Novel insights into the disease dynamics of B ‐cell lymphomas in the Genomics Era
Abstract
High‐throughput sequencing has significantly contributed to revealing the molecular underpinnings of B‐cell lymphomagenesis and disease progression. It is now a widely accepted concept that the diversity of clinical responses to front‐line therapy and the development of relapsed/refractory disease are in part explained by “interpatient” genetic heterogeneity measurable by individual sets of somatic gene alterations in tumor genomes. Moreover, extensive “intratumor” heterogeneity on the genotypic and phenotypic levels is the product of ongoing tumor evolution and adaptation to various selective pressu...
Source: The Journal of Pathology - January 23, 2018 Category: Pathology Authors: Fong Chun Chan, Emilia Lim, Robert Kridel, Christian Steidl Tags: Invited Review Source Type: research
Mixed ductal ‐lobular carcinomas: evidence for progression from ductal to lobular morphology
Abstract
Mixed ductal‐lobular carcinomas (MDL) display both ductal and lobular morphology, and are an archetypal example of intra‐tumour morphological heterogeneity. The mechanisms underlying coexistence of these different morphologic entities are poorly understood, although theories include that these components either represent ‘collision’ of independent tumours or evolve from a common ancestor. We performed comprehensive clinico‐pathological analysis of a cohort of 82 MDLs and found: i) MDLs more frequently co‐exist with ductal carcinoma in situ (DCIS) than lobular carcinoma in situ (LCIS); ii) the E‐cadhe...
Source: The Journal of Pathology - January 18, 2018 Category: Pathology Authors: Amy E McCart Reed, Jamie R Kutasovic, Katia Nones, Jodi M Saunus, Leonard Da Silva, Felicity Newell, Stephen Kazakoff, Lewis Melville, Janani Jayanthan, Ana Cristina Vargas, Lynne E Reid, Jonathan Beesley, Xiao Qing Chen, Anne Marie Patch, D David Clousto Tags: Original Paper Source Type: research
Recent Advances and Opportunities in Proteomic Analyses of Tumor Heterogeneity
Abstract
Solid tumor malignancies comprise a highly variable admixture of tumor and non‐tumor cellular populations, forming a complex cellular ecosystem and tumor microenvironment. This tumor heterogeneity is not incidental and is known to correlate with poor patient prognosis for many cancer types. Indeed, non‐malignant cell populations, such as vascular endothelial and immune cells, are known to play key roles supporting and, in some cases, driving aggressive tumor biology and represent targets of emerging therapeutics, such as anti‐angiogenesis and immune checkpoint inhibitors. The biochemical interplay between th...
Source: The Journal of Pathology - January 18, 2018 Category: Pathology Authors: Nicholas W. Bateman, Thomas P. Conrads Tags: Invited Review Source Type: research
Bridging the molecular divide: alcohol ‐induced downregulation of PAX9 and tumour development
The Journal of Pathology,Volume 244, Issue 4, Page 386-388, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 18, 2018 Category: Pathology Source Type: research
Mixed ductal ‐lobular carcinomas: evidence for progression from ductal to lobular morphology
The Journal of Pathology,Volume 244, Issue 4, Page 460-468, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 18, 2018 Category: Pathology Source Type: research
Bridging the molecular divide: Alcohol ‐induced downregulation of PAX9 and tumour development
Abstract
The pathogenesis of oro‐esophaeal squamous cell carcinoma is causally linked to the consumption of alcohol. Beyond the carcinogenic effects of ethanol and its metabolites via DNA damage, the precise mechanisms by which alcohol drives tumorigenesis remain to be fully elucidated. A novel contributor now revealed is aberrant differentiation and proliferation mediated by suppression of PAX9, a key regulator of normal squamous maturation in oro‐esophageal tissues. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 18, 2018 Category: Pathology Authors: Kenji Mark Fujihara, Nicholas James Clemons Tags: Invited Commentary Source Type: research
Established, emerging and elusive molecular targets in the treatment of lung cancer
The Journal of Pathology,Volume 244, Issue 5, Page 565-577, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Source Type: research
Clear cell carcinomas of the ovary and kidney: clarity through genomics
The Journal of Pathology,Volume 244, Issue 5, Page 550-564, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Source Type: research
Recent advances and opportunities in proteomic analyses of tumour heterogeneity
The Journal of Pathology,Volume 244, Issue 5, Page 628-637, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Source Type: research
The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses
The Journal of Pathology,Volume 244, Issue 5, Page 538-549, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Source Type: research
Clear cell carcinomas of the ovary and kidney: clarity through genomics
Abstract
Clear cell ovarian carcinoma (CCOC) and clear cell renal cell carcinoma (ccRCC) both feature clear cytoplasm due to the accumulation of cytoplasmic glycogen. Genomic studies have demonstrated several mutational similarities between these two diseases including frequent alterations in the chromatin remodeling SWI/SNF and cellular proliferation PI3K/mTOR pathways, as well as a shared hypoxia‐like mRNA expression signature. Although many targeted treatment options have been approved for advance stage ccRCC, CCOC patients are still treated with conventional platinum and taxane chemotherapy, to which they are resista...
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Authors: Jennifer X. Ji, Yi Kan Wang, Dawn R. Cochrane, David G. Huntsman Tags: Invited Review Source Type: research
Established, emerging, and elusive molecular targets in the treatment of lung cancer
Abstract
Although histological subtype still underlies tumor classification and treatment, the recognition that lung cancer is, largely, a genetic disease has prompted a push to reconfigure cancer taxonomies according to molecular criteria. In this review, we discuss established (e.g. EGFR, ALK, ROS1, PD‐1/PD‐L1), emerging (e.g. MET, RET, NTRK), and elusive (e.g. TP53, KRAS, MYC) molecular targets in the treatment of lung cancer. We synthesize a large and rapidly growing body of literature regarding the discovery and therapeutic inhibition of these targets in lung cancer. (Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Authors: Jean ‐Nicolas Gallant, Christine M. Lovly Tags: Invited Review Source Type: research
The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses
Abstract
Endometrial cancer is a clinically heterogeneous disease and it is becoming increasingly clear that this heterogeneity may be a function of the diversity of the underlying molecular alterations. Recent large scale genomic studies have revealed that endometrial cancer can be divided into at least four distinct molecular subtypes, with well described underlying genomic aberrations. These subtypes can be reliably delineated and carry significant prognostic as well as predictive information; embracing and incorporating them into clinical practice is thus attractive. The road towards the integration of molecular featur...
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Authors: Jessica McAlpine, Alicia Leon ‐Castillo, Tjalling Bosse Tags: Invited Review Source Type: research
Jeremy Jass Prize for Research Excellence in Pathology 2016
(Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Tags: Announcement Source Type: research
Issue Information
(Source: The Journal of Pathology)
Source: The Journal of Pathology - January 17, 2018 Category: Pathology Tags: Issue Information Source Type: research
