solutions dilate the parietal and visceral peritoneal microvasculature by endothelium-dependent mechanisms that primarily involve hyperosmolality. This PD-mediated dilation occurs by active intracellular glucose uptake and adenosine Al receptor activation, and by hyperosmolality-stimulated glibenclamide-sensitive potassium channels. Both pathways invoke NO as a second messenger for vasodilation. We hypothesized that during crystalloid-induced osmosis, the osmotic water flux through the transendothelial wat...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Blood glucose levels in peritoneal dialysis are better reflected by HbA1c than by glycated albumin.
Authors: Watanabe Y, Ohno Y, Inoue T, Takane H, Okada H, Suzuki H Abstract A recent study indicated that, compared with glycated hemoglobin (HbA1c), glycated albumin (GA) provides a more accurate assessment of glycemic control in diabetic patients on hemodialysis. However, the suitability of GA for this purpose in peritoneal dialysis (PD) patients is questionable. We measured blood glucose, GA, HbA1c, serum albumin, protein losses in urine and dialysate, protein catabolic rate, hemoglobin, and dose of erythropoiesis-stimulating agents in 71 PD patients [20 with diabetes (DM), 51 without DM]. In both DM and...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research