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Relationship Between Peritoneal Transport Characteristics and Natriuretic Peptides in Peritoneal Dialysis Patients.
Authors: Kojima S, Sakurada T, Uehara M, Okamoto T, Kaneshiro N, Konno Y, Shibagaki Y Abstract Few studies have attempted to evaluate the relationship between peritoneal permeability and fluid status in peritoneal dialysis (PD). The aim of the present study was to clarify the relationship between change in the dialysate-to-plasma ratio of creatinine (D/P Cr) and change in fluid status as evaluated by natriuretic peptides. We studied 49 PD patients (29 men, 62 ± 11 years, 36.7% with diabetes) who underwent a peritoneal equilibration test at least twice after PD initiation. We evaluated correlations between...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Glucose and Insulin Response to Peritoneal Dialysis Fluid in Diabetic and Nondiabetic Peritoneal Dialysis Patients.
Authors: Oba I, Mori T, Chida M, Kurasawa N, Naganuma E, Sato E, Koizumi K, Sato S, Tsuchikawa M, Ito S Abstract A postprandial increase in blood glucose in peritoneal dialysis (PD) patients with diabetes was observed in our previous study using continuous blood glucose monitoring. The response was observed in diabetic but not in nondiabetic PD patients. In addition, the response was reduced when patients used icodextrin; glucose absorbed from the peritoneum was responsible for the postprandial increase in blood glucose. Because our PD patients often change their PD fluid before meals, the present study ai...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Using a Peritoneal Dialysis Access Simulator in Surgical Training for Nephrologists.
Authors: Sakurada T, Taki Y, Kojima S, Oishi D, Koitabashi K, Sueki S, Kaneshiro N, Shibagaki Y Abstract In Japan, peritoneal dialysis (PD) catheter insertion has been performed by both nephrologists and surgeons. However, nephrologists have fewer opportunities to train in the insertion procedure. We therefore used a PD access simulator to provide training in this operative technique for nephrologists. A PD access simulator developed by Terumo Medical Corporation was used for the training. The simulator uses a mannequin made of acrylic resin. The abdominal wall of a pig is attached to the abdominal area, a...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Lymphangiogenesis and Lymphatic Absorption Are Related and Increased in Chronic Kidney Failure, Independent of Exposure to Dialysis Solutions.
Authors: Vlahu CA, de Graaff M, Aten J, Struijk DG, Krediet RT Abstract Increased lymphatic absorption might contribute to ultrafiltration failure in peritoneal dialysis (PD). Lymphangiogenesis develops during PD, but little is known about the relationship between its morphologic and functional parameters. The relationships between lymph vessel density, the effective lymphatic absorption rate (ELAR), and fibrosis were investigated in a rat model of chronic kidney failure (CKD) with exposure to dialysis solutions. Wistar rats (n = 44) were allocated to these groups: NKF (normal kidney function), CKD (70% ne...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

European Training and Research in Peritoneal Dialysis--A Network to Deliver Scientific Peritoneal Dialysis Training to a New Generation of Researchers.
Authors: Machowska A, van Wier T, Aufricht C, Beelen R, Rutherford P Abstract Peritoneal dialysis (PD) utilization varies across countries, and of the factors that explain the variation, the scientific and clinical knowledge of health care professionals is potentially important. In this paper, we describe a European collaboration--between 8 academic PD research programs, a small-to-medium-sized enterprise, and a large PD product manufacturer--that received significant research funding from the EU commission to establish a training network. European Training and Research in Peritoneal Dialysis (EuTRiPD) is ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

The Vasopressin 2 Receptor Antagonist Tolvaptan Improves Nutrition and Inflammatory States in Peritoneal Dialysis Patients with Diabetes Mellitus.
Authors: Hiramatsu T, Asai K, Ozeki A, Saka M, Hobo A, Furuta S Abstract Previously, we reported that, in peritoneal dialysis (PD) patients, tolvaptan preserves residual renal function and ameliorates left ventricular hypertrophy. Here, we evaluated the effect of tolvaptan in terms of nutrition and inflammatory states. Of 24 incident PD patients with diabetes, 12 were assigned to a control group that did not receive tolvaptan, and 12, to a group that, 2 weeks after initiation of PD, received tolvaptan 15 mg daily for 12 months. At baseline and at 6 and 12 months after initiation of PD, we evaluated serum C...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

