Vitamin D receptor genetic polymorphisms and the risk of multiple sclerosis: A systematic review and meta-analysis
Publication date: Available online 22 February 2020Source: SteroidsAuthor(s): Asadollah Mohammadi, Asaad Azarnezhad, Hashem Khanbabaei, Esmael Izadpanah, Rasoul Abdollahzadeh, George E. Barreto, Amirhossein SahebkarAbstractThere are conflicting results regarding the exact effect of the vitamin D receptor (VDR) gene polymorphisms on the susceptibility to multiple sclerosis (MS). Therefore, we aimed to investigate the impact of four major studied VDR gene polymorphisms consisting of ApaI, BsmI, FokI, and TaqI on the risk of MS in the Iranian population. A literature search was performed in various databases to find case-cont...
Source: Steroids - February 22, 2020 Category: Drugs & Pharmacology Source Type: research
Biological Activity and Apoptotic Signaling Pathway of C11- Functionalized Cephalostatin 1 Analogues
Publication date: Available online 22 February 2020Source: SteroidsAuthor(s): Mansour M. Nawasreh, Elham I. Alzyoud, Zainab A. Al-Mazaydeh, Majdoleen S. Rammaha, Salim R. Yasin, Lubna H. TahtamouniAbstractCephalostatin 1, a potent anti-cancer agent, is a natural bis-steroidal alkaloid that causes cell death in the subnanomolar to picomolar ranges via an atypical apoptosis pathway. Although cephalostatin 1 is a highly effective anticancer drug, its availability limits its utilization. We previously reported the synthesis of two 12'α-hydroxy derivatives of cephalostatin 1 that induce cell death by activating the ER stress a...
Source: Steroids - February 22, 2020 Category: Drugs & Pharmacology Source Type: research
Sinulasterols A–C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa
Publication date: May 2020Source: Steroids, Volume 157Author(s): Min Yang, Wan-Xiang Cui, Heng Li, Song-Wei Li, Li-Gong Yao, Wei Tang, I. Wayan Mudianta, Yue-Wei GuoAbstractThree new oxygenated steroids, sinulasterols A–C (1–3), along with seven known related steroids 4–10, were isolated from the Chinese soft coral Sinularia depressa. The structures of the new compounds were established from extensive spectroscopic data analyses and by comparison of their spectral data with those reported in the literature. Among the new compounds, metabolites 1 and 2 featured on unusual C-18 oxygenated pattern. In the TNF-α bioassa...
Source: Steroids - February 22, 2020 Category: Drugs & Pharmacology Source Type: research
Efficient synthesis of cholic acid derivates through stereoselective C–H functionalization from hyodeoxycholic acid
Publication date: May 2020Source: Steroids, Volume 157Author(s): Yu-Yan Liang, Huan Huang, Yang Li, Rong-Kai Du, Jing Li, Yong-Hong Liu, Shan Li, Lei ZhangAbstractFive cholic acid derivatives (including allo-ω-muricholic acid and CDCA) were synthesized from hyodeoxycholic acid via selective oxidation of C3- or C6-hydroxyl groups by IBX and NBS oxidants and stereocontrolled conversion. The hydroxyl group could be introduced through hydrolyzing α-Br keto with K2CO3 aqueous solution or through oxidizing the double bond by monoperoxyphthalic acid. The reduction of C6-O6 carbonyl to methylene could undergo with PTSH, NaBH3CN ...
