Multispectral imaging for quantitative and compartment ‐specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
The Journal of Pathology,Volume 244, Issue 4, Page 421-431, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 27, 2017 Category: Pathology Source Type: research
Targeting DNA repair: the genome as a potential biomarker
The Journal of Pathology,Volume 244, Issue 5, Page 586-597, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 27, 2017 Category: Pathology Source Type: research
---
The Journal of Pathology,Volume 244, Issue 3, Page 260-264, March 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 27, 2017 Category: Pathology Source Type: research
Revealing the Glioma Cancer Stem Cell Interactome, One Niche at a Time
Abstract
Glioblastoma cancer stem cells (CSCs) are insidious. They extensively infiltrate brain tissue, resist radio‐ and chemotherapy, and are thought to represent the ultimate drivers of disease progression. New research has identified CD109, a GPI‐anchored protein, on a population of perivascular CSCs. Interrogation of primary human tumor tissue suggests a role for CD109‐expressing CSCs in the progression from low‐ to high‐grade glioma, and animal modeling reveals a critical role for CD109 in the maintenance of the GBM CSC phenotype. Further, CD109‐expressing CSCs appear to drive the proliferation of adjacen...
Source: The Journal of Pathology - December 27, 2017 Category: Pathology Authors: Daniel J. Silver, Justin D. Lathia Tags: Invited Commentary Source Type: research
Targeting DNA repair: the genome as a potential biomarker
Abstract
Genomic instability and mutations are fundamental aspects of human malignancies, leading to progressive accumulation of the hallmarks of cancer. For some time, it has been clear that key mutations may be used both as prognostic and predictive biomarkers, the best‐known examples being the presence of germline BRCA1 or BRCA2 mutations, which are not only associated with improved prognosis in ovarian cancer, but are also predictive of response to poly(ADP‐ribose) polymerase (PARP) inhibitors. Although biomarkers as specific and powerful as these are rare in human malignancies, next generation sequencing and impro...
Source: The Journal of Pathology - December 27, 2017 Category: Pathology Authors: Ksenija Nesic, Matthew Wakefield, Olga Kondrashova, Clare L. Scott, Iain A. McNeish Tags: Invited Review Source Type: research
Multispectral imaging for quantitative and compartment ‐specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients
In conclusion, the fluorescence multiplexed IHC method, based on only one tissue section, provided a reliable quantification and localization of immune cells in cancer tissue. The application of this technique on clinical biopsies can provide a basic characterization of immune infiltrates to guide clinical decisions in the era of immunotherapy. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 27, 2017 Category: Pathology Authors: Artur Mezheyeuski, Christian Holst Bergsland, Max Backman, Dijana Djureinovic, Tobias Sj öblom, Jarle Bruun, Patrick Micke Tags: Original Paper Source Type: research
Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1 ‐related stroke
ABSTRACT
Mutations in the α1 (COL4A1) or α2 (COL4A2) chains of collagen type IV, a major component of the vascular basement membrane, cause intracerebral haemorrhages with variable expressivity and reduced penetrance by mechanisms that remain poorly understood. Here we sought to investigate the cellular mechanisms of COL4A1‐related intracerebral haemorrhage and identify a marker for haemorrhage risk‐stratification. A combination of histological, immunohistochemical and electron microscopy analyses were used to analyse the brain parenchyma, cerebrovasculature, and retinal vessels of mice expressing the disease‐causi...
Source: The Journal of Pathology - December 20, 2017 Category: Pathology Authors: Julien Ratelade, Nicolas Mezouar, Val érie Domenga‐Denier, Ambre Rochey, Emmanuelle Plaisier, Anne Joutel Tags: Original Paper Source Type: research
Severity of arterial defects in the retina correlates with the burden of intracerebral haemorrhage in COL4A1 ‐related stroke
The Journal of Pathology,Volume 244, Issue 4, Page 408-420, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 20, 2017 Category: Pathology Source Type: research
Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan ‐omics precision
The Journal of Pathology,Volume 244, Issue 5, Page 525-537, April 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 19, 2017 Category: Pathology Source Type: research
Human papillomavirus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness
Abstract
Accumulating evidence indicates that the human papillomavirus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Subpopulations of cells that reside within tumours are responsible for tumour resistance to cancer therapy and recurrence. However, the identity of such cells residing in cervical cancer and their relationship with the HPV‐E6 protein have not been identified. Here, we isolated sphere‐forming cells, which showed self‐renewal ability, from primary cervical tumours. Gene expression profiling revealed that cluster of differentiation (CD) 55 was upregulated in primary cervical...
