Compensatory Evolution of Gene Expression
Publication date: Available online 20 October 2019Source: Trends in GeneticsAuthor(s): Sarah A. Signor, Sergey V. Nuzhdin (Source: Trends in Genetics)
Source: Trends in Genetics - October 21, 2019 Category: Genetics & Stem Cells Source Type: research
Saccharomyces cerevisiae
Publication date: Available online 17 October 2019Source: Trends in GeneticsAuthor(s): Ignacio Belda, Javier Ruiz, Antonio Santos, Nïel Van Wyk, Isak S. Pretorius (Source: Trends in Genetics)
Source: Trends in Genetics - October 18, 2019 Category: Genetics & Stem Cells Source Type: research
Many Ways to Build a Polyp
Publication date: Available online 16 October 2019Source: Trends in GeneticsAuthor(s): Detlev ArendtThe freshwater cnidarian Hydra has been studied for centuries for its unique regenerative capacities. Whole-body single-cell transcriptomics now reveal cellular lineages and gene regulatory networks that build the Hydra polyp. For the first time, transcription factor signatures allow direct comparison of the polyp body plan between Hydra and sea anemone. (Source: Trends in Genetics)
Source: Trends in Genetics - October 17, 2019 Category: Genetics & Stem Cells Source Type: research
Toward Clinical Implementation of Next-Generation Sequencing-Based Genetic Testing in Rare Diseases: Where Are We?
Publication date: Available online 14 October 2019Source: Trends in GeneticsAuthor(s): Zhichao Liu, Liyuan Zhu, Ruth Roberts, Weida TongNext-generation sequencing (NGS) technologies have changed the landscape of genetic testing in rare diseases. However, the rapid evolution of NGS technologies has outpaced its clinical adoption. Here, we re-evaluate the critical steps in the clinical application of NGS-based genetic testing from an informatics perspective. We suggest a ‘fit-for-purpose’ triage of current NGS technologies. We also point out potential shortcomings in the clinical management of genetic variants and offer ...
Source: Trends in Genetics - October 15, 2019 Category: Genetics & Stem Cells Source Type: research
Landscape of Noncoding RNA in Prostate Cancer
Publication date: Available online 14 October 2019Source: Trends in GeneticsAuthor(s): Junjie T. Hua, Sujun Chen, Housheng H. HeThe transcriptome of prostate cancer is highly heterogeneous, with noncoding transcripts being essential players. Long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are two unique classes of noncoding RNA drawing increasing attention. Biologically, they have intriguing properties with important regulatory functions. Clinically, they present as promising biomarkers and therapeutic targets. Recent advancements in technologies have opened up new directions for noncoding RNA research, which in...
Source: Trends in Genetics - October 15, 2019 Category: Genetics & Stem Cells Source Type: research
