Inflammation induces endothelial ‐to‐mesenchymal transition and promotes vascular calcification through downregulation of BMPR2
ABSTRACTEndothelial ‐to‐mesenchymal transition (EndMT) has been unveiled as a common cause for a multitude of human pathologies, including cancer and cardiovascular disease. Vascular calcification is a risk factor for ischemic vascular disorders and slowing calcification may reduce mortality in affected patients. T he absence of early biomarkers hampers the identification of patients at risk. EndMT and vascular calcification are induced upon cooperation between distinct stimuli, including inflammatory cytokines and transforming growth factor beta (TGF‐β) family members. However, how these signaling pathways interpla...
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Gonzalo S ánchez‐Duffhues,
Amaya García de Vinuesa,
Vera van de Pol,
Marlieke E. Geerts,
Margreet R. de Vries,
Stef G. T. Janson,
Hans van Dam,
Jan Lindeman,
Marie‐José Goumans,
Peter ten Dijke Tags: Original Paper Source Type: research
Intraductal patient derived xenografts of estrogen receptor α positive (ER+) breast cancer recapitulate the histopathological spectrum and metastatic potential of human lesions
This article is protected by copyright. All rights reserved. (Source: The Journal of Pathology)
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Maryse Fiche,
Valentina Scabia,
Patrick Aouad,
Laura Battista,
Assia Treboux,
Athina Stravodimou,
Khalil Zaman,
RLS,
Valerian Dormoy,
Ayyakkannu Ayyanan,
George Sflomos,
Cathrin Brisken Tags: Brief Definitive Report Source Type: research
Single ‐cell sequencing defines genetic heterogeneity in pancreatic cancer precursor lesions
The objective of this study was to characterize genetic heterogeneity in IPMNs at the single ‐cell level. We isolated single cells from fresh tissue from ten IPMNs, followed by whole genome amplification and targeted next generation sequencing of pancreatic driver genes. We then determined single‐cell genotypes using a novel multi‐sample mutation calling algorithm. Our analyses reveal ed that different mutations in the same driver gene frequently occur in the same IPMN. Two IPMNs had multiple mutations in the initiating driver geneKRAS that occurred in unique tumor clones, suggesting the possibility of polyclonal ori...
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Yuko Kuboki,
Catherine G. Fischer,
Violeta Beleva Guthrie,
Wenjie Huang,
Jun Yu,
Peter Chianchiano,
Waki Hosoda,
Hao Zhang,
Lily Zheng,
Xiaoshan Shao,
Elizabeth D. Thompson,
Kevin Waters,
Justin Poling,
Jin He,
Matthew J. Weiss,
Christopher Tags: Original Paper Source Type: research
Doxorubicin ‐induced cardiotoxicity involves IFNγ‐mediated metabolic reprogramming in cardiomyocytes
We report here that DOX‐induced heart dysfunction involves IFNγ signaling in mice. The IFNγ receptor was found to be highly expressed on cardiomyocytes, and its downstream signaling was activated in heart tissues upon DOX treatment.In vitro, IFN γ strongly aggravated the injury of cardiomyocytes exposed to DOX. Although not affecting DOX‐induced cell death, IFNγ disrupted mitochondrial respiration and fatty acid oxidation in DOX‐exposed cardiomyocytes. IFNγ extended the suppression of the AMP‐activated protein kinase (AMPK)/acetyl‐ CoA carboxylase (ACC) axis by DOX to a p38‐dependent branch. Activation of ...
Source: The Journal of Pathology - November 14, 2018 Category: Pathology Authors: Chen Ni,
Pan Ma,
Ruirui Wang,
Xiaohan Lou,
Xiaomeng Liu,
Yue Qin,
Rui Xue,
Ingolf Blasig,
Ulrike Erben,
Zhihai Qin Tags: Original Paper Source Type: research
The tyrosine phosphatase Shp ‐2 confers resistance to colonic inflammation by driving goblet cell function and crypt regeneration
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 30, 2018 Category: Pathology Authors: Jessica Gagn é‐Sansfacon,
Ariane Langlois,
Marie‐Josée Langlois,
Geneviève Coulombe,
Sarah Tremblay,
Vanessa Vaillancourt‐Lavigueur,
Cheng‐Kui Qu,
Alfredo Menendez,
Nathalie Rivard Source Type: research
Decoding transcriptomic intra –tumour heterogeneity to guide personalised medicine in ovarian cancer
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 30, 2018 Category: Pathology Authors: Tuan Zea Tan,
Valerie Heong,
Jieru Ye,
Diana Lim,
Jeffrey Low,
Mahesh Choolani,
Clare Scott,
David Shao Peng Tan,
Ruby Yun ‐Ju Huang Source Type: research
Does prenylation predict progression in NAFLD?