Source: The Journal of Pathology - December 19, 2017 Category: Pathology Authors: Thomas Ho ‐Yin Leung, Hermit Wai‐Man Tang, Michelle Kwan‐Yee Siu, David Wai Chan, Karen Kar‐Loen Chan, Annie Nga‐Yin Cheung, Hextan Yuen‐Sheung Ngan Tags: Original Paper Source Type: research
Genomic classifications of renal cell carcinoma: a critical step towards the future application of personalized kidney cancer care with pan ‐omics precision
Abstract
Over the past twenty years, classifications of kidney cancer have undergone major revisions based on morphological refinements and molecular characterizations. The 2016 WHO classification of renal tumors recognizes more than 10 different renal cell carcinoma (RCC) subtypes. Furthermore, the marked inter‐ and intra‐tumor heterogeneity of RCC is now well‐appreciated. Nevertheless, contemporary multi‐omics studies of RCC, encompassing genomics, transcriptomics, proteomics, and metabolomics, not only highlight apparent diversity but also showcase and underline commonality. Here, we wish to provide an integrate...
Source: The Journal of Pathology - December 19, 2017 Category: Pathology Authors: James J. Hsieh, Valerie Le, Dengfeng Cao, Emily H. Cheng, Chad J. Creighton Tags: Invited Review Source Type: research
Human papilloma virus E6 protein enriches the CD55(+) population in cervical cancer cells, promoting radioresistance and cancer aggressiveness
Abstract
Accumulating evidence indicates that the human papilloma virus (HPV) E6 protein plays a crucial role in the development of cervical cancer. Subpopulations of cells that reside within tumours are responsible for tumour resistance to cancer therapy and recurrence. However, the identity of such cells residing in cervical cancer and their relationship with the HPV‐E6 protein have not been identified. Here, we isolated sphere‐forming cells, which showed self‐renewal ability, from primary cervical tumours. Gene expression profiling revealed that cluster of differentiation (CD) 55 was upregulated in primary cervica...
Source: The Journal of Pathology - December 19, 2017 Category: Pathology Authors: Thomas Ho ‐Yin Leung, Hermit Wai‐Man Tang, Michelle Kwan‐Yee Siu, David Wai Chan, Karen Kar‐Loen Chan, Annie Nga‐Yin Cheung, Hextan Yuen‐Sheung Ngan Tags: Original Paper Source Type: research
Nrf2 promotes oesophageal cancer cell proliferation via metabolic reprogramming and detoxification of reactive oxygen species
ABSTRACT
Cancer cells consume a large amount of energy and maintain high levels of anabolism to promote cell proliferation via metabolic reprogramming. Nuclear factor erythroid 2‐related factor 2 (Nrf2; NFE2L2) is a master transcription regulator of stress responses and promotes metabolic reprogramming to support cell proliferation in various types of cancer. As oesophageal cancer is one of the most aggressive gastrointestinal cancers, we aimed to clarify the effect of Nrf2 on metabolic reprogramming in oesophageal cancer. The relationship between Nrf2 expression and clinical outcome was evaluated using a database compri...
Source: The Journal of Pathology - December 15, 2017 Category: Pathology Authors: Yuki Kitano, Yoshifumi Baba, Shigeki Nakagawa, Keisuke Miyake, Masaaki Iwatsuki, Takatsugu Ishimoto, Yo ‐ichi Yamashita, Naoya Yoshida, Masayuki Watanabe, Mitsuyoshi Nakao, Hideo Baba Tags: Original Paper Source Type: research
---
The Journal of Pathology,Volume 244, Issue 3, Page 346-357, March 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 15, 2017 Category: Pathology Source Type: research
---
The Journal of Pathology,Volume 244, Issue 3, Page 334-345, March 2018. (Source: The Journal of Pathology)
Source: The Journal of Pathology - December 15, 2017 Category: Pathology Source Type: research
