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Efficacy and safety profile of autologous blood versus tetracycline pleurodesis for malignant pleural effusion
Conclusions: ABP was as effective as tetracycline in the treatment of MPE. ABP produced less pain and fever, and could shorten the hospital stay. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - March 27, 2015 Category: Respiratory Medicine Authors: Keeratichananont, W., Limthon, T., Keeratichananont, S. Tags: Original Research Source Type: research

Pulmonary artery diastolic pressure gradient as an indicator of severity of illness in patients with pulmonary hypertension related to left-sided heart disease
Discussion: Among patients with Group 2 PH, elevated DPG proved to be a more specific indicator of worse functional status than the historically used TPG. International guidelines and protocols for performing RHC for the assessment and diagnosis of PH should include the measurement of DPG. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - March 27, 2015 Category: Respiratory Medicine Authors: Howard, C., Rangajhavala, K., Safdar, Z. Tags: Original Research Source Type: research

Nocardia cyriacigeorgica in an immunocompetent patient
(Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - January 29, 2015 Category: Respiratory Medicine Authors: Kibe, S., Meigh, R., Moon, T., Kastelik, J., Morjaria, J. Tags: Letter to the Editor Source Type: research

Indwelling pleural catheters for pleural effusions associated with end-stage renal disease: a case series
Conclusion: IPC insertion for pleural effusions associated with end-stage renal disease appears safe and effective. Larger studies are needed, particularly regarding the impact of this intervention on quality of life. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - January 29, 2015 Category: Respiratory Medicine Authors: Potechin, R., Amjadi, K., Srour, N. Tags: Reviews Source Type: research

Evidence for the efficacy of aztreonam for inhalation solution in the management of Pseudomonas aeruginosa in patients with cystic fibrosis
Chronic airway infection in cystic fibrosis (CF) is a main cause of the increased morbidity and mortality found with this disease. The most common cause of Gram-negative infection is Pseudomonas aeruginosa. The introduction of inhaled antibiotics has changed the lives of affected patients and the clinical outcome of this infection; this article focuses on the use of inhaled antibiotics in chronic P. aeruginosa infection in CF, and specifically on studies including the use of inhaled aztreonam lysine in P. aeruginosa infection. Studies were identified using PubMed and ClinicalTrials.gov, searching for ‘inhaled aztreon...
Source: Therapeutic Advances in Respiratory Disease - January 29, 2015 Category: Respiratory Medicine Authors: Hansen, C., Skov, M. Tags: Reviews Source Type: research

Comparative efficacy of long-acting muscarinic antagonists in preventing COPD exacerbations: a network meta-analysis and meta-regression
Conclusion: All LAMAs were equally effective in preventing moderate-to-severe exacerbations. Aclidinium was associated with the lowest risk for severe exacerbations when treatment duration was 6 months or longer. The concomitant use of LABA may not enhance the efficacy of LAMAs in preventing COPD exacerbations. More studies are needed to further examine above findings. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - January 29, 2015 Category: Respiratory Medicine Authors: Oba, Y., Lone, N. A. Tags: Original Research Source Type: research

Oxygen therapy: time to move on?
This analysis examines the roots of clinical practice regarding oxygen therapy and finds that some aspects have changed very little over the past 200 years. Oxygen is commonly prescribed and administered as a therapy across all healthcare settings, particularly for the treatment and management of respiratory conditions, both acute and chronic. Yet despite its widespread use and recent advances in understanding and guidance, poor practice and controversies regarding its use persist. This historical analysis highlights origins in practice that may suggest where the roots of these fallacies lie, highlighting potential ambigui...
Source: Therapeutic Advances in Respiratory Disease - December 1, 2014 Category: Respiratory Medicine Authors: Kelly, C. Tags: Reviews Source Type: research

An update on the efficacy of oral corticosteroids in the treatment of wheezing episodes in preschool children
Traditionally, oral corticosteroids (OCSs) have been the mainstay of treatment for acute wheezing episodes among preschool children with a history of recurrent wheezing. Although there is substantial evidence for the efficacy of OCSs as a treatment for asthma exacerbations in school-aged children and adolescents, recent clinical studies questioned the benefits of OCSs as a treatment for acute wheezing in preschool children. This review summarizes the current evidence on the efficacy of OCSs as a treatment for acute wheezing episodes among preschool age children with episodic wheezing, focusing on studies performed in three...
Source: Therapeutic Advances in Respiratory Disease - December 1, 2014 Category: Respiratory Medicine Authors: Collins, A. D., Beigelman, A. Tags: Reviews Source Type: research