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 30, 2018 Category: Pathology Authors: Peyman Ghorbani,
Tyler K.T. Smith,
Morgan D. Fullerton Source Type: research
Tumor and endothelial cells collaborate via transcellular receptor complexes
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 25, 2018 Category: Pathology Authors: Sarvenaz Sarabipour,
Feilim Mac Gabhann Source Type: research
Bone marrow fibroblasts overexpress miR ‐27b and miR‐214 in step with multiple myeloma progression, dependent on tumour cell‐derived exosomes
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 25, 2018 Category: Pathology Authors: Maria Antonia Frassanito,
Vanessa Desantis,
Lucia Di Marzo,
Ilaria Craparotta,
Luca Beltrame,
Sergio Marchini,
Tiziana Annese,
Fabrizio Visino,
Marcella Arciuli,
Ilaria Saltarella,
Aurelia Lamanuzzi,
Antonio Giovanni Solimando,
Beatrice Nico, Source Type: research
ARL4C stabilized by AKT/mTOR pathway promotes the invasion of PTEN ‐deficient primary human glioblastoma
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 25, 2018 Category: Pathology Authors: Qian Chen,
Hai ‐Yan Weng,
Xiao‐Peng Tang,
Yong Lin,
Ye Yuan,
Qian Li,
Zhuo Tang,
Hai‐Bo Wu,
Shuai Yang,
Yong Li,
Xi‐Long Zhao,
Wen‐Juan Fu,
Qin Niu,
Hua Feng,
Xia Zhang,
Yan Wang,
Xiu‐Wu Bian,
Xiao‐Hong Yao Source Type: research
LGR5 promotes tumorigenicity and invasion of glioblastoma stem ‐like cells and is a potential therapeutic target for a subset of glioblastoma patients
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 25, 2018 Category: Pathology Authors: Yuan Xie,
Anders Sundstr öm,
Naga Prathyusha Maturi,
E‐Jean Tan,
Voichita Dana Marinescu,
Malin Jarvius,
Malin Tirfing,
Chuan Jin,
Lei Chen,
Magnus Essand,
Fredrik J. Swartling,
Sven Nelander,
Yiwen Jiang,
Lene Uhrbom Source Type: research
Discordant roles for FGF ligands in lung branching morphogenesis between human and mouse
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 25, 2018 Category: Pathology Authors: Soula Danopoulos,
Matthew E. Thornton,
Brendan H. Grubbs,
Mark R. Frey,
David Warburton,
Saverio Bellusci,
Denise Al Alam Source Type: research
Phenotypic and molecular dissection of Metaplastic Breast Cancer and the prognostic implications
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 23, 2018 Category: Pathology Authors: Amy Ellen McCart Reed,
Emarene Kalaw,
Katia Nones,
Mark Bettington,
Malcolm Lim,
James Bennett,
Kate Johnstone,
Jamie Rose Kutasovic,
Jodi Marie Saunus,
Stephen Kazakoff,
Qinying Xu,
Scott Wood,
Oliver Holmes,
Conrad Leonard,
Lynne Estelle R Source Type: research
Exploring the spatiotemporal genetic heterogeneity in metastatic lung adenocarcinoma using a nuclei flow ‐sorting approach
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 23, 2018 Category: Pathology Authors: Thomas Lorber,
Noemi Andor,
Tanja Dietsche,
Valeria Perrina,
Darius Juskevicius,
Karen Pereira,
Stephanie U. Greer,
Arthur Krause,
David Mueller,
Spasenija Savic Prince,
Didier Lardinois,
Michael T. Barrett,
Christian Ruiz,
Lukas Bubendorf Source Type: research
NFIB promotes cell survival by directly suppressing p21 transcription in p53 ‐mutated triple‐negative breast cancer
The Journal of Pathology,Volume 0, Issue ja, -Not available-. (Source: The Journal of Pathology)
Source: The Journal of Pathology - October 23, 2018 Category: Pathology Authors: Rong ‐Zong Liu,
The M. Vo,
Saket Jain,
Won‐Shik Choi,
Elizabeth Garcia,
Elizabeth A. Monckton,
John R. Mackey,
Roseline Godbout Source Type: research