Source: Steroids - February 21, 2020 Category: Drugs & Pharmacology Source Type: research
The Synthesis of 4-Chloro-17β-(hydroxymethyl)-17α-methyl-18-norandrosta-4,13-diene-3α-ol – proposed long term metabolite (M4) of oralturinabol
Publication date: Available online 19 February 2020Source: SteroidsAuthor(s): D. Yu. Shostko, A.I. Liubina, Yu.Yu. Kozyrkov, S.A. BeliaevAbstract4-Chloro-17β-(hydroxymethyl)-17α-methyl-18-norandrosta-4,13-diene-3α-ol is one of proposed long term metabolites of oralturinabol (anabolic androgenic steroid restricted in sport). The synthesis of 4-chloro-17β-(hydroxymethyl)-17α-methyl-18-norandrosta-4,13-diene-3α-ol was achieved. Isomerisation of configuration of 13-carbon was used for construction of 17β-(hydroxymethyl)-17α-methyl fragment. The proposed route of synthesis allows to obtain 3β-hydroxy isomer as well . (Source: Steroids)
Source: Steroids - February 19, 2020 Category: Drugs & Pharmacology Source Type: research
Synthesis, complete NMR assignment and structural study of a steroidal dimer of 17α-ethynyl-5α,10α-estran-17β-ol with diethynylbenzene spacer
Publication date: Available online 19 February 2020Source: SteroidsAuthor(s): Nancy Aguilar-Valdez, Nuria Esturau-Escofet, Oscar González-Antonio, Margarita Romero-Ávila, Blas Flores-Pérez, Marco A. Leyva, David Díaz, Rosa Santillan, Norberto FarfánAbstractA phenylene-bridged steroidal dimer derived from 17α-ethynyl-5α,10α-estran-17β-ol with molecular rotor-like architecture was synthesized to investigate the supramolecular interactions directing the crystallization of these systems. Structures with varying importance in complementarity between H-bonding and hydrophobic interactions can be observed directing the p...
Source: Steroids - February 19, 2020 Category: Drugs & Pharmacology Source Type: research
Screening and identification of salivary biomarkers for assessing the effects of exogenous testosterone administration on HPG and HPA axes and ECS
This study aimed to systematically screen and identify sensitive biomarkers from 21 candidates including both the contents of nine steroids and one endocannabinoid and their ratios in saliva. Three screening criteria were whether there were intergroup differences, time-dependent changes and considerable relative stability during a 4-h period after exogenous testosterone administration. This study used LC-APCI+-MS/MS to determine the salivary levels of the biomarkers on 62 male healthy undergraduates who were divided into testosterone administration and placebo control groups. The results revealed that salivary testosterone...
Source: Steroids - February 19, 2020 Category: Drugs & Pharmacology Source Type: research
Analysis of steryl glucosides in rice bran-based fermented food by LC/ESI-MS/MS
In this study, three major SGs, i.e., glucosides of β-sitosterol, stigmasterol, and campesterol, were synthesized and used as standards for measurement of their contents in rice bran (RB)-based fermented food (FBRA) utilizing Aspergillus oryzae and raw material (RM). The compounds were quantified using liquid chromatography/electrospray ionization-tandem mass spectrometry. It was found that β-sitosteryl glucoside was most abundant among the analyzed glucosides in both samples, and the contents of each SG in FBRA decreased about 35% from those of RM. In contrast to SGs, the contents of ASGs in FBRA increased 1.5-fold duri...
Source: Steroids - February 19, 2020 Category: Drugs & Pharmacology Source Type: research
Megestrol Acetate Induced Proliferation and Differentiation of Osteoblastic MC3T3-E1 Cells: A Drug Repurposing Approach
Publication date: Available online 19 February 2020Source: SteroidsAuthor(s): Serene A. Badran, Atia-tul-Wahab, Sharmeen Fayyaz, Bushra Taj, M. Iqbal ChoudharyAbstractAimsDrug repurposing or repositioning i.e; identifying new indications for existing drugs have recently accelerate the process of drug development and discovery. Megestrol acetate (1) is a well-known progestin. It is commonly used as an appetite stimulant, and also in the treatment of breast, and endometrial cancer. The aim of this study is to investigate the effect of megestrol acetate (1) in osteoblast differentiation, and to determine the possible mechanis...
Source: Steroids - February 19, 2020 Category: Drugs & Pharmacology Source Type: research
Detection and quantitation of ecdysterone in human serum by liquid chromatography coupled to tandem mass spectrometry
Publication date: Available online 14 February 2020Source: SteroidsAuthor(s): Gabriella Ambrosio, Jan Felix Joseph, Bernhard Wuest, Monica Mazzarino, Xavier de la Torre, Patrick Diel, Francesco Botrè, Maria Kristina ParrAbstractThe polyhydroxylated phytosteroid ecdysterone is present in various plants (e.g. spinach). It is widely marketed as the active component of dietary supplements, due to its reported health and performance promoting effects. For evaluation of its actual bioavailability, a fast and sensitive method was developed, optimized and validated for human serum. Instrumental analysis was performed utilizing li...
