Catastrophic Endgames: Emerging Mechanisms of Telomere-Driven Genomic Instability
Publication date: Available online 13 March 2020Source: Trends in GeneticsAuthor(s): Kez Cleal, Duncan M. Baird (Source: Trends in Genetics)
Source: Trends in Genetics - March 13, 2020 Category: Genetics & Stem Cells Source Type: research
Editorial Board and Contents
Publication date: April 2020Source: Trends in Genetics, Volume 36, Issue 4Author(s): (Source: Trends in Genetics)
Source: Trends in Genetics - March 10, 2020 Category: Genetics & Stem Cells Source Type: research
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Publication date: April 2020Source: Trends in Genetics, Volume 36, Issue 4Author(s): (Source: Trends in Genetics)
Source: Trends in Genetics - March 10, 2020 Category: Genetics & Stem Cells Source Type: research
Nothobranchius furzeri (African Turquoise Killifish)
Publication date: Available online 28 February 2020Source: Trends in GeneticsAuthor(s): Rongfeng Cui, David Willemsen, Dario Riccardo Valenzano (Source: Trends in Genetics)
Source: Trends in Genetics - March 1, 2020 Category: Genetics & Stem Cells Source Type: research
A Multi-Omics Perspective of Quantitative Trait Loci in Precision Medicine
Publication date: Available online 24 February 2020Source: Trends in GeneticsAuthor(s): Youqiong Ye, Zhao Zhang, Yaoming Liu, Lixia Diao, Leng Han (Source: Trends in Genetics)
Source: Trends in Genetics - February 26, 2020 Category: Genetics & Stem Cells Source Type: research
On the Molecular Mechanisms Regulating Animal Cell Size Homeostasis
Publication date: Available online 20 February 2020Source: Trends in GeneticsAuthor(s): Evgeny Zatulovskiy, Jan M. SkotheimCell size is fundamental to cell physiology because it sets the scale of intracellular geometry, organelles, and biosynthetic processes. In animal cells, size homeostasis is controlled through two phenomenologically distinct mechanisms. First, size-dependent cell cycle progression ensures that smaller cells delay cell cycle progression to accumulate more biomass than larger cells prior to cell division. Second, size-dependent cell growth ensures that larger and smaller cells grow slower per unit mass t...
Source: Trends in Genetics - February 21, 2020 Category: Genetics & Stem Cells Source Type: research
Citrullus lanatus
Publication date: Available online 17 February 2020Source: Trends in GeneticsAuthor(s): Shaogui Guo, Honghe Sun, Yong Xu, Zhangjun Fei (Source: Trends in Genetics)
Source: Trends in Genetics - February 18, 2020 Category: Genetics & Stem Cells Source Type: research
The Telomere Paradox: Stable Genome Preservation with Rapidly Evolving Proteins
Publication date: Available online 12 February 2020Source: Trends in GeneticsAuthor(s): Bastien Saint-Leandre, Mia T. LevineTelomeres ensure chromosome length homeostasis and protection from catastrophic end-to-end chromosome fusions. All eukaryotes require this essential, strictly conserved telomere-dependent genome preservation. However, recent evolutionary analyses of mammals, plants, and flies report pervasive rapid evolution of telomere proteins. The causes of this paradoxical observation – that unconserved machinery underlies an essential, conserved function – remain enigmatic. Indeed, these fast-evolving telomer...
Source: Trends in Genetics - February 14, 2020 Category: Genetics & Stem Cells Source Type: research
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Publication date: March 2020Source: Trends in Genetics, Volume 36, Issue 3Author(s): (Source: Trends in Genetics)
Source: Trends in Genetics - February 12, 2020 Category: Genetics & Stem Cells Source Type: research
Editorial Board and Contents
Publication date: March 2020Source: Trends in Genetics, Volume 36, Issue 3Author(s): (Source: Trends in Genetics)
Source: Trends in Genetics - February 12, 2020 Category: Genetics & Stem Cells Source Type: research
Advances in the Evolutionary Understanding of MHC Polymorphism
Publication date: Available online 7 February 2020Source: Trends in GeneticsAuthor(s): Jacek Radwan, Wiesław Babik, Jim Kaufman, Tobias L. Lenz, Jamie WinternitzProteins encoded by the classical major histocompatibility complex (MHC) genes incite the vertebrate adaptive immune response by presenting peptide antigens on the cell surface. Here, we review mechanisms explaining landmark features of these genes: extreme polymorphism, excess of nonsynonymous changes in peptide-binding domains, and long gene genealogies. Recent studies provide evidence that these features may arise due to pathogens evolving ways to evade immune ...
Source: Trends in Genetics - February 8, 2020 Category: Genetics & Stem Cells Source Type: research
Genetic Variation across Phenotypic Severity of Autism
Publication date: Available online 6 February 2020Source: Trends in GeneticsAuthor(s): Claudio TomaIt is still unclear how genetic factors of autism spectrum disorder (ASD) are implicated in the significant clinical heterogeneity ranging from intellectual disability (ID) to high-functioning profiles. Here, evidence from recent genetic studies encompassing common and rare variants are combined to suggest a genetic model that may explain the broad gradient of phenotypic severity observed in ASD. (Source: Trends in Genetics)
Source: Trends in Genetics - February 8, 2020 Category: Genetics & Stem Cells Source Type: research
Mouse Systems Genetics as a Prelude to Precision Medicine
Publication date: Available online 6 February 2020Source: Trends in GeneticsAuthor(s): Hao Li, Johan AuwerxMouse models have been instrumental in understanding human disease biology and proposing possible new treatments. The precise control of the environment and genetic composition of mice allows more rigorous observations, but limits the generalizability and translatability of the results into human applications. In the era of precision medicine, strategies using mouse models have to be revisited to effectively emulate human populations. Systems genetics is one promising paradigm that may promote the transition to novel ...
Source: Trends in Genetics - February 8, 2020 Category: Genetics & Stem Cells Source Type: research
What Is a Transcriptional Burst?
Publication date: Available online 5 February 2020Source: Trends in GeneticsAuthor(s): Edward Tunnacliffe, Jonathan R. ChubbThe idea that gene activity can be discontinuous will not surprise many biologists – many genes are restricted in when and where they can be expressed. Yet during the past 15 years, a collection of observations compiled under the umbrella term ‘transcriptional bursting’ has received considerable interest. Direct visualization of the dynamics of discontinuous transcription has expanded our understanding of basic transcriptional mechanisms and their regulation and provides a real-time readout of g...
Source: Trends in Genetics - February 6, 2020 Category: Genetics & Stem Cells Source Type: research
Marmota marmota
Publication date: Available online 3 February 2020Source: Trends in GeneticsAuthor(s): Toni I. Gossmann, Markus Ralser (Source: Trends in Genetics)
Source: Trends in Genetics - February 5, 2020 Category: Genetics & Stem Cells Source Type: research