Effects of a combination of umeclidinium/vilanterol on exercise endurance in patients with chronic obstructive pulmonary disease: two randomized, double-blind clinical trials
Conclusions: UMEC/VI improved lung function and EET. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - December 1, 2014 Category: Respiratory Medicine Authors: Maltais, F., Singh, S., Donald, A. C., Crater, G., Church, A., Goh, A. H., Riley, J. H. Tags: Original Research Source Type: research

Endobronchial lipoma: bronchoscopy, imaging and pathology
(Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 17, 2014 Category: Respiratory Medicine Authors: Harris, K., Dhillon, S., Huang, M., Kumar, A., Qiu, J. Tags: Letter to the Editor Source Type: research

{alpha}1 Antitrypsin deficiency: current best practice in testing and augmentation therapy
α1 Antitrypsin deficiency (AATD) increases the risk of chronic obstructive pulmonary disease (COPD), liver disease and other conditions. Although it is not a rare disease, it is a condition rarely diagnosed because of unawareness by most healthcare providers who manage subjects at risk. Testing recommendations have been published and strongly suggest testing all subjects with confirmed COPD, cryptogenic liver cirrhosis, subjects with incompletely reversible airflow obstruction and siblings of affected individuals. Testing strategies usually imply a combination of measures of α1 antitrypsin (AAT) levels, phenoty...
Source: Therapeutic Advances in Respiratory Disease - September 17, 2014 Category: Respiratory Medicine Authors: Campos, M. A., Lascano, J. Tags: Review Source Type: research

Omalizumab: a new treatment option for allergic bronchopulmonary aspergillosis in patients with cystic fibrosis
Conclusion: Omalizumab has the potential to be an additional and solitary treatment option in patients with CF and ABPA. Early onset treatment may be beneficial and patients with early stage of lung disease seem to benefit more. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - September 17, 2014 Category: Respiratory Medicine Authors: Lehmann, S., Pfannenstiel, C., Friedrichs, F., Kroger, K., Wagner, N., Tenbrock, K. Tags: Original Research Source Type: research

A renal angiomyolipoma with extension to the renal vein and asymptomatic fat pulmonary embolus
Renal angiomyolipoma (AML) is a rare benign tumor that can extend into the renal vein, inferior vena cava and the right atrium. AML is a mesenchymal tumor composed of smooth muscle, fat and vascular elements. In rare instances, the tumor may release a fatty tissue to the pulmonary vasculature, which can lead to cardiopulmonary collapse and death. Only four cases of fat pulmonary embolism secondary to AML have been reported in the literature but our case was the first to present as asymptomatic. Our patient had left renal AML extending to the renal vein that was associated with fat pulmonary embolus. The patient underwent u...
Source: Therapeutic Advances in Respiratory Disease - July 17, 2014 Category: Respiratory Medicine Authors: Harris, K., Hatem, E., Maroun, R., Seminara, D., Maniatis, T. Tags: Letter to the Editor Source Type: research

Current best practice in the management of pulmonary and systemic sarcoidosis
Sarcoidosis is a systemic inflammatory disease of unknown etiology that is characterized by the presence of granulomatous inflammation in affected tissues. It can affect essentially any organ system but shows a predilection for the lungs, eyes, and skin. Accurate epidemiological data are not available in the USA, but sarcoidosis is considered a ‘rare disease’ (prevalence less than 200,000). However, recent epidemiologic studies indicate that regional prevalence is much higher than previously estimated, especially among African American women. Additionally, mortality rates of patients with sarcoidosis are increa...
Source: Therapeutic Advances in Respiratory Disease - July 17, 2014 Category: Respiratory Medicine Authors: Amin, E. N., Closser, D. R., Crouser, E. D. Tags: Reviews Source Type: research

The safety of asthma medications during pregnancy: an update for clinicians
This article reviews the recognition and management of asthma during pregnancy, as well as general principles of asthma medication use during pregnancy. (Source: Therapeutic Advances in Respiratory Disease)
Source: Therapeutic Advances in Respiratory Disease - July 17, 2014 Category: Respiratory Medicine Authors: Namazy, J. A., Schatz, M. Tags: Reviews Source Type: research