Rod metabolic demand drives progression in retinopathies
Publication date: Available online 25 August 2015 Source:Taiwan Journal of Ophthalmology Author(s): Michael K. Lin, Soo Hyun Kim, Lijuan Zhang, Yi-Ting Tsai, Stephen H. Tsang Various factors are thought to cause the development and progression of disease in macular degeneration, diabetic retinopathy, and retinitis pigmentosa. Some of the deleterious processes include oxidative stress, hypoxia, metabolic derangement, genetics, and vasculopathy. In this review, we present a unified theory for the pathophysiology of several retinopathies based on the unique and intense metabolism of rod photoreceptors. (Source: ...
Source: Taiwan Journal of Ophthalmology - August 26, 2015 Category: Opthalmology Source Type: research
Latest advances in the treatment of corneal diseases
Publication date: Available online 25 August 2015 Source:Taiwan Journal of Ophthalmology Author(s): I-Jong Wang (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - August 26, 2015 Category: Opthalmology Source Type: research
Changes of intraocular pressure and refractive status in children following cycloplegic refraction with 1% cyclopentolate and 1% tropicamide
Conclusion Cycloplegic mydriasis with 1% cyclopentolate and 1% tropicamide caused IOP changes in preschool and school-aged children with hyperopia. Ophthalmologists should be very cautious in monitoring IOP changes for children with cycloplegic medication use. (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - August 25, 2015 Category: Opthalmology Source Type: research
Deep vein thrombosis due to continuous prone positioning after retinal detachment surgery
Publication date: Available online 6 August 2015 Source:Taiwan Journal of Ophthalmology Author(s): Chih-Ping Wang, Evelyn Jou-Chen Huang, Chien-Neng Kuo, Chien-Hsiung Lai In March 2014, a 56-year-old woman without previous underlying disease underwent encircling scleral buckling, 20-gauge pars plana vitrectomy, cryotherapy around a retinal tear, and gas-fluid exchange with 15% perfluoropropane flush for upper rhegmatogenous retinal detachment of the left eye. However, she developed progressive left leg swelling, pain, warmth, and redness, associated with difficulty in elevating her left leg after continuously m...
Source: Taiwan Journal of Ophthalmology - August 7, 2015 Category: Opthalmology Source Type: research
Autologous serum therapy in recalcitrant laser-assisted in situ keratomileusis-induced neurotrophic epitheliopathy
Conclusion Risk factors of recalcitrant LINE in femtosecond laser-assisted myopic LASIK were identified as older age, a thinner flap (<110 μm), and a small flap diameter (<8.5 mm). Autologous serum eye drops can effectively improve corneal surface conditions and postoperative visual acuity. (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - July 24, 2015 Category: Opthalmology Source Type: research
Rescue effects of intravitreal aflibercept in the treatment of neovascular age-related macular degeneration
We reported the rescue results of intravitreal aflibercept in patients with treatment-resistant neovascular age-related macular degeneration (AMD). We retrospectively analyzed eyes with neovascular AMD resistant to posterior subtenon triamcinolone, intravitreal ranibizumab, and/or bevacizumab treatment in a tertiary medical center in middle Taiwan between December 2013 and October 2014. We then switched treatment to 2.0 mg aflibercept. The main outcome included changes in best-corrected visual acuity and central foveal thickness measured by optical coherence tomography during monthly follow-up. There were 204 patients wit...
Source: Taiwan Journal of Ophthalmology - July 17, 2015 Category: Opthalmology Source Type: research
Retinal complications associated with congenital optic disc anomalies determined by swept source optical coherence tomography
Publication date: Available online 15 July 2015 Source:Taiwan Journal of Ophthalmology Author(s): Makoto Inoue Optical coherence tomography has evolved over the past 2 decades to be an important ancillary method to evaluate diseases of the anterior and posterior segments of the eye. The more recent development of swept-source optical coherence tomography (SS-OCT) with a wavelength-tunable laser centered at 1050 nm and deeper imaging depth of 2.6 mm has enabled clinicians to evaluate congenital optic disc anomalies including optic disc pits, optic disc colobomas, and morning glory syndrome in more detail. The SS-OCT...
Source: Taiwan Journal of Ophthalmology - July 17, 2015 Category: Opthalmology Source Type: research
Detecting optic nerve head deformation and retinal nerve fiber layer thinning in glaucoma progression
Publication date: Available online 15 June 2015 Source:Taiwan Journal of Ophthalmology Author(s): Christopher K.S. Leung The application of digital imaging technologies including confocal scanning laser ophthalmoscopy (CSLO), optical coherence tomography (OCT), and scanning laser polarimetry (SLP) has significantly improved the detection of optic nerve head (ONH) deformation and progressive retinal nerve fiber layer (RNFL) thinning for assessment of glaucoma progression. Algorithms for change analysis such as topographic change analysis and guided progression analysis perform event analysis of serial ONH surface heigh...