Source: Steroids - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
New A-homo lactam D-homo lactone androstane derivative: synthesis and evaluation of cytotoxic and anti-inflammatory activities in vitro
Publication date: Available online 14 February 2020Source: SteroidsAuthor(s): Marina P. Savić, Dušan Dj. Škorić, Ivana Z. Kuzminac, Dimitar S. Jakimov, Vesna V. Kojić, Lucie Rárová, Miroslav Strnad, Evgenija A. DjurendićAbstractThis paper describes the synthesis of a new A-homo lactam D-homo lactone androstane derivative from dehydroepiandrosterone. To evaluate the impact of the introduction of nitrogen in the parental scaffold on biological activity, a new androstane enamide-type lactam derivative was prepared and characterized. The new compound as well as starting compounds were screened for cytotoxic, anti-angio...
Source: Steroids - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
Synthesis of ursodeoxycholic acid from plant-source (20S)-21-hydroxy-20-methylpregn-4-en-3-one
Publication date: Available online 14 February 2020Source: SteroidsAuthor(s): Jie Wang, Xiang-Zhong Gu, Li-Ming He, Chen-Chen Li, Wen-Wei QiuAbstractA novel synthetic route of producing ursodeoxycholic acid (UDCA) was developed through multiple reactions from cheap and commercially available bisnoralcohol (BA). The key reaction conditions, including solvents, bases and reaction temperatures of the route were investigated and optimized. In the straightforward route for preparation of UDCA, most of the reaction steps have high conversions with average yields of 91%, and overall yield up to 59% (6 steps) from the plant-source...
Source: Steroids - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
Cucurbitacin IIb, a steroidal triterpene from Ibervillea sonorae induces antiproliferative and apoptotic effects on cervical and lung cancer cells
The objective of the present work was to isolate and chemically characterize the active compounds of the methanolic extract of the roots of I. sonorae and to evaluate their antiproliferative activity and induction of apoptosis. By chromatographic column separation and using NMR spectroscopy experiments, cucurbitacin IIb (CIIb), known as 23,24-dihydrocucurbitacin F or hemslecin B, was isolated and identified for the first time as a chemical constituent of the crude methanolic extract of this plant. The antiproliferative activity of CIIb was evaluated by MTT assay, and the apoptosis induction capacity was monitored by annexi...
Source: Steroids - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
Sinulasterols A−C, three new bioactive oxygenated steroids from the South China Sea soft coral Sinularia depressa
Publication date: Available online 15 February 2020Source: SteroidsAuthor(s): Min Yang, Wan-Xiang Cui, Heng Li, Song-Wei Li, Li-Gong Yao, Wei Tang, I. Wayan Mudianta, Yue-Wei GuoAbstractThree new oxygenated steroids, sinulasterols A−C (1−3), along with seven known related steroids 4−10, were isolated from the Chinese soft coral Sinularia depressa. The structures of the new compounds were established from extensive spectroscopic data analyses and by comparison of their spectral data with those reported in the literature. Among the new compounds, metabolites 1 and 2 featured on unusual C-18 oxygenated pattern. In the T...
Source: Steroids - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
Efficient synthesis of cholic acid derivates through stereoselective C-H functionalization from hyodeoxycholic acid
Publication date: Available online 15 February 2020Source: SteroidsAuthor(s): Yu-Yan Liang, Huan Huang, Yang Li, Rong-Kai Du, Jing Li, Yong-Hong Liu, Shan Li, Lei ZhangAbstractFive cholic acid derivatives (including allo-ω-muricholic acid and CDCA) were synthesized from hyodeoxycholic acid via selective oxidation of C3- or C6-hydroxyl groups by IBX and NBS oxidants and stereocontrolled conversion. The hydroxyl group could be introduced through hydrolyzing α-Br keto with K2CO3 aqueous solution or through oxidizing the double bond by monoperoxyphthalic acid. The reduction of C6-O6 carbonyl to methylene could undergo with P...
Source: Steroids - February 16, 2020 Category: Drugs & Pharmacology Source Type: research