A Comparison Study of Glucose Fluctuation During Automated Peritoneal Dialysis and Continuous Ambulatory Peritoneal Dialysis.
Authors: Okada E, Oishi D, Sakurada T, Yasuda T, Shibagaki Y Abstract In recent years, it has become possible to examine an individual's daily glucose profile with a continuous glucose monitoring system (CGMS). The aim of the present study was to use a CGMS to evaluate the difference in glucose fluctuation between diabetic patients on automated peritoneal dialysis (APD) and those on continuous ambulatory peritoneal dialysis (CAPD). We retrospectively studied 20 diabetic patients on peritoneal dialysis (16 men, 4 women; mean age: 55 ± 10 years) who used a CGMS a total of 23 times (12 times by APD users, 11...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Association Between Home Blood Pressure and Body Composition by Bioimpedance Monitoring in Patients Undergoing Peritoneal Dialysis.
Authors: Kurasawa N, Mori T, Naganuma E, Sato E, Koizumi K, Sato S, Oba I, Tsuchikawa M, Ito S Abstract Home blood pressure (HBP) is an independent predictor of cardiovascular and renal function. However, no particular guidelines have been established for optimal HBP in peritoneal dialysis (PD) patients. Bioelectrical impedance analysis (BIA) is a beneficial tool for determining body composition. In the present study, we used BIA to determine body composition parameters that might play a role in the regulation of HBP in PD patients, and we compared HBP with office blood pressure (BP). Our study enrolled 15...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Relationship of Normalized Protein Catabolic Rate with Nutrition Status and Long-Term Survival in Peritoneal Dialysis Patients.
In conclusion, lower nPCR is associated with poorer nutrition status and increased risk of all-cause mortality in PD patients followed for up to 11 years. PMID: 26714388 [PubMed - in process] (Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis)
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Association Between Residual Kidney Function and Visit-to-Visit Blood Pressure Variability in Peritoneal Dialysis Patients.
Authors: Yokota K, Sakurada T, Koitabashi K, Shibagaki Y, Kario K, Kimura K Abstract Visit-to-visit blood pressure (BP) variability has recently been recognized as an important risk factor for decline of residual kidney function (RKF) in patients with chronic kidney disease. However little is known about the impact of visit-to-visit BP variability on RKF in peritoneal dialysis (PD) patients. We retrospectively studied the association between RKF and visit-to-visit BP variability in 42 patients who started on PD between February 2006 and March 2012. Residual kidney function was defined as the mean of the ur...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Hypotension in Infants on Chronic Peritoneal Dialysis: Mechanisms, Complications, and Management.
Authors: Vidal E, Schaefer F Abstract Hypotension represents a very serious clinical problem in patients receiving renal replacement therapy, and it is associated with a significant increase in mortality risk. Infants on chronic peritoneal dialysis (CPD) can be particularly prone to chronic hypotension because of the hyponatremic hypovolemia risk related to their primary renal disease, their nutritional needs, and their peritoneal membrane characteristics. In this setting, if an acute clinical event leads to a further decline in systolic blood pressure, the counteract and perfusion pressure autoregulatory ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Impact of Peritoneal Dialysis Catheter Insertion by a Nephrologist: Results of a Questionnaire Survey of Patients and Nurses.
Authors: Washida N, Aikawa K, Inoue S, Kasai T, Shinozuka K, Morimoto K, Hosoya K, Hayashi K, Itoh H Abstract Peritoneal dialysis (PD) is an excellent dialysis mo- dality, but it is underutilized in the United States and Japan. In the present study, we evaluated the impact of interventional nephrology in PD on the impres- sions held by patients and nurses about selection of a renal replacement therapy and the complications associated with PD therapy. Over aperiod of 7 years, PD catheter insertion in 120 patients with end-stage renal disease (age: 63.0 ± 13.3 years) was performed by nephrologists at Keio U...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Offering Patients Therapy Options in Unplanned Start: Development and Implementation of an Education Program for Unplanned-Start Patients.
Authors: Machowska A, Alscher MD, Vanga SR, Koch M, Aarup M, Rutherford P Abstract Unplanned start of dialysis is still a common and important problem for dialysis units in Europe and across the world: 30%-50% of patients can commence therapy in that way. Such patients are known to experience increased morbidity and mortality, to make greater demands on health care resources, and to be less likely to receive their dialysis modality choice. We therefore aimed to meet the specific needs of unplanned-start patients by developing and implementing an Unplanned Start Educational Programme in dialysis units. The ...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Mortality Comparison of Hemodialysis and Peritoneal Dialysis Patients at a Single Japanese Center.
Authors: Koga S, Ito H Abstract To investigate whether peritoneal dialysis (PD) is useful as a first modality in Japan, where hemodialysis (HD) is used in 97% of all patients on maintenance dialysis, we used intention-to-treat (ITT) and as-treated analyses to examine patient survival at our center, where HD and PD are used almost equally. In the ITT analysis, survival was significantly better in the PD group than in the HD group (p = 0.009). Meanwhile, the as-treated analysis did not reveal any significant differences in survival between the HD and PD groups. Survival for patients who underwent combined th...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - January 16, 2016 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research

Predictors of bone mineral density in dialyzed and non-dialyzed patients with chronic kidney disease.
In this study, we assessed predictors of bone mineral density (BMD) in chronic kidney disease (CKD) patients with declining renal function. Among the 106 patients enrolled, 26 were treated with peritoneal dialysis [PD: 15 women; age; 55.7 +/- 17.7 years; dialysis vintage: 16.6 months (range: 6.3 - 45.5 months)]; 60, with hemodialysis [HD: 26 women; age: 54.8 +/- 15.3 years; dialysis vintage: 36.9 months (range: 6.0 - 279.6 months)]; and 20 were in CKD stage 2 or 3 (11 women; age: 49.4 +/- 15.8 years). We measured BMD in the femoral neck. Anthropometric measurements assessing nutrition status and routine laboratory paramete...
Source: Advances in Peritoneal Dialysis. Conference on Peritoneal Dialysis - November 19, 2015 Category: Urology & Nephrology Tags: Adv Perit Dial Source Type: research