Source: Taiwan Journal of Ophthalmology - June 15, 2015 Category: Opthalmology Source Type: research
Comparison of trabeculectomy with Ex-PRESS shunt implantation in primary-open-angle-glaucoma patients: A retrospective study
Discussion TRBC and Ex-PRESS implantation provided similar IOP control and reduction of postoperative medication with low incidence of postoperative complications at intermediate-term follow up. However, the Ex-PRESS implantation device may last longer but with extra costs. It is up to the surgeon to decide which procedure to use according to the patient's situation and economic circumstances. (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - June 13, 2015 Category: Opthalmology Source Type: research
Glaucomatocyclitic crisis and glaucomatous optic neuropathy
Publication date: Available online 10 June 2015 Source:Taiwan Journal of Ophthalmology Author(s): Kwou-Yeung Wu (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - June 11, 2015 Category: Opthalmology Source Type: research
Complex genetics of familial exudative vitreoretinopathy and related pediatric retinal detachments
Publication date: Available online 6 June 2015 Source:Taiwan Journal of Ophthalmology Author(s): Hiroyuki Kondo Familial exudative vitreoretinopathy (FEVR) is a hereditary vitreoretinal disorder that can cause various types of retinal detachments. The abnormalities in eyes with FEVR are caused by poor vascularization in the peripheral retina. The genetics of FEVR is highly heterogeneous, and mutations in the genes for Wnt signaling and a transcription factor have been reported to be responsible for FEVR. These factors have been shown to be the regulators of the pathophysiological pathways of retinal vascular developme...
Source: Taiwan Journal of Ophthalmology - June 6, 2015 Category: Opthalmology Source Type: research
Occult Descemet's membrane detachment after phacoemulsification surgery mimicking pseudophakic bullous keratopathy
Publication date: Available online 6 June 2015 Source:Taiwan Journal of Ophthalmology Author(s): Shih-Wen Wang , Sung-Huei Tseng We herein report two cases of occult Descemet's membrane detachment (DMD) after phacoemulsification surgery, which initially presented as persistent corneal edema and had been considered as pseudophakic bullous keratopathy. The patients were thus scheduled to receive corneal transplantation. For Case 1, DMD was incidentally detected by slit-lamp examination 2 months postoperatively, only when part of the cornea became clearer. For Case 2, anterior segment optical coherence tomography demons...
Source: Taiwan Journal of Ophthalmology - June 6, 2015 Category: Opthalmology Source Type: research
Distribution of corneal and ocular spherical aberrations in eyes with cataract in the Taiwanese population
Conclusion Corneal and ocular SAs varied among cataract patients and correlated with AL. After 50 years of age, ocular SAs increased significantly because of an increase in internal (lenticular) SAs. Corneal SAs in Taiwanese patients were larger than those in Japanese patients and similar to those in Chinese and Malaysian populations. Preoperative measurement of wavefront aberrations is necessary to select which aspherical intraocular lenses are most suitable for achieving better postoperative visual quality. (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - May 13, 2015 Category: Opthalmology Source Type: research
Development of macular holes in diabetic retinopathy with fibrovascular proliferation: Report of four cases
We report four cases of MHs in diabetic retinopathy with fibrovascular proliferation; formation of MHs were studied using sequential pre-MH optical coherence tomography (OCT). In Case 1, initial OCT revealed tractional schisis and cysts with fovea detachment. An MH with bowl-shaped detachment was noted within 6 weeks. In Case 2, initial OCT revealed thickened posterior hyaloid membrane with vitreomacular traction. Five and a half years later, OCT showed MH formation with possible vitreomacular separation. Some epiretinal membrane was also noted in the macula area. In Case 3, initial OCT revealed tractional retinal elevatio...
Source: Taiwan Journal of Ophthalmology - May 13, 2015 Category: Opthalmology Source Type: research
Immunosuppressive therapy for eye diseases: Effectiveness, safety, side effects and their prevention
In this report, we summarize the effectiveness and safety of immunosuppressive drug therapy utilized in the treatment of ocular inflammatory diseases. (Source: Taiwan Journal of Ophthalmology)
Source: Taiwan Journal of Ophthalmology - May 13, 2015 Category: Opthalmology Source Type: research
